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DUS2 (dihydrouridine synthase 2)

Identity

Alias_namesDUS2L
dihydrouridine synthase 2-like (SMM1, S. cerevisiae)
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
dihydrouridine synthase 2-like
Alias_symbol (synonym)FLJ20399
SMM1
Other aliasURLC8
HGNC (Hugo) DUS2
LocusID (NCBI) 54920
Atlas_Id 54269
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 68022944 and ends at 68079323 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP6V0D1 (16q22.1) / DUS2 (16q22.1)DUS2 (16q22.1) / BEAN1 (16q21)DUS2 (16q22.1) / HSD11B2 (16q22.1)
DUS2 (16q22.1) / RLTPR (16q22.1)DUS2 (16q22.1) / UNC5C (4q22.3)TANGO6 (16q22.1) / DUS2 (16q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(4;16)(q22;q22) DUS2/UNC5C
t(16;16)(q21;q22) DUS2/BEAN1
t(16;16)(q22;q22) ATP6V0D1/DUS2
t(16;16)(q22;q22) DUS2/HSD11B2

External links

Nomenclature
HGNC (Hugo)DUS2   26014
Cards
Entrez_Gene (NCBI)DUS2  54920  dihydrouridine synthase 2
AliasesDUS2L; SMM1; URLC8
GeneCards (Weizmann)DUS2
Ensembl hg19 (Hinxton)ENSG00000167264 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167264 [Gene_View]  ENSG00000167264 [Sequence]  chr16:68022944-68079323 [Contig_View]  DUS2 [Vega]
ICGC DataPortalENSG00000167264
TCGA cBioPortalDUS2
AceView (NCBI)DUS2
Genatlas (Paris)DUS2
WikiGenes54920
SOURCE (Princeton)DUS2
Genetics Home Reference (NIH)DUS2
Genomic and cartography
GoldenPath hg38 (UCSC)DUS2  -     chr16:68022944-68079323 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUS2  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblDUS2 - 16q22.1 [CytoView hg19]  DUS2 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIDUS2 [Mapview hg19]  DUS2 [Mapview hg38]
OMIM609707   
Gene and transcription
Genbank (Entrez)AB101210 AK000406 AK290578 AK296663 BC006527
RefSeq transcript (Entrez)NM_001271762 NM_001271763 NM_017803
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUS2
Cluster EST : UnigeneHs.744492 [ NCBI ]
CGAP (NCI)Hs.744492
Alternative Splicing GalleryENSG00000167264
Gene ExpressionDUS2 [ NCBI-GEO ]   DUS2 [ EBI - ARRAY_EXPRESS ]   DUS2 [ SEEK ]   DUS2 [ MEM ]
Gene Expression Viewer (FireBrowse)DUS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54920
GTEX Portal (Tissue expression)DUS2
Human Protein AtlasENSG00000167264-DUS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NX74   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NX74  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NX74
Splice isoforms : SwissVarQ9NX74
Catalytic activity : Enzyme1.3.1.- [ Enzyme-Expasy ]   1.3.1.-1.3.1.- [ IntEnz-EBI ]   1.3.1.- [ BRENDA ]   1.3.1.- [ KEGG ]   
PhosPhoSitePlusQ9NX74
Domaine pattern : Prosite (Expaxy)UPF0034 (PS01136)   
Domains : Interpro (EBI)Aldolase_TIM    dsRBD_dom    tRNA_hU_synthase    tRNA_hU_synthase_CS   
Domain families : Pfam (Sanger)dsrm (PF00035)    Dus (PF01207)   
Domain families : Pfam (NCBI)pfam00035    pfam01207   
Domain families : Smart (EMBL)DSRM (SM00358)  
Conserved Domain (NCBI)DUS2
DMDM Disease mutations54920
Blocks (Seattle)DUS2
PDB (SRS)4WFS    4WFT    4XP7   
PDB (PDBSum)4WFS    4WFT    4XP7   
PDB (IMB)4WFS    4WFT    4XP7   
PDB (RSDB)4WFS    4WFT    4XP7   
Structural Biology KnowledgeBase4WFS    4WFT    4XP7   
SCOP (Structural Classification of Proteins)4WFS    4WFT    4XP7   
CATH (Classification of proteins structures)4WFS    4WFT    4XP7   
SuperfamilyQ9NX74
Human Protein Atlas [tissue]ENSG00000167264-DUS2 [tissue]
Peptide AtlasQ9NX74
HPRD08624
IPIIPI00015804   IPI00909876   
Protein Interaction databases
DIP (DOE-UCLA)Q9NX74
IntAct (EBI)Q9NX74
FunCoupENSG00000167264
BioGRIDDUS2
STRING (EMBL)DUS2
ZODIACDUS2
Ontologies - Pathways
QuickGOQ9NX74
Ontology : AmiGOtRNA dihydrouridine synthesis  double-stranded RNA binding  protein kinase inhibitor activity  protein binding  mitochondrion  endoplasmic reticulum  cytosol  negative regulation of protein kinase activity  tRNA dihydrouridine synthase activity  flavin adenine dinucleotide binding  oxidation-reduction process  negative regulation of cell death  
Ontology : EGO-EBItRNA dihydrouridine synthesis  double-stranded RNA binding  protein kinase inhibitor activity  protein binding  mitochondrion  endoplasmic reticulum  cytosol  negative regulation of protein kinase activity  tRNA dihydrouridine synthase activity  flavin adenine dinucleotide binding  oxidation-reduction process  negative regulation of cell death  
NDEx NetworkDUS2
Atlas of Cancer Signalling NetworkDUS2
Wikipedia pathwaysDUS2
Orthology - Evolution
OrthoDB54920
GeneTree (enSembl)ENSG00000167264
Phylogenetic Trees/Animal Genes : TreeFamDUS2
HOVERGENQ9NX74
HOGENOMQ9NX74
Homologs : HomoloGeneDUS2
Homology/Alignments : Family Browser (UCSC)DUS2
Gene fusions - Rearrangements
Fusion : MitelmanATP6V0D1/DUS2 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion : MitelmanDUS2/BEAN1 [16q22.1/16q21]  [t(16;16)(q21;q22)]  
Fusion : MitelmanDUS2/HSD11B2 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion : MitelmanDUS2/RLTPR [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion : MitelmanDUS2/UNC5C [16q22.1/4q22.3]  [t(4;16)(q22;q22)]  
Fusion : QuiverDUS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUS2
dbVarDUS2
ClinVarDUS2
1000_GenomesDUS2 
Exome Variant ServerDUS2
ExAC (Exome Aggregation Consortium)ENSG00000167264
GNOMAD BrowserENSG00000167264
Genetic variants : HAPMAP54920
Genomic Variants (DGV)DUS2 [DGVbeta]
DECIPHERDUS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUS2 
Mutations
ICGC Data PortalDUS2 
TCGA Data PortalDUS2 
Broad Tumor PortalDUS2
OASIS PortalDUS2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDUS2
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DUS2
DgiDB (Drug Gene Interaction Database)DUS2
DoCM (Curated mutations)DUS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUS2 (select a term)
intoGenDUS2
Cancer3DDUS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609707   
Orphanet
DisGeNETDUS2
MedgenDUS2
Genetic Testing Registry DUS2
NextProtQ9NX74 [Medical]
TSGene54920
GENETestsDUS2
Target ValidationDUS2
Huge Navigator DUS2 [HugePedia]
snp3D : Map Gene to Disease54920
BioCentury BCIQDUS2
ClinGenDUS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54920
Chemical/Pharm GKB GenePA142671937
Clinical trialDUS2
Miscellaneous
canSAR (ICR)DUS2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUS2
EVEXDUS2
GoPubMedDUS2
iHOPDUS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:23:25 CEST 2018
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