DUOX2 (dual oxidase 2)

2007-02-01  

Identity

HGNC
LOCATION
15q21.1
LOCUSID
ALIAS
LNOX2,NOXEF2,P138-TOX,TDH6,THOX2
FUSION GENES

Other Information

Locus ID:

NCBI: 50506
MIM: 606759
HGNC: 13273
Ensembl: ENSG00000140279

Variants:

dbSNP: 50506
ClinVar: 50506
TCGA: ENSG00000140279
COSMIC: DUOX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140279ENST00000389039X6RAN8
ENSG00000140279ENST00000603300Q9NRD8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Thyroxine biosynthesisREACTOMER-HSA-209968

References

Pubmed IDYearTitleCitations
250031942014Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.141
161116802005Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.108
166512682006Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.103
156777702005Regulated hydrogen peroxide production by Duox in human airway epithelial cells.101
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
155911622005Dual oxidase2 is expressed all along the digestive tract.79
197592862009DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.77
159728242005Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.76
182814782008Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.65
191446502009Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.56

Citation

Dessen P

DUOX2 (dual oxidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46154/duox2