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DUS4L (dihydrouridine synthase 4 like)

Identity

Alias_namesdihydrouridine synthase 4-like (S. cerevisiae)
Alias_symbol (synonym)PP35
DUS4
Other alias
HGNC (Hugo) DUS4L
LocusID (NCBI) 11062
Atlas_Id 54270
Location 7q22.3  [Link to chromosome band 7q22]
Location_base_pair Starts at 107563957 and ends at 107578523 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKRD7 (7q31.31) / DUS4L (7q22.3)DUS4L (7q22.3) / ANKRD7 (7q31.31)DUS4L (7q22.3) / BCAP29 (7q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Squamous Cell Carcinoma
DUS4L/BCAP29 (7q22)
DUS4L/BCAP29 (7q22)
t(7;7)(q22;q31) DUS4L/ANKRD7
t(7;7)(q22;q31) ANKRD7/DUS4L


External links

Nomenclature
HGNC (Hugo)DUS4L   21517
Cards
Entrez_Gene (NCBI)DUS4L  11062  dihydrouridine synthase 4 like
AliasesDUS4; PP35
GeneCards (Weizmann)DUS4L
Ensembl hg19 (Hinxton)ENSG00000105865 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105865 [Gene_View]  ENSG00000105865 [Sequence]  chr7:107563957-107578523 [Contig_View]  DUS4L [Vega]
ICGC DataPortalENSG00000105865
TCGA cBioPortalDUS4L
AceView (NCBI)DUS4L
Genatlas (Paris)DUS4L
WikiGenes11062
SOURCE (Princeton)DUS4L
Genetics Home Reference (NIH)DUS4L
Genomic and cartography
GoldenPath hg38 (UCSC)DUS4L  -     chr7:107563957-107578523 +  7q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUS4L  -     7q22.3   [Description]    (hg19-Feb_2009)
EnsemblDUS4L - 7q22.3 [CytoView hg19]  DUS4L - 7q22.3 [CytoView hg38]
Mapping of homologs : NCBIDUS4L [Mapview hg19]  DUS4L [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA157330 AK127802 AK294095 AK297195 AK308472
RefSeq transcript (Entrez)NM_001270419 NM_181581
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUS4L
Cluster EST : UnigeneHs.97627 [ NCBI ]
CGAP (NCI)Hs.97627
Alternative Splicing GalleryENSG00000105865
Gene ExpressionDUS4L [ NCBI-GEO ]   DUS4L [ EBI - ARRAY_EXPRESS ]   DUS4L [ SEEK ]   DUS4L [ MEM ]
Gene Expression Viewer (FireBrowse)DUS4L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11062
GTEX Portal (Tissue expression)DUS4L
Human Protein AtlasENSG00000105865-DUS4L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95620   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95620  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95620
Splice isoforms : SwissVarO95620
Catalytic activity : Enzyme1.3.1.- [ Enzyme-Expasy ]   1.3.1.-1.3.1.- [ IntEnz-EBI ]   1.3.1.- [ BRENDA ]   1.3.1.- [ KEGG ]   
PhosPhoSitePlusO95620
Domaine pattern : Prosite (Expaxy)UPF0034 (PS01136)   
Domains : Interpro (EBI)Aldolase_TIM    DUS-like_FMN-bd    tRNA_hU_synthase    tRNA_hU_synthase_CS   
Domain families : Pfam (Sanger)Dus (PF01207)   
Domain families : Pfam (NCBI)pfam01207   
Conserved Domain (NCBI)DUS4L
DMDM Disease mutations11062
Blocks (Seattle)DUS4L
SuperfamilyO95620
Human Protein Atlas [tissue]ENSG00000105865-DUS4L [tissue]
Peptide AtlasO95620
HPRD17886
IPIIPI00021410   IPI00783809   IPI00924597   IPI00925668   IPI00925405   
Protein Interaction databases
DIP (DOE-UCLA)O95620
IntAct (EBI)O95620
FunCoupENSG00000105865
BioGRIDDUS4L
STRING (EMBL)DUS4L
ZODIACDUS4L
Ontologies - Pathways
QuickGOO95620
Ontology : AmiGOtRNA dihydrouridine synthesis  tRNA dihydrouridine synthase activity  flavin adenine dinucleotide binding  oxidation-reduction process  
Ontology : EGO-EBItRNA dihydrouridine synthesis  tRNA dihydrouridine synthase activity  flavin adenine dinucleotide binding  oxidation-reduction process  
NDEx NetworkDUS4L
Atlas of Cancer Signalling NetworkDUS4L
Wikipedia pathwaysDUS4L
Orthology - Evolution
OrthoDB11062
GeneTree (enSembl)ENSG00000105865
Phylogenetic Trees/Animal Genes : TreeFamDUS4L
HOVERGENO95620
HOGENOMO95620
Homologs : HomoloGeneDUS4L
Homology/Alignments : Family Browser (UCSC)DUS4L
Gene fusions - Rearrangements
Fusion : MitelmanANKRD7/DUS4L [7q31.31/7q22.3]  [t(7;7)(q22;q31)]  
Fusion : MitelmanDUS4L/ANKRD7 [7q22.3/7q31.31]  [t(7;7)(q22;q31)]  
Fusion : MitelmanDUS4L/BCAP29 [7q22.3/7q22.3]  [t(7;7)(q22;q22)]  
Fusion : QuiverDUS4L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUS4L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUS4L
dbVarDUS4L
ClinVarDUS4L
1000_GenomesDUS4L 
Exome Variant ServerDUS4L
ExAC (Exome Aggregation Consortium)ENSG00000105865
GNOMAD BrowserENSG00000105865
Varsome BrowserDUS4L
Genetic variants : HAPMAP11062
Genomic Variants (DGV)DUS4L [DGVbeta]
DECIPHERDUS4L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUS4L 
Mutations
ICGC Data PortalDUS4L 
TCGA Data PortalDUS4L 
Broad Tumor PortalDUS4L
OASIS PortalDUS4L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUS4L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDUS4L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUS4L
DgiDB (Drug Gene Interaction Database)DUS4L
DoCM (Curated mutations)DUS4L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUS4L (select a term)
intoGenDUS4L
Cancer3DDUS4L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETDUS4L
MedgenDUS4L
Genetic Testing Registry DUS4L
NextProtO95620 [Medical]
TSGene11062
GENETestsDUS4L
Target ValidationDUS4L
Huge Navigator DUS4L [HugePedia]
snp3D : Map Gene to Disease11062
BioCentury BCIQDUS4L
ClinGenDUS4L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11062
Chemical/Pharm GKB GenePA142671939
Clinical trialDUS4L
Miscellaneous
canSAR (ICR)DUS4L (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUS4L
EVEXDUS4L
GoPubMedDUS4L
iHOPDUS4L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:03:29 CET 2018

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