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DUSP10 (dual specificity phosphatase 10)

Written2010-05Larisa Nonn
Department of Pathology, University of Illinois at Chicago, 840 S. Wood St., Room 130 CSN, MC 847, Chicago, IL 60612, USA

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)MKP-5
MKP5
Other alias
HGNC (Hugo) DUSP10
LocusID (NCBI) 11221
Atlas_Id 49913
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 221701420 and ends at 221742176 bp from pter ( according to hg19-Feb_2009)  [Mapping DUSP10.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP10 (1q41) / GNAL (18p11.21)DUSP10 (1q41) / PRDM16 (1p36.32)PLXNA2 (1q32.2) / DUSP10 (1q41)
Note DUSP10 is also known as MAP Kinase Phosphatase 5.

DNA/RNA

 
  DUSP10 mRNA transcript variants.
Description The DUSP10 gene consists of 5 exons and 4 introns spanning 40 kb.
Transcription There are three mRNA transcript variants for DUSP10 and two protein isoforms. Variant 1 is the full length protein, isoform a. Variants 2 and 3 have different 5' mRNA transcripts, but the same start site in exon 3 and are missing the N-terminus. Variants 2 and 3 only contain the C-terminal catalytic domain and code for isoform b.
The ATG site is on Exon 2.
DUSP10 Variant 1 (isoform a), NM_007207.3.
DUSP10 Variant 2 (isoform b), NM_144728.1.
DUSP10 Variant 3 (isoform b), NM_144729.1.

Protein

Note Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
DUSP10 gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK.
Description DUSP10 gene is translated into two different protein products. Transcript variant 1 codes for the full-length DUSP10 isoform a (NP_009138.1) of 482 amino acids and a molecular weight of 52 kDa. Transcript variants 2 and 3 encode for a shorter protein, DUSP10 isoform b (NP_653329.1), that is 140 amino acids in length.
Expression DUSP10 mRNA is widely expressed in liver, skeletal muscle, retina, macrophages, colon, fetal heart, spleen, infant brain, pregnant uterus, prostate epithelium and ovarian tumors.
DUSP10 mRNA is inducible by oxidative stress via JNK and ATF activation.
Localisation DUSP10 is present in both the cytoplasm and nucleus of the cell.
Function DUSP10 is a MAP kinase phosphatase with substrate specificy for jun N-terminal kinase (JNK) and p38.
Homology The DUSP10 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish.

Mutations

Note There are no characterized mutations in DUSP10.

Implicated in

Note
  
Entity Prostate cancer
Note To date, DUSP10 levels or mutation have not been associated with any disease. However, DUSP10 mRNA levels were lower in prostate cell lines derived from malignant tumor than from cells derived from normal prostate tissue (Nonn et al., 2006). Additionally, DUSP10 mRNA levels are inducible in prostate cells by treatment with 1,25-dihydoxyvitamin D, curcumin, reseveratrol and gingerol (Nonn et al., 2006; Nonn et al., 2007).
  

Bibliography

Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase.
Jeong DG, Yoon TS, Kim JH, Shim MY, Jung SK, Son JH, Ryu SE, Kim SJ.
J Mol Biol. 2006 Jul 28;360(5):946-55. Epub 2006 Jun 9.
PMID 16806267
 
Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10.
Masuda K, Shima H, Kikuchi K, Watanabe Y, Matsuda Y.
Cytogenet Cell Genet. 2000;90(1-2):71-4.
PMID 11060451
 
Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells.
Nonn L, Duong D, Peehl DM.
Carcinogenesis. 2007 Jun;28(6):1188-96. Epub 2006 Dec 6.
PMID 17151092
 
Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.
Nonn L, Peng L, Feldman D, Peehl DM.
Cancer Res. 2006 Apr 15;66(8):4516-24.
PMID 16618780
 
Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.
Tanoue T, Moriguchi T, Nishida E.
J Biol Chem. 1999 Jul 9;274(28):19949-56.
PMID 10391943
 
Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress.
Teng CH, Huang WN, Meng TC.
J Biol Chem. 2007 Sep 28;282(39):28395-407. Epub 2007 Aug 6.
PMID 17681939
 
MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.
Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A.
Oncogene. 1999 Nov 25;18(50):6981-8.
PMID 10597297
 
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5.
Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong C.
Nature. 2004 Aug 12;430(7001):793-7.
PMID 15306813
 

Citation

This paper should be referenced as such :
Nonn, L
DUSP10 (dual specificity phosphatase 10)
Atlas Genet Cytogenet Oncol Haematol. 2011;15(2):148-149.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/DUSP10ID49913ch1q41.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  der(1)t(1;1)(p36;q11-q32) in hematopoietic malignancies
t(1;1)(p36;q41) DUSP10/PRDM16
1q translocations (unbalanced) in myeloid malignancies


External links

Nomenclature
HGNC (Hugo)DUSP10   3065
Cards
AtlasDUSP10ID49913ch1q41
Entrez_Gene (NCBI)DUSP10  11221  dual specificity phosphatase 10
AliasesMKP-5; MKP5
GeneCards (Weizmann)DUSP10
Ensembl hg19 (Hinxton)ENSG00000143507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143507 [Gene_View]  chr1:221701420-221742176 [Contig_View]  DUSP10 [Vega]
ICGC DataPortalENSG00000143507
TCGA cBioPortalDUSP10
AceView (NCBI)DUSP10
Genatlas (Paris)DUSP10
WikiGenes11221
SOURCE (Princeton)DUSP10
Genetics Home Reference (NIH)DUSP10
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP10  -     chr1:221701420-221742176 -  1q41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP10  -     1q41   [Description]    (hg19-Feb_2009)
EnsemblDUSP10 - 1q41 [CytoView hg19]  DUSP10 - 1q41 [CytoView hg38]
Mapping of homologs : NCBIDUSP10 [Mapview hg19]  DUSP10 [Mapview hg38]
OMIM608867   
Gene and transcription
Genbank (Entrez)AA431025 AB026436 AF179212 AI220242 AI261880
RefSeq transcript (Entrez)NM_007207 NM_144728 NM_144729
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUSP10
Cluster EST : UnigeneHs.732301 [ NCBI ]
CGAP (NCI)Hs.732301
Alternative Splicing GalleryENSG00000143507
Gene ExpressionDUSP10 [ NCBI-GEO ]   DUSP10 [ EBI - ARRAY_EXPRESS ]   DUSP10 [ SEEK ]   DUSP10 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11221
GTEX Portal (Tissue expression)DUSP10
Human Protein AtlasENSG00000143507-DUSP10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6W6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6W6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6W6
Splice isoforms : SwissVarQ9Y6W6
PhosPhoSitePlusQ9Y6W6
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Atypical_DUSP    Dual-sp_phosphatase_cat-dom    DUSP    MKP    Prot-tyrosine_phosphatase-like    Rhodanese-like_dom    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00782    pfam00581   
Domain families : Smart (EMBL)DSPc (SM00195)  RHOD (SM00450)  
Conserved Domain (NCBI)DUSP10
DMDM Disease mutations11221
Blocks (Seattle)DUSP10
PDB (SRS)1ZZW    2OUC    2OUD    3TG1   
PDB (PDBSum)1ZZW    2OUC    2OUD    3TG1   
PDB (IMB)1ZZW    2OUC    2OUD    3TG1   
PDB (RSDB)1ZZW    2OUC    2OUD    3TG1   
Structural Biology KnowledgeBase1ZZW    2OUC    2OUD    3TG1   
SCOP (Structural Classification of Proteins)1ZZW    2OUC    2OUD    3TG1   
CATH (Classification of proteins structures)1ZZW    2OUC    2OUD    3TG1   
SuperfamilyQ9Y6W6
Human Protein Atlas [tissue]ENSG00000143507-DUSP10 [tissue]
Peptide AtlasQ9Y6W6
HPRD12320
IPIIPI00026987   IPI00939755   IPI00158733   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6W6
IntAct (EBI)Q9Y6W6
FunCoupENSG00000143507
BioGRIDDUSP10
STRING (EMBL)DUSP10
ZODIACDUSP10
Ontologies - Pathways
QuickGOQ9Y6W6
Ontology : AmiGOinactivation of MAPK activity  regulation of adaptive immune response  phosphoprotein phosphatase activity  protein tyrosine phosphatase activity  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  protein dephosphorylation  response to stress  JNK cascade  dephosphorylation  nuclear speck  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  response to lipopolysaccharide  MAP kinase phosphatase activity  peptidyl-tyrosine dephosphorylation  negative regulation of JUN kinase activity  negative regulation of protein kinase activity by regulation of protein phosphorylation  positive regulation of regulatory T cell differentiation  oligodendrocyte differentiation  negative regulation of oligodendrocyte differentiation  negative regulation of respiratory burst involved in inflammatory response  regulation of brown fat cell differentiation  
Ontology : EGO-EBIinactivation of MAPK activity  regulation of adaptive immune response  phosphoprotein phosphatase activity  protein tyrosine phosphatase activity  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  protein dephosphorylation  response to stress  JNK cascade  dephosphorylation  nuclear speck  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  response to lipopolysaccharide  MAP kinase phosphatase activity  peptidyl-tyrosine dephosphorylation  negative regulation of JUN kinase activity  negative regulation of protein kinase activity by regulation of protein phosphorylation  positive regulation of regulatory T cell differentiation  oligodendrocyte differentiation  negative regulation of oligodendrocyte differentiation  negative regulation of respiratory burst involved in inflammatory response  regulation of brown fat cell differentiation  
Pathways : KEGGMAPK signaling pathway   
REACTOMEQ9Y6W6 [protein]
REACTOME PathwaysR-HSA-5675221 [pathway]   
NDEx NetworkDUSP10
Atlas of Cancer Signalling NetworkDUSP10
Wikipedia pathwaysDUSP10
Orthology - Evolution
OrthoDB11221
GeneTree (enSembl)ENSG00000143507
Phylogenetic Trees/Animal Genes : TreeFamDUSP10
HOVERGENQ9Y6W6
HOGENOMQ9Y6W6
Homologs : HomoloGeneDUSP10
Homology/Alignments : Family Browser (UCSC)DUSP10
Gene fusions - Rearrangements
Fusion : MitelmanDUSP10/PRDM16 [1q41/1p36.32]  
Fusion : MitelmanPLXNA2/DUSP10 [1q32.2/1q41]  [t(1;1)(q32;q41)]  
Fusion: TCGAPLXNA2 1q32.2 DUSP10 1q41 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP10
dbVarDUSP10
ClinVarDUSP10
1000_GenomesDUSP10 
Exome Variant ServerDUSP10
ExAC (Exome Aggregation Consortium)ENSG00000143507
GNOMAD BrowserENSG00000143507
Genetic variants : HAPMAP11221
Genomic Variants (DGV)DUSP10 [DGVbeta]
DECIPHERDUSP10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP10 
Mutations
ICGC Data PortalDUSP10 
TCGA Data PortalDUSP10 
Broad Tumor PortalDUSP10
OASIS PortalDUSP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDUSP10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP10
DgiDB (Drug Gene Interaction Database)DUSP10
DoCM (Curated mutations)DUSP10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP10 (select a term)
intoGenDUSP10
NCG5 (London)DUSP10
Cancer3DDUSP10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608867   
Orphanet
MedgenDUSP10
Genetic Testing Registry DUSP10
NextProtQ9Y6W6 [Medical]
TSGene
GENETestsDUSP10
Target ValidationDUSP10
Huge Navigator DUSP10 [HugePedia]
snp3D : Map Gene to Disease11221
BioCentury BCIQDUSP10
ClinGenDUSP10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11221
Chemical/Pharm GKB GenePA27520
Clinical trialDUSP10
Miscellaneous
canSAR (ICR)DUSP10 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP10
EVEXDUSP10
GoPubMedDUSP10
iHOPDUSP10
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 12 16:20:41 CEST 2017

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