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DUOXA2 (dual oxidase maturation factor 2)

Identity

Alias (NCBI)SIMNIPHOM
TDH5
HGNC (Hugo) DUOXA2
LocusID (NCBI) 405753
Atlas_Id 45935
Location 15q21.1  [Link to chromosome band 15q21]
Location_base_pair Starts at 45114326 and ends at 45118421 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DUOXA2   32698
Cards
Entrez_Gene (NCBI)DUOXA2    dual oxidase maturation factor 2
AliasesSIMNIPHOM; TDH5
GeneCards (Weizmann)DUOXA2
Ensembl hg19 (Hinxton)ENSG00000140274 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140274 [Gene_View]  ENSG00000140274 [Sequence]  chr15:45114326-45118421 [Contig_View]  DUOXA2 [Vega]
ICGC DataPortalENSG00000140274
TCGA cBioPortalDUOXA2
AceView (NCBI)DUOXA2
Genatlas (Paris)DUOXA2
SOURCE (Princeton)DUOXA2
Genetics Home Reference (NIH)DUOXA2
Genomic and cartography
GoldenPath hg38 (UCSC)DUOXA2  -     chr15:45114326-45118421 +  15q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUOXA2  -     15q21.1   [Description]    (hg19-Feb_2009)
GoldenPathDUOXA2 - 15q21.1 [CytoView hg19]  DUOXA2 - 15q21.1 [CytoView hg38]
ImmunoBaseENSG00000140274
Genome Data Viewer NCBIDUOXA2 [Mapview hg19]  
OMIM274900   612772   
Gene and transcription
Genbank (Entrez)AK303955 BC137465 BM987789 BX537581 DB243076
RefSeq transcript (Entrez)NM_207581
Consensus coding sequences : CCDS (NCBI)DUOXA2
Gene ExpressionDUOXA2 [ NCBI-GEO ]   DUOXA2 [ EBI - ARRAY_EXPRESS ]   DUOXA2 [ SEEK ]   DUOXA2 [ MEM ]
Gene Expression Viewer (FireBrowse)DUOXA2 [ Firebrowse - Broad ]
GenevisibleExpression of DUOXA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)405753
GTEX Portal (Tissue expression)DUOXA2
Human Protein AtlasENSG00000140274-DUOXA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ1HG44   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ1HG44  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ1HG44
PhosPhoSitePlusQ1HG44
Domains : Interpro (EBI)Dual_oxidase_maturation_fac   
Domain families : Pfam (Sanger)DuoxA (PF10204)   
Domain families : Pfam (NCBI)pfam10204   
Conserved Domain (NCBI)DUOXA2
SuperfamilyQ1HG44
AlphaFold pdb e-kbQ1HG44   
Human Protein Atlas [tissue]ENSG00000140274-DUOXA2 [tissue]
HPRD14224
Protein Interaction databases
DIP (DOE-UCLA)Q1HG44
IntAct (EBI)Q1HG44
BioGRIDDUOXA2
STRING (EMBL)DUOXA2
ZODIACDUOXA2
Ontologies - Pathways
QuickGOQ1HG44
Ontology : AmiGOprotein binding  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  plasma membrane  plasma membrane  protein localization  positive regulation of hydrogen peroxide biosynthetic process  positive regulation of hydrogen peroxide biosynthetic process  protein transport  membrane  integral component of membrane  enzyme binding  cell leading edge  cellular protein localization  hydrogen peroxide metabolic process  apical part of cell  regulation of inflammatory response  protein maturation  positive regulation of cell motility  regulation of thyroid hormone generation  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  plasma membrane  plasma membrane  protein localization  positive regulation of hydrogen peroxide biosynthetic process  positive regulation of hydrogen peroxide biosynthetic process  protein transport  membrane  integral component of membrane  enzyme binding  cell leading edge  cellular protein localization  hydrogen peroxide metabolic process  apical part of cell  regulation of inflammatory response  protein maturation  positive regulation of cell motility  regulation of thyroid hormone generation  
Pathways : KEGGThyroid hormone synthesis   
NDEx NetworkDUOXA2
Atlas of Cancer Signalling NetworkDUOXA2
Wikipedia pathwaysDUOXA2
Orthology - Evolution
OrthoDB405753
GeneTree (enSembl)ENSG00000140274
Phylogenetic Trees/Animal Genes : TreeFamDUOXA2
Homologs : HomoloGeneDUOXA2
Homology/Alignments : Family Browser (UCSC)DUOXA2
Gene fusions - Rearrangements
Fusion : QuiverDUOXA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUOXA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUOXA2
dbVarDUOXA2
ClinVarDUOXA2
MonarchDUOXA2
1000_GenomesDUOXA2 
Exome Variant ServerDUOXA2
GNOMAD BrowserENSG00000140274
Varsome BrowserDUOXA2
ACMGDUOXA2 variants
VarityQ1HG44
Genomic Variants (DGV)DUOXA2 [DGVbeta]
DECIPHERDUOXA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUOXA2 
Mutations
ICGC Data PortalDUOXA2 
TCGA Data PortalDUOXA2 
Broad Tumor PortalDUOXA2
OASIS PortalDUOXA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUOXA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDUOXA2
Mutations and Diseases : HGMDDUOXA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDUOXA2
DgiDB (Drug Gene Interaction Database)DUOXA2
DoCM (Curated mutations)DUOXA2
CIViC (Clinical Interpretations of Variants in Cancer)DUOXA2
Cancer3DDUOXA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM274900    612772   
Orphanet12671   
DisGeNETDUOXA2
MedgenDUOXA2
Genetic Testing Registry DUOXA2
NextProtQ1HG44 [Medical]
GENETestsDUOXA2
Target ValidationDUOXA2
Huge Navigator DUOXA2 [HugePedia]
ClinGenDUOXA2
Clinical trials, drugs, therapy
MyCancerGenomeDUOXA2
Protein Interactions : CTDDUOXA2
Pharm GKB GenePA145008523
PharosQ1HG44
Clinical trialDUOXA2
Miscellaneous
canSAR (ICR)DUOXA2
HarmonizomeDUOXA2
DataMed IndexDUOXA2
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDUOXA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:07:25 CEST 2021

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