Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DUSP22 (dual specificity phosphatase 22)

Identity

Alias (NCBI)JKAP
JSP-1
JSP1
LMW-DSP2
LMWDSP2
MKP-x
MKPX
VHX
HGNC (Hugo) DUSP22
HGNC Alias symbMKPX
JSP1
JKAP
VHX
LocusID (NCBI) 56940
Atlas_Id 40373
Location 6p25.3  [Link to chromosome band 6p25]
Location_base_pair Starts at 292057 and ends at 351355 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP22 (6p25.3) / PTK7 (6p21.1)DUSP22 6p25.3 / PTK7 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]
  Anaplastic large cell lymphoma, ALK-negative
Breast implant-associated anaplastic large cell lymphoma
del(6p) (loss of JARID2 and DTNBP1) in myeloid malignances
Lymphomatoid papulosis (LyP) with 6p25.3 rearrangement DUSP22 and IRF4/
t(6;7)(p25.3;q32.3) DUSP22/FRA7H
t(2;6)(p12;p25) IRF4/IGK::t(6;14)(p25;q32) IRF4/IGH::t(6;22)(p25;q11) IRF4/IGL

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p25) DUSP22/PTK7

External links

Nomenclature
HGNC (Hugo)DUSP22   16077
Cards
Entrez_Gene (NCBI)DUSP22  56940  dual specificity phosphatase 22
AliasesJKAP; JSP-1; JSP1; LMW-DSP2; 
LMWDSP2; MKP-x; MKPX; VHX
GeneCards (Weizmann)DUSP22
Ensembl hg19 (Hinxton)ENSG00000112679 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112679 [Gene_View]  ENSG00000112679 [Sequence]  chr6:292057-351355 [Contig_View]  DUSP22 [Vega]
ICGC DataPortalENSG00000112679
TCGA cBioPortalDUSP22
AceView (NCBI)DUSP22
Genatlas (Paris)DUSP22
WikiGenes56940
SOURCE (Princeton)DUSP22
Genetics Home Reference (NIH)DUSP22
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP22  -     chr6:292057-351355 +  6p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP22  -     6p25.3   [Description]    (hg19-Feb_2009)
GoldenPathDUSP22 - 6p25.3 [CytoView hg19]  DUSP22 - 6p25.3 [CytoView hg38]
ImmunoBaseENSG00000112679
genome Data Viewer NCBIDUSP22 [Mapview hg19]  
OMIM616778   
Gene and transcription
Genbank (Entrez)AB208997 AF165519 AF424702 AK000383 AK074410
RefSeq transcript (Entrez)NM_001286555 NM_020185
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUSP22
Alternative Splicing GalleryENSG00000112679
Gene ExpressionDUSP22 [ NCBI-GEO ]   DUSP22 [ EBI - ARRAY_EXPRESS ]   DUSP22 [ SEEK ]   DUSP22 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP22 [ Firebrowse - Broad ]
GenevisibleExpression of DUSP22 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56940
GTEX Portal (Tissue expression)DUSP22
Human Protein AtlasENSG00000112679-DUSP22 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRW4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRW4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRW4
Splice isoforms : SwissVarQ9NRW4
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NRW4
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Atypical_DUSP    Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Domain families : Smart (EMBL)DSPc (SM00195)  
Conserved Domain (NCBI)DUSP22
DMDM Disease mutations56940
Blocks (Seattle)DUSP22
PDB (RSDB)1WRM    4WOH   
PDB Europe1WRM    4WOH   
PDB (PDBSum)1WRM    4WOH   
PDB (IMB)1WRM    4WOH   
Structural Biology KnowledgeBase1WRM    4WOH   
SCOP (Structural Classification of Proteins)1WRM    4WOH   
CATH (Classification of proteins structures)1WRM    4WOH   
SuperfamilyQ9NRW4
Human Protein Atlas [tissue]ENSG00000112679-DUSP22 [tissue]
Peptide AtlasQ9NRW4
HPRD13255
IPIIPI00024617   IPI00646309   IPI01010403   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRW4
IntAct (EBI)Q9NRW4
FunCoupENSG00000112679
BioGRIDDUSP22
STRING (EMBL)DUSP22
ZODIACDUSP22
Ontologies - Pathways
QuickGOQ9NRW4
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of T cell mediated immunity  protein tyrosine phosphatase activity  non-membrane spanning protein tyrosine phosphatase activity  nucleus  cytoplasm  cytosol  plasma membrane  transforming growth factor beta receptor signaling pathway  protein tyrosine/serine/threonine phosphatase activity  negative regulation of cell migration  filamentous actin  peptidyl-tyrosine dephosphorylation  regulation of cell proliferation  positive regulation of JNK cascade  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  negative regulation of focal adhesion assembly  leading edge of lamellipodium  cellular response to epidermal growth factor stimulus  negative regulation of non-membrane spanning protein tyrosine kinase activity  protein tyrosine kinase binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of T cell mediated immunity  protein tyrosine phosphatase activity  non-membrane spanning protein tyrosine phosphatase activity  nucleus  cytoplasm  cytosol  plasma membrane  transforming growth factor beta receptor signaling pathway  protein tyrosine/serine/threonine phosphatase activity  negative regulation of cell migration  filamentous actin  peptidyl-tyrosine dephosphorylation  regulation of cell proliferation  positive regulation of JNK cascade  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  negative regulation of focal adhesion assembly  leading edge of lamellipodium  cellular response to epidermal growth factor stimulus  negative regulation of non-membrane spanning protein tyrosine kinase activity  protein tyrosine kinase binding  
NDEx NetworkDUSP22
Atlas of Cancer Signalling NetworkDUSP22
Wikipedia pathwaysDUSP22
Orthology - Evolution
OrthoDB56940
GeneTree (enSembl)ENSG00000112679
Phylogenetic Trees/Animal Genes : TreeFamDUSP22
HOGENOMQ9NRW4
Homologs : HomoloGeneDUSP22
Homology/Alignments : Family Browser (UCSC)DUSP22
Gene fusions - Rearrangements
Fusion : MitelmanDUSP22/PTK7 [6p25.3/6p21.1]  
Fusion PortalDUSP22 6p25.3 PTK7 6p21.1 PRAD
Fusion : QuiverDUSP22
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP22
dbVarDUSP22
ClinVarDUSP22
MonarchDUSP22
1000_GenomesDUSP22 
Exome Variant ServerDUSP22
GNOMAD BrowserENSG00000112679
Varsome BrowserDUSP22
Genetic variants : HAPMAP56940
Genomic Variants (DGV)DUSP22 [DGVbeta]
DECIPHERDUSP22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP22 
Mutations
ICGC Data PortalDUSP22 
TCGA Data PortalDUSP22 
Broad Tumor PortalDUSP22
OASIS PortalDUSP22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP22  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDUSP22
Mutations and Diseases : HGMDDUSP22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP22
DgiDB (Drug Gene Interaction Database)DUSP22
DoCM (Curated mutations)DUSP22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP22 (select a term)
intoGenDUSP22
Cancer3DDUSP22(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616778   
Orphanet
DisGeNETDUSP22
MedgenDUSP22
Genetic Testing Registry DUSP22
NextProtQ9NRW4 [Medical]
TSGene56940
GENETestsDUSP22
Target ValidationDUSP22
Huge Navigator DUSP22 [HugePedia]
snp3D : Map Gene to Disease56940
BioCentury BCIQDUSP22
ClinGenDUSP22
Clinical trials, drugs, therapy
Protein Interactions : CTD56940
Pharm GKB GenePA134991025
Clinical trialDUSP22
Miscellaneous
canSAR (ICR)DUSP22 (select the gene name)
HarmonizomeDUSP22
DataMed IndexDUSP22
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP22
EVEXDUSP22
GoPubMedDUSP22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:09:28 CEST 2020
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