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DUOX2 (dual oxidase 2)

Identity

Other namesLNOX2
NOXEF2
P138-TOX
TDH6
THOX2
HGNC (Hugo) DUOX2
LocusID (NCBI) 50506
Atlas_Id 46154
Location 15q21.1
Location_base_pair Starts at 45384852 and ends at 45406359 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DUOX2   13273
Cards
Entrez_Gene (NCBI)DUOX2  50506  dual oxidase 2
GeneCards (Weizmann)DUOX2
Ensembl hg19 (Hinxton)ENSG00000140279 [Gene_View]  chr15:45384852-45406359 [Contig_View]  DUOX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140279 [Gene_View]  chr15:45384852-45406359 [Contig_View]  DUOX2 [Vega]
ICGC DataPortalENSG00000140279
TCGA cBioPortalDUOX2
AceView (NCBI)DUOX2
Genatlas (Paris)DUOX2
WikiGenes50506
SOURCE (Princeton)DUOX2
Genomic and cartography
GoldenPath hg19 (UCSC)DUOX2  -     chr15:45384852-45406359 -  15q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DUOX2  -     15q21.1   [Description]    (hg38-Dec_2013)
EnsemblDUOX2 - 15q21.1 [CytoView hg19]  DUOX2 - 15q21.1 [CytoView hg38]
Mapping of homologs : NCBIDUOX2 [Mapview hg19]  DUOX2 [Mapview hg38]
OMIM606759   607200   
Gene and transcription
Genbank (Entrez)AB209010 AF181972 AF230496 AF267981 BI045475
RefSeq transcript (Entrez)NM_014080
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_009447 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)DUOX2
Cluster EST : UnigeneHs.71377 [ NCBI ]
CGAP (NCI)Hs.71377
Alternative Splicing : Fast-db (Paris)GSHG0010383
Alternative Splicing GalleryENSG00000140279
Gene ExpressionDUOX2 [ NCBI-GEO ]     DUOX2 [ SEEK ]   DUOX2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRD8 (Uniprot)
NextProtQ9NRD8  [Medical]
With graphics : InterProQ9NRD8
Splice isoforms : SwissVarQ9NRD8 (Swissvar)
Catalytic activity : Enzyme1.11.1.- [ Enzyme-Expasy ]   1.11.1.-1.11.1.- [ IntEnz-EBI ]   1.11.1.- [ BRENDA ]   1.11.1.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    FAD_FR (PS51384)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (EBI)DUOX2    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    FAD-bd_8    Fd_Rdtase_FAD-bd    Fe3_Rdtase_TM_dom    Fe_red_NAD-bd_6    Haem_peroxidase    Haem_peroxidase_animal    Riboflavin_synthase-like_b-brl   
Related proteins : CluSTrQ9NRD8
Domain families : Pfam (Sanger)An_peroxidase (PF03098)    EF-hand_7 (PF13499)    FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam03098    pfam13499    pfam08022    pfam01794    pfam08030   
Domain families : Smart (EMBL)EFh (SM00054)  
DMDM Disease mutations50506
Blocks (Seattle)Q9NRD8
Human Protein AtlasENSG00000140279
Peptide AtlasQ9NRD8
HPRD05997
IPIIPI00299627   IPI00556311   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRD8
IntAct (EBI)Q9NRD8
FunCoupENSG00000140279
BioGRIDDUOX2
IntegromeDBDUOX2
STRING (EMBL)DUOX2
Ontologies - Pathways
QuickGOQ9NRD8
Ontology : AmiGOperoxidase activity  calcium ion binding  thyroid hormone generation  response to oxidative stress  fertilization  response to virus  integral component of membrane  NAD(P)H oxidase activity  NAD(P)H oxidase activity  apical plasma membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  heme binding  bone mineralization  thyroid gland development  multicellular organism growth  cuticle development  hormone biosynthetic process  hydrogen peroxide catabolic process  inner ear development  adenohypophysis morphogenesis  response to cAMP  response to cAMP  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIperoxidase activity  calcium ion binding  thyroid hormone generation  response to oxidative stress  fertilization  response to virus  integral component of membrane  NAD(P)H oxidase activity  NAD(P)H oxidase activity  apical plasma membrane  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  heme binding  bone mineralization  thyroid gland development  multicellular organism growth  cuticle development  hormone biosynthetic process  hydrogen peroxide catabolic process  inner ear development  adenohypophysis morphogenesis  response to cAMP  response to cAMP  oxidation-reduction process  extracellular exosome  
Pathways : KEGGThyroid hormone synthesis   
Protein Interaction DatabaseDUOX2
DoCM (Curated mutations)DUOX2
Wikipedia pathwaysDUOX2
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerDUOX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUOX2
dbVarDUOX2
ClinVarDUOX2
1000_GenomesDUOX2 
Exome Variant ServerDUOX2
SNP (GeneSNP Utah)DUOX2
SNP : HGBaseDUOX2
Genetic variants : HAPMAPDUOX2
Genomic Variants (DGV)DUOX2 [DGVbeta]
Mutations
ICGC Data PortalDUOX2 
TCGA Data PortalDUOX2 
Tumor PortalDUOX2
Somatic Mutations in Cancer : COSMICDUOX2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:45384852-45406359
CONAN: Copy Number AnalysisDUOX2 
Mutations and Diseases : HGMDDUOX2
OMIM606759    607200   
MedgenDUOX2
NextProtQ9NRD8 [Medical]
GENETestsDUOX2
Disease Genetic AssociationDUOX2
Huge Navigator DUOX2 [HugePedia]  DUOX2 [HugeCancerGEM]
snp3D : Map Gene to Disease50506
DGIdb (Drug Gene Interaction db)DUOX2
General knowledge
Homologs : HomoloGeneDUOX2
Homology/Alignments : Family Browser (UCSC)DUOX2
Phylogenetic Trees/Animal Genes : TreeFamDUOX2
Chemical/Protein Interactions : CTD50506
Chemical/Pharm GKB GenePA27517
Clinical trialDUOX2
Cancer Resource (Charite)ENSG00000140279
Other databases
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
CoreMineDUOX2
GoPubMedDUOX2
iHOPDUOX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:21:07 CEST 2015

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