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DUSP3 (dual specificity phosphatase 3)

Identity

Alias (NCBI)VHR
HGNC (Hugo) DUSP3
HGNC Previous nameVHR
HGNC Previous namevaccinia virus phosphatase VH1-related
LocusID (NCBI) 1845
Atlas_Id 40374
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 43766126 and ends at 43778977 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP3 (17q21.31)::PABPC4 (1p34.3)SYN1 (Xp11.23)::DUSP3 (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DUSP3   3069
Cards
Entrez_Gene (NCBI)DUSP3    dual specificity phosphatase 3
AliasesVHR
GeneCards (Weizmann)DUSP3
Ensembl hg19 (Hinxton)ENSG00000108861 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108861 [Gene_View]  ENSG00000108861 [Sequence]  chr17:43766126-43778977 [Contig_View]  DUSP3 [Vega]
ICGC DataPortalENSG00000108861
TCGA cBioPortalDUSP3
AceView (NCBI)DUSP3
Genatlas (Paris)DUSP3
SOURCE (Princeton)DUSP3
Genetics Home Reference (NIH)DUSP3
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP3  -     chr17:43766126-43778977 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP3  -     17q21.31   [Description]    (hg19-Feb_2009)
GoldenPathDUSP3 - 17q21.31 [CytoView hg19]  DUSP3 - 17q21.31 [CytoView hg38]
ImmunoBaseENSG00000108861
Genome Data Viewer NCBIDUSP3 [Mapview hg19]  
OMIM600183   
Gene and transcription
Genbank (Entrez)AB451424 AK055834 AK129822 AK226170 AL049417
RefSeq transcript (Entrez)NM_004090
Consensus coding sequences : CCDS (NCBI)DUSP3
Gene ExpressionDUSP3 [ NCBI-GEO ]   DUSP3 [ EBI - ARRAY_EXPRESS ]   DUSP3 [ SEEK ]   DUSP3 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP3 [ Firebrowse - Broad ]
GenevisibleExpression of DUSP3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1845
GTEX Portal (Tissue expression)DUSP3
Human Protein AtlasENSG00000108861-DUSP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51452   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51452  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51452
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP51452
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Atypical_DUSP    Atypical_DUSP_subfamA    Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)   
Domain families : Pfam (NCBI)pfam00782   
Domain families : Smart (EMBL)DSPc (SM00195)  
Conserved Domain (NCBI)DUSP3
PDB (RSDB)1J4X    1VHR    3F81   
PDB Europe1J4X    1VHR    3F81   
PDB (PDBSum)1J4X    1VHR    3F81   
PDB (IMB)1J4X    1VHR    3F81   
Structural Biology KnowledgeBase1J4X    1VHR    3F81   
SCOP (Structural Classification of Proteins)1J4X    1VHR    3F81   
CATH (Classification of proteins structures)1J4X    1VHR    3F81   
SuperfamilyP51452
AlphaFold pdb e-kbP51452   
Human Protein Atlas [tissue]ENSG00000108861-DUSP3 [tissue]
HPRD02553
Protein Interaction databases
DIP (DOE-UCLA)P51452
IntAct (EBI)P51452
BioGRIDDUSP3
STRING (EMBL)DUSP3
ZODIACDUSP3
Ontologies - Pathways
QuickGOP51452
Ontology : AmiGOinactivation of MAPK activity  immunological synapse  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  cytosol  cytoskeletal protein binding  protein tyrosine/serine/threonine phosphatase activity  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  protein kinase binding  negative regulation of cell migration  receptor tyrosine kinase binding  MAP kinase phosphatase activity  MAP kinase phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  negative regulation of epidermal growth factor receptor signaling pathway  negative regulation of MAPK cascade  positive regulation of mitotic cell cycle  positive regulation of mitotic cell cycle  negative regulation of JNK cascade  negative regulation of JNK cascade  negative regulation of JNK cascade  negative regulation of T cell receptor signaling pathway  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  negative regulation of T cell activation  negative regulation of chemotaxis  regulation of focal adhesion assembly  negative regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  cellular response to epidermal growth factor stimulus  protein serine phosphatase activity  protein threonine phosphatase activity  positive regulation of focal adhesion disassembly  peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity  protein tyrosine kinase binding  
Ontology : EGO-EBIinactivation of MAPK activity  immunological synapse  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  cytosol  cytoskeletal protein binding  protein tyrosine/serine/threonine phosphatase activity  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  protein kinase binding  negative regulation of cell migration  receptor tyrosine kinase binding  MAP kinase phosphatase activity  MAP kinase phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  negative regulation of epidermal growth factor receptor signaling pathway  negative regulation of MAPK cascade  positive regulation of mitotic cell cycle  positive regulation of mitotic cell cycle  negative regulation of JNK cascade  negative regulation of JNK cascade  negative regulation of JNK cascade  negative regulation of T cell receptor signaling pathway  negative regulation of T cell receptor signaling pathway  negative regulation of T cell activation  negative regulation of T cell activation  negative regulation of chemotaxis  regulation of focal adhesion assembly  negative regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  cellular response to epidermal growth factor stimulus  protein serine phosphatase activity  protein threonine phosphatase activity  positive regulation of focal adhesion disassembly  peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity  protein tyrosine kinase binding  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkDUSP3
Atlas of Cancer Signalling NetworkDUSP3
Wikipedia pathwaysDUSP3
Orthology - Evolution
OrthoDB1845
GeneTree (enSembl)ENSG00000108861
Phylogenetic Trees/Animal Genes : TreeFamDUSP3
Homologs : HomoloGeneDUSP3
Homology/Alignments : Family Browser (UCSC)DUSP3
Gene fusions - Rearrangements
Fusion : QuiverDUSP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP3
dbVarDUSP3
ClinVarDUSP3
MonarchDUSP3
1000_GenomesDUSP3 
Exome Variant ServerDUSP3
GNOMAD BrowserENSG00000108861
Varsome BrowserDUSP3
ACMGDUSP3 variants
VarityP51452
Genomic Variants (DGV)DUSP3 [DGVbeta]
DECIPHERDUSP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP3 
Mutations
ICGC Data PortalDUSP3 
TCGA Data PortalDUSP3 
Broad Tumor PortalDUSP3
OASIS PortalDUSP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDUSP3
Mutations and Diseases : HGMDDUSP3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDUSP3
DgiDB (Drug Gene Interaction Database)DUSP3
DoCM (Curated mutations)DUSP3
CIViC (Clinical Interpretations of Variants in Cancer)DUSP3
Cancer3DDUSP3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600183   
Orphanet
DisGeNETDUSP3
MedgenDUSP3
Genetic Testing Registry DUSP3
NextProtP51452 [Medical]
GENETestsDUSP3
Target ValidationDUSP3
Huge Navigator DUSP3 [HugePedia]
ClinGenDUSP3
Clinical trials, drugs, therapy
MyCancerGenomeDUSP3
Protein Interactions : CTDDUSP3
Pharm GKB GenePA27526
PharosP51452
Clinical trialDUSP3
Miscellaneous
canSAR (ICR)DUSP3
HarmonizomeDUSP3
ARCHS4DUSP3
DataMed IndexDUSP3
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDUSP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jan 17 15:22:35 CET 2022

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