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DUOX1 (dual oxidase 1)

Identity

Alias (NCBI)LNOX1
NOXEF1
THOX1
HGNC (Hugo) DUOX1
HGNC Alias symbNOXEF1
THOX1
LNOX1
HGNC Alias nameNADPH thyroid oxidase 1
 flavoprotein NADPH oxidase
 nicotinamide adenine dinucleotide phosphate oxidase
LocusID (NCBI) 53905
Atlas_Id 47651
Location 15q21.1  [Link to chromosome band 15q21]
Location_base_pair Starts at 45129994 and ends at 45165574 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)DUOX1   3062
Cards
Entrez_Gene (NCBI)DUOX1    dual oxidase 1
AliasesLNOX1; NOXEF1; THOX1
GeneCards (Weizmann)DUOX1
Ensembl hg19 (Hinxton)ENSG00000137857 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137857 [Gene_View]  ENSG00000137857 [Sequence]  chr15:45129994-45165574 [Contig_View]  DUOX1 [Vega]
ICGC DataPortalENSG00000137857
TCGA cBioPortalDUOX1
AceView (NCBI)DUOX1
Genatlas (Paris)DUOX1
SOURCE (Princeton)DUOX1
Genetics Home Reference (NIH)DUOX1
Genomic and cartography
GoldenPath hg38 (UCSC)DUOX1  -     chr15:45129994-45165574 +  15q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUOX1  -     15q21.1   [Description]    (hg19-Feb_2009)
GoldenPathDUOX1 - 15q21.1 [CytoView hg19]  DUOX1 - 15q21.1 [CytoView hg38]
ImmunoBaseENSG00000137857
genome Data Viewer NCBIDUOX1 [Mapview hg19]  
OMIM606758   
Gene and transcription
Genbank (Entrez)AF213465 AF230495 AK075268 AK128591 AK172859
RefSeq transcript (Entrez)NM_017434 NM_175940
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUOX1
Alternative Splicing GalleryENSG00000137857
Gene ExpressionDUOX1 [ NCBI-GEO ]   DUOX1 [ EBI - ARRAY_EXPRESS ]   DUOX1 [ SEEK ]   DUOX1 [ MEM ]
Gene Expression Viewer (FireBrowse)DUOX1 [ Firebrowse - Broad ]
GenevisibleExpression of DUOX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53905
GTEX Portal (Tissue expression)DUOX1
Human Protein AtlasENSG00000137857-DUOX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRD9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRD9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRD9
Splice isoforms : SwissVarQ9NRD9
Catalytic activity : Enzyme1.11.1.- [ Enzyme-Expasy ]   1.11.1.-1.11.1.- [ IntEnz-EBI ]   1.11.1.- [ BRENDA ]   1.11.1.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NRD9
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    FAD_FR (PS51384)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (EBI)DUOX1/Duox    DUOX_peroxidase    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    FAD-bd_8    FAD-bd_FR_type    Fe3_Rdtase_TM_dom    Fe_red_NAD-bd_6    FNR_nucleotide-bd    Haem_peroxidase_animal    Haem_peroxidase_sf    Haem_peroxidase_sf_animal    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)    EF-hand_1 (PF00036)    FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam03098    pfam00036    pfam08022    pfam01794    pfam08030   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)DUOX1
Blocks (Seattle)DUOX1
SuperfamilyQ9NRD9
Human Protein Atlas [tissue]ENSG00000137857-DUOX1 [tissue]
Peptide AtlasQ9NRD9
HPRD08421
IPIIPI00185038   IPI00719817   IPI00647316   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRD9
IntAct (EBI)Q9NRD9
BioGRIDDUOX1
STRING (EMBL)DUOX1
ZODIACDUOX1
Ontologies - Pathways
QuickGOQ9NRD9
Ontology : AmiGOperoxidase activity  calcium ion binding  protein binding  endoplasmic reticulum  plasma membrane  plasma membrane  plasma membrane  thyroid hormone generation  thyroid hormone generation  defense response  response to oxidative stress  cell surface  NAD(P)H oxidase H2O2-forming activity  superoxide-generating NAD(P)H oxidase activity  apical plasma membrane  cytokine-mediated signaling pathway  heme binding  cell leading edge  cuticle development  hormone biosynthetic process  superoxide anion generation  superoxide anion generation  hydrogen peroxide catabolic process  NADPH oxidase complex  NADP binding  hydrogen peroxide biosynthetic process  hydrogen peroxide biosynthetic process  response to cAMP  response to cAMP  positive regulation of wound healing  cellular oxidant detoxification  positive regulation of cell motility  
Ontology : EGO-EBIperoxidase activity  calcium ion binding  protein binding  endoplasmic reticulum  plasma membrane  plasma membrane  plasma membrane  thyroid hormone generation  thyroid hormone generation  defense response  response to oxidative stress  cell surface  NAD(P)H oxidase H2O2-forming activity  superoxide-generating NAD(P)H oxidase activity  apical plasma membrane  cytokine-mediated signaling pathway  heme binding  cell leading edge  cuticle development  hormone biosynthetic process  superoxide anion generation  superoxide anion generation  hydrogen peroxide catabolic process  NADPH oxidase complex  NADP binding  hydrogen peroxide biosynthetic process  hydrogen peroxide biosynthetic process  response to cAMP  response to cAMP  positive regulation of wound healing  cellular oxidant detoxification  positive regulation of cell motility  
NDEx NetworkDUOX1
Atlas of Cancer Signalling NetworkDUOX1
Wikipedia pathwaysDUOX1
Orthology - Evolution
OrthoDB53905
GeneTree (enSembl)ENSG00000137857
Phylogenetic Trees/Animal Genes : TreeFamDUOX1
HOGENOMQ9NRD9
Homologs : HomoloGeneDUOX1
Homology/Alignments : Family Browser (UCSC)DUOX1
Gene fusions - Rearrangements
Fusion : QuiverDUOX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUOX1 [hg38]
dbVarDUOX1
ClinVarDUOX1
MonarchDUOX1
1000_GenomesDUOX1 
Exome Variant ServerDUOX1
GNOMAD BrowserENSG00000137857
Varsome BrowserDUOX1
Genomic Variants (DGV)DUOX1 [DGVbeta]
DECIPHERDUOX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUOX1 
Mutations
ICGC Data PortalDUOX1 
TCGA Data PortalDUOX1 
Broad Tumor PortalDUOX1
OASIS PortalDUOX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUOX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDUOX1
Mutations and Diseases : HGMDDUOX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUOX1
DgiDB (Drug Gene Interaction Database)DUOX1
DoCM (Curated mutations)DUOX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUOX1 (select a term)
intoGenDUOX1
Cancer3DDUOX1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606758   
Orphanet
DisGeNETDUOX1
MedgenDUOX1
Genetic Testing Registry DUOX1
NextProtQ9NRD9 [Medical]
GENETestsDUOX1
Target ValidationDUOX1
Huge Navigator DUOX1 [HugePedia]
ClinGenDUOX1
Clinical trials, drugs, therapy
MyCancerGenomeDUOX1
Protein Interactions : CTD
Pharm GKB GenePA27516
PharosQ9NRD9
Clinical trialDUOX1
Miscellaneous
canSAR (ICR)DUOX1 (select the gene name)
HarmonizomeDUOX1
DataMed IndexDUOX1
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDUOX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:19:11 CET 2021

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