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DUSP14 (dual specificity phosphatase 14)

Identity

Alias_symbol (synonym)MKP-L
MKP6
Other alias
HGNC (Hugo) DUSP14
LocusID (NCBI) 11072
Atlas_Id 40372
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 37489845 and ends at 37513486 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COBL (7p12.1) / DUSP14 (17q12)DUSP14 (17q12) / EME1 (17q21.33)NLK (17q11.2) / DUSP14 (17q12)
COBL 7p12.1 / DUSP14 17q12DUSP14 17q12 / EME1 17q21.33NLK 17q11.2 / DUSP14 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DUSP14   17007
Cards
Entrez_Gene (NCBI)DUSP14  11072  dual specificity phosphatase 14
AliasesMKP-L; MKP6
GeneCards (Weizmann)DUSP14
Ensembl hg19 (Hinxton)ENSG00000276023 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000276023 [Gene_View]  chr17:37489845-37513486 [Contig_View]  DUSP14 [Vega]
ICGC DataPortalENSG00000276023
TCGA cBioPortalDUSP14
AceView (NCBI)DUSP14
Genatlas (Paris)DUSP14
WikiGenes11072
SOURCE (Princeton)DUSP14
Genetics Home Reference (NIH)DUSP14
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP14  -     chr17:37489845-37513486 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP14  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblDUSP14 - 17q12 [CytoView hg19]  DUSP14 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIDUSP14 [Mapview hg19]  DUSP14 [Mapview hg38]
OMIM606618   
Gene and transcription
Genbank (Entrez)AF038844 AF120032 AK027210 AK314894 BC000370
RefSeq transcript (Entrez)NM_007026
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_187614
Consensus coding sequences : CCDS (NCBI)DUSP14
Cluster EST : UnigeneHs.91448 [ NCBI ]
CGAP (NCI)Hs.91448
Alternative Splicing GalleryENSG00000276023
Gene ExpressionDUSP14 [ NCBI-GEO ]   DUSP14 [ EBI - ARRAY_EXPRESS ]   DUSP14 [ SEEK ]   DUSP14 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11072
GTEX Portal (Tissue expression)DUSP14
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95147   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95147  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95147
Splice isoforms : SwissVarO95147
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusO95147
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Atypical_DUSP    Atypical_DUSP_famB    Dual-sp_phosphatase_cat-dom    DUSP    Prot-tyrosine_phosphatase-like    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Domain families : Smart (EMBL)DSPc (SM00195)  
Conserved Domain (NCBI)DUSP14
DMDM Disease mutations11072
Blocks (Seattle)DUSP14
PDB (SRS)2WGP   
PDB (PDBSum)2WGP   
PDB (IMB)2WGP   
PDB (RSDB)2WGP   
Structural Biology KnowledgeBase2WGP   
SCOP (Structural Classification of Proteins)2WGP   
CATH (Classification of proteins structures)2WGP   
SuperfamilyO95147
Human Protein AtlasENSG00000276023
Peptide AtlasO95147
HPRD09427
IPIIPI00013031   
Protein Interaction databases
DIP (DOE-UCLA)O95147
IntAct (EBI)O95147
FunCoupENSG00000276023
BioGRIDDUSP14
STRING (EMBL)DUSP14
ZODIACDUSP14
Ontologies - Pathways
QuickGOO95147
Ontology : AmiGOinactivation of MAPK activity  RNA binding  protein tyrosine phosphatase activity  protein binding  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBIinactivation of MAPK activity  RNA binding  protein tyrosine phosphatase activity  protein binding  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  
NDEx NetworkDUSP14
Atlas of Cancer Signalling NetworkDUSP14
Wikipedia pathwaysDUSP14
Orthology - Evolution
OrthoDB11072
GeneTree (enSembl)ENSG00000276023
Phylogenetic Trees/Animal Genes : TreeFamDUSP14
HOVERGENO95147
HOGENOMO95147
Homologs : HomoloGeneDUSP14
Homology/Alignments : Family Browser (UCSC)DUSP14
Gene fusions - Rearrangements
Fusion : MitelmanCOBL/DUSP14 [7p12.1/17q12]  [t(7;17)(p12;q12)]  
Fusion : MitelmanDUSP14/EME1 [17q12/17q21.33]  [t(17;17)(q12;q21)]  
Fusion : MitelmanNLK/DUSP14 [17q11.2/17q12]  [t(17;17)(q11;q12)]  
Fusion: TCGACOBL 7p12.1 DUSP14 17q12 LUAD
Fusion: TCGADUSP14 17q12 EME1 17q21.33 BRCA
Fusion: TCGANLK 17q11.2 DUSP14 17q12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP14
dbVarDUSP14
ClinVarDUSP14
1000_GenomesDUSP14 
Exome Variant ServerDUSP14
ExAC (Exome Aggregation Consortium)DUSP14 (select the gene name)
Genetic variants : HAPMAP11072
Genomic Variants (DGV)DUSP14 [DGVbeta]
DECIPHERDUSP14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP14 
Mutations
ICGC Data PortalDUSP14 
TCGA Data PortalDUSP14 
Broad Tumor PortalDUSP14
OASIS PortalDUSP14 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDUSP14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP14
DgiDB (Drug Gene Interaction Database)DUSP14
DoCM (Curated mutations)DUSP14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP14 (select a term)
intoGenDUSP14
Cancer3DDUSP14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606618   
Orphanet
MedgenDUSP14
Genetic Testing Registry DUSP14
NextProtO95147 [Medical]
TSGene11072
GENETestsDUSP14
Target ValidationDUSP14
Huge Navigator DUSP14 [HugePedia]
snp3D : Map Gene to Disease11072
BioCentury BCIQDUSP14
ClinGenDUSP14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11072
Chemical/Pharm GKB GenePA27523
Clinical trialDUSP14
Miscellaneous
canSAR (ICR)DUSP14 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP14
EVEXDUSP14
GoPubMedDUSP14
iHOPDUSP14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:59 CEST 2017

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