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DUSP14 (dual specificity phosphatase 14)

Identity

Alias (NCBI)MKP-L
MKP6
HGNC (Hugo) DUSP14
HGNC Alias symbMKP-L
MKP6
HGNC Alias nameMKP-1 like protein tyrosine phosphatase
LocusID (NCBI) 11072
Atlas_Id 40372
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 37489891 and ends at 37513498 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COBL (7p12.1) / DUSP14 (17q12)DUSP14 (17q12) / EME1 (17q21.33)NLK (17q11.2) / DUSP14 (17q12)
COBL 7p12.1 / DUSP14 17q12DUSP14 17q12 / EME1 17q21.33NLK 17q11.2 / DUSP14 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DUSP14   17007
Cards
Entrez_Gene (NCBI)DUSP14    dual specificity phosphatase 14
AliasesMKP-L; MKP6
GeneCards (Weizmann)DUSP14
Ensembl hg19 (Hinxton)ENSG00000276023 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000276023 [Gene_View]  ENSG00000276023 [Sequence]  chr17:37489891-37513498 [Contig_View]  DUSP14 [Vega]
ICGC DataPortalENSG00000276023
TCGA cBioPortalDUSP14
AceView (NCBI)DUSP14
Genatlas (Paris)DUSP14
SOURCE (Princeton)DUSP14
Genetics Home Reference (NIH)DUSP14
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP14  -     chr17:37489891-37513498 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP14  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathDUSP14 - 17q12 [CytoView hg19]  DUSP14 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000276023
Genome Data Viewer NCBIDUSP14 [Mapview hg19]  
OMIM606618   
Gene and transcription
Genbank (Entrez)AF038844 AF120032 AK027210 AK314894 BC000370
RefSeq transcript (Entrez)NM_007026
Consensus coding sequences : CCDS (NCBI)DUSP14
Gene ExpressionDUSP14 [ NCBI-GEO ]   DUSP14 [ EBI - ARRAY_EXPRESS ]   DUSP14 [ SEEK ]   DUSP14 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP14 [ Firebrowse - Broad ]
GenevisibleExpression of DUSP14 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11072
GTEX Portal (Tissue expression)DUSP14
Human Protein AtlasENSG00000276023-DUSP14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95147   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95147  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95147
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO95147
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Atypical_DUSP    Atypical_DUSP_subfamB    Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Domain families : Smart (EMBL)DSPc (SM00195)  
Conserved Domain (NCBI)DUSP14
PDB (RSDB)2WGP   
PDB Europe2WGP   
PDB (PDBSum)2WGP   
PDB (IMB)2WGP   
Structural Biology KnowledgeBase2WGP   
SCOP (Structural Classification of Proteins)2WGP   
CATH (Classification of proteins structures)2WGP   
SuperfamilyO95147
AlphaFold pdb e-kbO95147   
Human Protein Atlas [tissue]ENSG00000276023-DUSP14 [tissue]
HPRD09427
Protein Interaction databases
DIP (DOE-UCLA)O95147
IntAct (EBI)O95147
BioGRIDDUSP14
STRING (EMBL)DUSP14
ZODIACDUSP14
Ontologies - Pathways
QuickGOO95147
Ontology : AmiGOinactivation of MAPK activity  RNA binding  protein tyrosine phosphatase activity  protein binding  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  protein serine phosphatase activity  protein threonine phosphatase activity  
Ontology : EGO-EBIinactivation of MAPK activity  RNA binding  protein tyrosine phosphatase activity  protein binding  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  protein serine phosphatase activity  protein threonine phosphatase activity  
NDEx NetworkDUSP14
Atlas of Cancer Signalling NetworkDUSP14
Wikipedia pathwaysDUSP14
Orthology - Evolution
OrthoDB11072
GeneTree (enSembl)ENSG00000276023
Phylogenetic Trees/Animal Genes : TreeFamDUSP14
Homologs : HomoloGeneDUSP14
Homology/Alignments : Family Browser (UCSC)DUSP14
Gene fusions - Rearrangements
Fusion : MitelmanCOBL/DUSP14 [7p12.1/17q12]  
Fusion : MitelmanDUSP14/EME1 [17q12/17q21.33]  
Fusion : MitelmanNLK/DUSP14 [17q11.2/17q12]  
Fusion : QuiverDUSP14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP14
dbVarDUSP14
ClinVarDUSP14
MonarchDUSP14
1000_GenomesDUSP14 
Exome Variant ServerDUSP14
GNOMAD BrowserENSG00000276023
Varsome BrowserDUSP14
ACMGDUSP14 variants
VarityO95147
Genomic Variants (DGV)DUSP14 [DGVbeta]
DECIPHERDUSP14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP14 
Mutations
ICGC Data PortalDUSP14 
TCGA Data PortalDUSP14 
Broad Tumor PortalDUSP14
OASIS PortalDUSP14 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDUSP14
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDUSP14
DgiDB (Drug Gene Interaction Database)DUSP14
DoCM (Curated mutations)DUSP14
CIViC (Clinical Interpretations of Variants in Cancer)DUSP14
Cancer3DDUSP14
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606618   
Orphanet
DisGeNETDUSP14
MedgenDUSP14
Genetic Testing Registry DUSP14
NextProtO95147 [Medical]
GENETestsDUSP14
Target ValidationDUSP14
Huge Navigator DUSP14 [HugePedia]
ClinGenDUSP14
Clinical trials, drugs, therapy
MyCancerGenomeDUSP14
Protein Interactions : CTDDUSP14
Pharm GKB GenePA27523
PharosO95147
Clinical trialDUSP14
Miscellaneous
canSAR (ICR)DUSP14
HarmonizomeDUSP14
DataMed IndexDUSP14
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDUSP14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:26 CEST 2021

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