DUOX1 (dual oxidase 1)

Identity

Other names	LNOX1
	MGC138840
	MGC138841
	NOXEF1
	THOX1
HGNC	DUOX1
Location	15q21
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

External links

	Nomenclature
HGNC	DUOX1   3062
Entrez_Gene	DUOX1  53905  dual oxidase 1
	Cards
GeneCards	DUOX1
Ensembl	DUOX1 [Search_View]   ENSG00000137857 [Gene_View]
Genatlas	DUOX1
GeneLynx	DUOX1
eGenome	DUOX1
euGene	53905
	Genomic and cartography
GoldenPath	DUOX1  -  15q21   chr15:43209484-43245066 +  15q21.1   [Description]    (hg18-March_2006)
Ensembl	DUOX1 - 15q21.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	DUOX1
	Gene and transcription
Genbank	AF213465 [ ENTREZ ]
Genbank	AF230495 [ ENTREZ ]
Genbank	AK075268 [ ENTREZ ]
Genbank	AK128591 [ ENTREZ ]
Genbank	AK172859 [ ENTREZ ]
RefSeq	NM_017434 [ SRS ]    NM_017434 [ ENTREZ ]
RefSeq	NM_175940 [ SRS ]    NM_175940 [ ENTREZ ]
RefSeq	AC_000058 [ SRS ]    AC_000058 [ ENTREZ ]
RefSeq	AC_000147 [ SRS ]    AC_000147 [ ENTREZ ]
RefSeq	NC_000015 [ SRS ]    NC_000015 [ ENTREZ ]
RefSeq	NT_010194 [ SRS ]    NT_010194 [ ENTREZ ]
RefSeq	NW_001838218 [ SRS ]    NW_001838218 [ ENTREZ ]
RefSeq	NW_925884 [ SRS ]    NW_925884 [ ENTREZ ]
AceView	DUOX1 AceView - NCBI
Unigene	Hs.272813 [ SRS ]    Hs.272813 [ NCBI ]     HS272813 [ spliceNest ]
Fast-db	4516 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q14C85 [ SRS]    Q14C85 [ EXPASY ]     Q14C85 [ INTERPRO ]     Q14C85 [ UNIPROT ]
Prosite	PS00018 EF_HAND_1 [ SRS ]    PS00018 EF_HAND_1 [ Expasy ]
Prosite	PS50222 EF_HAND_2 [ SRS ]    PS50222 EF_HAND_2 [ Expasy ]
Prosite	PS50292 PEROXIDASE_3 [ SRS ]    PS50292 PEROXIDASE_3 [ Expasy ]
Interpro	IPR011992 EF-Hand_type [ SRS ]    IPR011992 EF-Hand_type [ EBI ]
Interpro	IPR002048 EF_hand_Ca_bd [ SRS ]    IPR002048 EF_hand_Ca_bd [ EBI ]
Interpro	IPR013112 FAD_bd_8 [ SRS ]    IPR013112 FAD_bd_8 [ EBI ]
Interpro	IPR013130 Fe3_reduct_TM_N [ SRS ]    IPR013130 Fe3_reduct_TM_N [ EBI ]
Interpro	IPR013121 Fe_red_NAD_bd_6 [ SRS ]    IPR013121 Fe_red_NAD_bd_6 [ EBI ]
Interpro	IPR002007 Haem_peroxidase_animal [ SRS ]    IPR002007 Haem_peroxidase_animal [ EBI ]
Interpro	IPR001125 Recoverin [ SRS ]    IPR001125 Recoverin [ EBI ]
CluSTr	Q14C85
Pfam	PF03098 An_peroxidase [ SRS ]    PF03098 An_peroxidase [ Sanger ]    pfam03098 [ NCBI-CDD ]
Pfam	PF00036 efhand [ SRS ]    PF00036 efhand [ Sanger ]    pfam00036 [ NCBI-CDD ]
Pfam	PF08022 FAD_binding_8 [ SRS ]    PF08022 FAD_binding_8 [ Sanger ]    pfam08022 [ NCBI-CDD ]
Pfam	PF01794 Ferric_reduct [ SRS ]    PF01794 Ferric_reduct [ Sanger ]    pfam01794 [ NCBI-CDD ]
Pfam	PF08030 NAD_binding_6 [ SRS ]    PF08030 NAD_binding_6 [ Sanger ]    pfam08030 [ NCBI-CDD ]
Smart	SM00054 EFh [EMBL]
Prodom	PD000012 EF-hand[INRA-Toulouse]
Prodom	Q14C85 Q14C85_HUMAN [ Domain structure ]   Q14C85 Q14C85_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q14C85
HPRD	08421
	Protein Interaction databases
DIP	Q14C85
IntAct	Q14C85
	Polymorphism : SNP, mutations, diseases
OMIM	606758    [ map ]
GENECLINICS	606758
SNP	DUOX1 [dbSNP-NCBI]
SNP	NM_017434 [SNP-NCI]
SNP	NM_175940 [SNP-NCI]
SNP	DUOX1 [GeneSNPs - Utah]  DUOX1] [HGBASE - SRS]
HAPMAP	DUOX1 [HAPMAP]
HGMD	DUOX1
	General knowledge
Family Browser	DUOX1 [UCSC Family Browser]
SOURCE	NM_017434
SOURCE	NM_175940
SMD	Hs.272813
SAGE	Hs.272813
GO	peroxidase activity [Amigo]  peroxidase activity
GO	iron ion binding [Amigo]  iron ion binding
GO	calcium ion binding [Amigo]  calcium ion binding
GO	response to oxidative stress [Amigo]  response to oxidative stress
GO	electron carrier activity [Amigo]  electron carrier activity
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	NAD(P)H oxidase activity [Amigo]  NAD(P)H oxidase activity
GO	apical plasma membrane [Amigo]  apical plasma membrane
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	cytokine and chemokine mediated signaling pathway [Amigo]  cytokine and chemokine mediated signaling pathway
GO	heme binding [Amigo]  heme binding
GO	cuticle development [Amigo]  cuticle development
GO	hormone biosynthetic process [Amigo]  hormone biosynthetic process
GO	superoxide release [Amigo]  superoxide release
GO	hydrogen peroxide catabolic process [Amigo]  hydrogen peroxide catabolic process
GO	FAD binding [Amigo]  FAD binding
GO	NADP binding [Amigo]  NADP binding
GO	hydrogen peroxide biosynthetic process [Amigo]  hydrogen peroxide biosynthetic process
GO	response to cAMP [Amigo]  response to cAMP
GO	response to cAMP [Amigo]  response to cAMP
GO	oxidation reduction [Amigo]  oxidation reduction
PubGene	DUOX1
TreeFam	DUOX1
CTD	53905 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	DUOX1 Related clones (RZPD - Berlin)
	PubMed
PubMed	25 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:08:45 2008