DUS2 (dihydrouridine synthase 2)

2014-08-01  

Identity

HGNC
DUS2
LOCATION
16q22.1
LOCUSID
54920
ALIAS
DUS2L,SMM1,URLC8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54920
MIM: 609707
HGNC: 26014
Ensembl: ENSG00000167264

Variants:

dbSNP: 54920
ClinVar: 54920
TCGA: ENSG00000167264
COSMIC: DUS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167264ENST00000358896Q9NX74
ENSG00000167264ENST00000358896A0A024R6Z7
ENSG00000167264ENST00000432752E7EUN9
ENSG00000167264ENST00000561965H3BTR3
ENSG00000167264ENST00000562246J3QLD5
ENSG00000167264ENST00000564781H3BSF3
ENSG00000167264ENST00000565263Q9NX74
ENSG00000167264ENST00000565263A0A024R6Z7
ENSG00000167264ENST00000566306H3BM64
ENSG00000167264ENST00000567100H3BMK6
ENSG00000167264ENST00000568099H3BQX4
ENSG00000167264ENST00000569289H3BRI6
ENSG00000167264ENST00000570709I3L4H0
ENSG00000167264ENST00000571081I3L1K5
ENSG00000167264ENST00000575677I3L4Y9
ENSG00000167264ENST00000576994I3L0K0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
180966162008Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR.14
264299682015An extended dsRBD is required for post-transcriptional modification in human tRNAs.3
224422372012Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase.2
261439272015From bacterial to human dihydrouridine synthase: automated structure determination.2
306055272019Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.0

Citation

Dessen P

DUS2 (dihydrouridine synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54269/dus2