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DUSP2 (dual specificity phosphatase 2)

Identity

Alias_symbol (synonym)PAC-1
Other aliasPAC1
HGNC (Hugo) DUSP2
LocusID (NCBI) 1844
Atlas_Id 45939
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 96808908 and ends at 96811179 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DUSP2   3068
Cards
Entrez_Gene (NCBI)DUSP2  1844  dual specificity phosphatase 2
AliasesPAC-1; PAC1
GeneCards (Weizmann)DUSP2
Ensembl hg19 (Hinxton)ENSG00000158050 [Gene_View]  chr2:96808908-96811179 [Contig_View]  DUSP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000158050 [Gene_View]  chr2:96808908-96811179 [Contig_View]  DUSP2 [Vega]
ICGC DataPortalENSG00000158050
TCGA cBioPortalDUSP2
AceView (NCBI)DUSP2
Genatlas (Paris)DUSP2
WikiGenes1844
SOURCE (Princeton)DUSP2
Genetics Home Reference (NIH)DUSP2
Genomic and cartography
GoldenPath hg19 (UCSC)DUSP2  -     chr2:96808908-96811179 -  2q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DUSP2  -     2q11.2   [Description]    (hg38-Dec_2013)
EnsemblDUSP2 - 2q11.2 [CytoView hg19]  DUSP2 - 2q11.2 [CytoView hg38]
Mapping of homologs : NCBIDUSP2 [Mapview hg19]  DUSP2 [Mapview hg38]
OMIM603068   
Gene and transcription
Genbank (Entrez)AF331843 BC007771 DB475178 EU832639 EU832716
RefSeq transcript (Entrez)NM_004418
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929303
Consensus coding sequences : CCDS (NCBI)DUSP2
Cluster EST : UnigeneHs.1183 [ NCBI ]
CGAP (NCI)Hs.1183
Alternative Splicing GalleryENSG00000158050
Gene ExpressionDUSP2 [ NCBI-GEO ]   DUSP2 [ EBI - ARRAY_EXPRESS ]   DUSP2 [ SEEK ]   DUSP2 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1844
GTEX Portal (Tissue expression)DUSP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05923   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05923  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05923
Splice isoforms : SwissVarQ05923
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusQ05923
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    DUSP    MKP    Prot-tyrosine_phosphatase-like    Rhodanese-like_dom    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00782    pfam00581   
Domain families : Smart (EMBL)DSPc (SM00195)  RHOD (SM00450)  
Conserved Domain (NCBI)DUSP2
DMDM Disease mutations1844
Blocks (Seattle)DUSP2
PDB (SRS)1M3G   
PDB (PDBSum)1M3G   
PDB (IMB)1M3G   
PDB (RSDB)1M3G   
Structural Biology KnowledgeBase1M3G   
SCOP (Structural Classification of Proteins)1M3G   
CATH (Classification of proteins structures)1M3G   
SuperfamilyQ05923
Human Protein AtlasENSG00000158050
Peptide AtlasQ05923
HPRD04348
IPIIPI00016729   IPI00383173   
Protein Interaction databases
DIP (DOE-UCLA)Q05923
IntAct (EBI)Q05923
FunCoupENSG00000158050
BioGRIDDUSP2
STRING (EMBL)DUSP2
ZODIACDUSP2
Ontologies - Pathways
QuickGOQ05923
Ontology : AmiGOinactivation of MAPK activity  endoderm formation  protein tyrosine phosphatase activity  protein binding  nucleus  protein dephosphorylation  protein tyrosine/threonine phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  mitogen-activated protein kinase binding  
Ontology : EGO-EBIinactivation of MAPK activity  endoderm formation  protein tyrosine phosphatase activity  protein binding  nucleus  protein dephosphorylation  protein tyrosine/threonine phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  mitogen-activated protein kinase binding  
Pathways : BIOCARTARegulation of MAP Kinase Pathways Through Dual Specificity Phosphatases [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkDUSP2
Atlas of Cancer Signalling NetworkDUSP2
Wikipedia pathwaysDUSP2
Orthology - Evolution
OrthoDB1844
GeneTree (enSembl)ENSG00000158050
Phylogenetic Trees/Animal Genes : TreeFamDUSP2
HOVERGENQ05923
HOGENOMQ05923
Homologs : HomoloGeneDUSP2
Homology/Alignments : Family Browser (UCSC)DUSP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP2
dbVarDUSP2
ClinVarDUSP2
1000_GenomesDUSP2 
Exome Variant ServerDUSP2
ExAC (Exome Aggregation Consortium)DUSP2 (select the gene name)
Genetic variants : HAPMAP1844
Genomic Variants (DGV)DUSP2 [DGVbeta]
DECIPHER (Syndromes)2:96808908-96811179  ENSG00000158050
CONAN: Copy Number AnalysisDUSP2 
Mutations
ICGC Data PortalDUSP2 
TCGA Data PortalDUSP2 
Broad Tumor PortalDUSP2
OASIS PortalDUSP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDUSP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP2
DgiDB (Drug Gene Interaction Database)DUSP2
DoCM (Curated mutations)DUSP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP2 (select a term)
intoGenDUSP2
Cancer3DDUSP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603068   
Orphanet
MedgenDUSP2
Genetic Testing Registry DUSP2
NextProtQ05923 [Medical]
TSGene1844
GENETestsDUSP2
Huge Navigator DUSP2 [HugePedia]
snp3D : Map Gene to Disease1844
BioCentury BCIQDUSP2
ClinGenDUSP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1844
Chemical/Pharm GKB GenePA27525
Clinical trialDUSP2
Miscellaneous
canSAR (ICR)DUSP2 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP2
EVEXDUSP2
GoPubMedDUSP2
iHOPDUSP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:04:00 CET 2017

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