Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DUSP3 (dual specificity phosphatase 3)

Identity

Alias_namesVHR
vaccinia virus phosphatase VH1-related
Other alias
HGNC (Hugo) DUSP3
LocusID (NCBI) 1845
Atlas_Id 40374
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 43766121 and ends at 43779000 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DUSP3 (17q21.31) / PABPC4 (1p34.3)SYN1 (Xp11.23) / DUSP3 (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DUSP3   3069
Cards
Entrez_Gene (NCBI)DUSP3  1845  dual specificity phosphatase 3
AliasesVHR
GeneCards (Weizmann)DUSP3
Ensembl hg19 (Hinxton)ENSG00000108861 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108861 [Gene_View]  chr17:43766121-43779000 [Contig_View]  DUSP3 [Vega]
ICGC DataPortalENSG00000108861
TCGA cBioPortalDUSP3
AceView (NCBI)DUSP3
Genatlas (Paris)DUSP3
WikiGenes1845
SOURCE (Princeton)DUSP3
Genetics Home Reference (NIH)DUSP3
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP3  -     chr17:43766121-43779000 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP3  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblDUSP3 - 17q21.31 [CytoView hg19]  DUSP3 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIDUSP3 [Mapview hg19]  DUSP3 [Mapview hg38]
OMIM600183   
Gene and transcription
Genbank (Entrez)AB451424 AK055834 AK129822 AK226170 AL049417
RefSeq transcript (Entrez)NM_004090
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUSP3
Cluster EST : UnigeneHs.181046 [ NCBI ]
CGAP (NCI)Hs.181046
Alternative Splicing GalleryENSG00000108861
Gene ExpressionDUSP3 [ NCBI-GEO ]   DUSP3 [ EBI - ARRAY_EXPRESS ]   DUSP3 [ SEEK ]   DUSP3 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1845
GTEX Portal (Tissue expression)DUSP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51452   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51452  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51452
Splice isoforms : SwissVarP51452
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP51452
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Atypical_DUSP    Atypical_DUSP_famA    Dual-sp_phosphatase_cat-dom    DUSP    Prot-tyrosine_phosphatase-like    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Domain families : Smart (EMBL)DSPc (SM00195)  
Conserved Domain (NCBI)DUSP3
DMDM Disease mutations1845
Blocks (Seattle)DUSP3
PDB (SRS)1J4X    1VHR    3F81   
PDB (PDBSum)1J4X    1VHR    3F81   
PDB (IMB)1J4X    1VHR    3F81   
PDB (RSDB)1J4X    1VHR    3F81   
Structural Biology KnowledgeBase1J4X    1VHR    3F81   
SCOP (Structural Classification of Proteins)1J4X    1VHR    3F81   
CATH (Classification of proteins structures)1J4X    1VHR    3F81   
SuperfamilyP51452
Human Protein AtlasENSG00000108861
Peptide AtlasP51452
HPRD02553
IPIIPI00018671   IPI00796237   IPI00980124   
Protein Interaction databases
DIP (DOE-UCLA)P51452
IntAct (EBI)P51452
FunCoupENSG00000108861
BioGRIDDUSP3
STRING (EMBL)DUSP3
ZODIACDUSP3
Ontologies - Pathways
QuickGOP51452
Ontology : AmiGOinactivation of MAPK activity  in utero embryonic development  immunological synapse  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  nucleus  nucleoplasm  nucleoplasm  cytosol  protein tyrosine/serine/threonine phosphatase activity  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  protein kinase binding  MAP kinase phosphatase activity  peptidyl-tyrosine dephosphorylation  negative regulation of MAPK cascade  positive regulation of mitotic cell cycle  negative regulation of JNK cascade  negative regulation of JNK cascade  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  extracellular exosome  negative regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIinactivation of MAPK activity  in utero embryonic development  immunological synapse  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  nucleus  nucleoplasm  nucleoplasm  cytosol  protein tyrosine/serine/threonine phosphatase activity  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  protein kinase binding  MAP kinase phosphatase activity  peptidyl-tyrosine dephosphorylation  negative regulation of MAPK cascade  positive regulation of mitotic cell cycle  negative regulation of JNK cascade  negative regulation of JNK cascade  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  extracellular exosome  negative regulation of ERK1 and ERK2 cascade  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkDUSP3
Atlas of Cancer Signalling NetworkDUSP3
Wikipedia pathwaysDUSP3
Orthology - Evolution
OrthoDB1845
GeneTree (enSembl)ENSG00000108861
Phylogenetic Trees/Animal Genes : TreeFamDUSP3
HOVERGENP51452
HOGENOMP51452
Homologs : HomoloGeneDUSP3
Homology/Alignments : Family Browser (UCSC)DUSP3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP3
dbVarDUSP3
ClinVarDUSP3
1000_GenomesDUSP3 
Exome Variant ServerDUSP3
ExAC (Exome Aggregation Consortium)DUSP3 (select the gene name)
Genetic variants : HAPMAP1845
Genomic Variants (DGV)DUSP3 [DGVbeta]
DECIPHERDUSP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP3 
Mutations
ICGC Data PortalDUSP3 
TCGA Data PortalDUSP3 
Broad Tumor PortalDUSP3
OASIS PortalDUSP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDUSP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP3
DgiDB (Drug Gene Interaction Database)DUSP3
DoCM (Curated mutations)DUSP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP3 (select a term)
intoGenDUSP3
Cancer3DDUSP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600183   
Orphanet
MedgenDUSP3
Genetic Testing Registry DUSP3
NextProtP51452 [Medical]
TSGene1845
GENETestsDUSP3
Target ValidationDUSP3
Huge Navigator DUSP3 [HugePedia]
snp3D : Map Gene to Disease1845
BioCentury BCIQDUSP3
ClinGenDUSP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1845
Chemical/Pharm GKB GenePA27526
Clinical trialDUSP3
Miscellaneous
canSAR (ICR)DUSP3 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP3
EVEXDUSP3
GoPubMedDUSP3
iHOPDUSP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:00:00 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.