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DUOX2 (dual oxidase 2)

Identity

Other namesLNOX2
NOXEF2
P138-TOX
TDH6
THOX2
HGNC (Hugo) DUOX2
LocusID (NCBI) 50506
Location 15q21.1
Location_base_pair Starts at 45384852 and ends at 45406359 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DUOX2   13273
Cards
Entrez_Gene (NCBI)DUOX2  50506  dual oxidase 2
GeneCards (Weizmann)DUOX2
Ensembl (Hinxton)ENSG00000140279 [Gene_View]  chr15:45384852-45406359 [Contig_View]  DUOX2 [Vega]
ICGC DataPortalENSG00000140279
cBioPortalDUOX2
AceView (NCBI)DUOX2
Genatlas (Paris)DUOX2
WikiGenes50506
SOURCE (Princeton)NM_014080
Genomic and cartography
GoldenPath (UCSC)DUOX2  -  15q21.1   chr15:45384852-45406359 -  15q21.1   [Description]    (hg19-Feb_2009)
EnsemblDUOX2 - 15q21.1 [CytoView]
Mapping of homologs : NCBIDUOX2 [Mapview]
OMIM606759   607200   
Gene and transcription
Genbank (Entrez)AB209010 AF181972 AF230496 AF267981 BI045475
RefSeq transcript (Entrez)NM_014080
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_009447 NT_010194 NW_001838218 NW_004929398
Consensus coding sequences : CCDS (NCBI)DUOX2
Cluster EST : UnigeneHs.71377 [ NCBI ]
CGAP (NCI)Hs.71377
Alternative Splicing : Fast-db (Paris)GSHG0010383
Alternative Splicing GalleryENSG00000140279
Gene ExpressionDUOX2 [ NCBI-GEO ]     DUOX2 [ SEEK ]   DUOX2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRD8 (Uniprot)
NextProtQ9NRD8  [Medical]
With graphics : InterProQ9NRD8
Splice isoforms : SwissVarQ9NRD8 (Swissvar)
Catalytic activity : Enzyme1.11.1.- [ Enzyme-Expasy ]   1.11.1.-1.11.1.- [ IntEnz-EBI ]   1.11.1.- [ BRENDA ]   1.11.1.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    FAD_FR (PS51384)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (EBI)EF-hand-dom_pair [organisation]   EF_Hand_1_Ca_BS [organisation]   EF_hand_dom [organisation]   FAD-bd_8 [organisation]   Fd_Rdtase_FAD-bd [organisation]   Fe3_Rdtase_TM_dom [organisation]   Fe_red_NAD-bd_6 [organisation]   Haem_peroxidase [organisation]   Haem_peroxidase_animal [organisation]   Haem_peroxidase_animal_subgr [organisation]   Riboflavin_synthase-like_b-brl [organisation]  
Related proteins : CluSTrQ9NRD8
Domain families : Pfam (Sanger)An_peroxidase (PF03098)    EF-hand_7 (PF13499)    FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam03098    pfam13499    pfam08022    pfam01794    pfam08030   
Domain families : Smart (EMBL)EFh (SM00054)  
DMDM Disease mutations50506
Blocks (Seattle)Q9NRD8
Human Protein AtlasENSG00000140279 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9NRD8
HPRD05997
IPIIPI00299627   IPI00556311   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRD8
IntAct (EBI)Q9NRD8
FunCoupENSG00000140279
BioGRIDDUOX2
InParanoidQ9NRD8
Interologous Interaction database Q9NRD8
IntegromeDBDUOX2
STRING (EMBL)DUOX2
Ontologies - Pathways
Ontology : AmiGOperoxidase activity  calcium ion binding  thyroid hormone generation  fertilization  response to virus  integral component of membrane  NAD(P)H oxidase activity  apical plasma membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  heme binding  bone mineralization  thyroid gland development  multicellular organism growth  cuticle development  hormone biosynthetic process  hydrogen peroxide catabolic process  inner ear development  adenohypophysis morphogenesis  response to cAMP  response to cAMP  oxidation-reduction process  extracellular vesicular exosome  
Ontology : EGO-EBIperoxidase activity  calcium ion binding  thyroid hormone generation  fertilization  response to virus  integral component of membrane  NAD(P)H oxidase activity  apical plasma membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  heme binding  bone mineralization  thyroid gland development  multicellular organism growth  cuticle development  hormone biosynthetic process  hydrogen peroxide catabolic process  inner ear development  adenohypophysis morphogenesis  response to cAMP  response to cAMP  oxidation-reduction process  extracellular vesicular exosome  
Pathways : KEGGThyroid hormone synthesis   
Protein Interaction DatabaseDUOX2
Wikipedia pathwaysDUOX2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DUOX2
snp3D : Map Gene to Disease50506
SNP (GeneSNP Utah)DUOX2
SNP : HGBaseDUOX2
Genetic variants : HAPMAPDUOX2
Exome VariantDUOX2
1000_GenomesDUOX2 
ICGC programENSG00000140279 
Somatic Mutations in Cancer : COSMICDUOX2 
CONAN: Copy Number AnalysisDUOX2 
Mutations and Diseases : HGMDDUOX2
Mutations and Diseases : intOGenDUOX2
Genomic VariantsDUOX2  DUOX2 [DGVbeta]
dbVarDUOX2
ClinVarDUOX2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM606759    607200   
MedgenDUOX2
GENETestsDUOX2
Disease Genetic AssociationDUOX2
Huge Navigator DUOX2 [HugePedia]  DUOX2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneDUOX2
Homology/Alignments : Family Browser (UCSC)DUOX2
Phylogenetic Trees/Animal Genes : TreeFamDUOX2
Chemical/Protein Interactions : CTD50506
Chemical/Pharm GKB GenePA27517
Clinical trialDUOX2
Cancer Resource (Charite)ENSG00000140279
Other databases
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
CoreMineDUOX2
iHOPDUOX2
OncoSearchDUOX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 18:48:41 CEST 2014

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