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DUSP5 (dual specificity phosphatase 5)

Identity

Alias_symbol (synonym)HVH3
Other aliasDUSP
HGNC (Hugo) DUSP5
LocusID (NCBI) 1847
Atlas_Id 40376
Location 10q25.2  [Link to chromosome band 10q25]
Location_base_pair Starts at 110497867 and ends at 110511544 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DUSP5 (10q25.2) / PPP1R16A (8q24.3)DUSP5 (10q25.2) / RAP2B (3q25.2)DUSP5 (10q25.2) / S100A6 (1q21.3)
PLIN3 (19p13.3) / DUSP5 (10q25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DUSP5   3071
Cards
Entrez_Gene (NCBI)DUSP5  1847  dual specificity phosphatase 5
AliasesDUSP; HVH3
GeneCards (Weizmann)DUSP5
Ensembl hg19 (Hinxton)ENSG00000138166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138166 [Gene_View]  chr10:110497867-110511544 [Contig_View]  DUSP5 [Vega]
ICGC DataPortalENSG00000138166
TCGA cBioPortalDUSP5
AceView (NCBI)DUSP5
Genatlas (Paris)DUSP5
WikiGenes1847
SOURCE (Princeton)DUSP5
Genetics Home Reference (NIH)DUSP5
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP5  -     chr10:110497867-110511544 +  10q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP5  -     10q25.2   [Description]    (hg19-Feb_2009)
EnsemblDUSP5 - 10q25.2 [CytoView hg19]  DUSP5 - 10q25.2 [CytoView hg38]
Mapping of homologs : NCBIDUSP5 [Mapview hg19]  DUSP5 [Mapview hg38]
OMIM603069   
Gene and transcription
Genbank (Entrez)AB209823 BC062545 BF979291 BI495660 CB991409
RefSeq transcript (Entrez)NM_004419
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUSP5
Cluster EST : UnigeneHs.2128 [ NCBI ]
CGAP (NCI)Hs.2128
Alternative Splicing GalleryENSG00000138166
Gene ExpressionDUSP5 [ NCBI-GEO ]   DUSP5 [ EBI - ARRAY_EXPRESS ]   DUSP5 [ SEEK ]   DUSP5 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1847
GTEX Portal (Tissue expression)DUSP5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16690   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16690  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16690
Splice isoforms : SwissVarQ16690
PhosPhoSitePlusQ16690
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    DUSP    MKP    Prot-tyrosine_phosphatase-like    Rhodanese-like_dom    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00782    pfam00581   
Domain families : Smart (EMBL)DSPc (SM00195)  PTPc_motif (SM00404)  RHOD (SM00450)  
Conserved Domain (NCBI)DUSP5
DMDM Disease mutations1847
Blocks (Seattle)DUSP5
PDB (SRS)2G6Z   
PDB (PDBSum)2G6Z   
PDB (IMB)2G6Z   
PDB (RSDB)2G6Z   
Structural Biology KnowledgeBase2G6Z   
SCOP (Structural Classification of Proteins)2G6Z   
CATH (Classification of proteins structures)2G6Z   
SuperfamilyQ16690
Human Protein AtlasENSG00000138166
Peptide AtlasQ16690
HPRD04349
IPIIPI00003478   
Protein Interaction databases
DIP (DOE-UCLA)Q16690
IntAct (EBI)Q16690
FunCoupENSG00000138166
BioGRIDDUSP5
STRING (EMBL)DUSP5
ZODIACDUSP5
Ontologies - Pathways
QuickGOQ16690
Ontology : AmiGOMAPK cascade  activation of MAPK activity  inactivation of MAPK activity  endoderm formation  protein tyrosine phosphatase activity  protein binding  nucleoplasm  protein dephosphorylation  protein tyrosine/serine/threonine phosphatase activity  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-threonine dephosphorylation  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  inactivation of MAPK activity  endoderm formation  protein tyrosine phosphatase activity  protein binding  nucleoplasm  protein dephosphorylation  protein tyrosine/serine/threonine phosphatase activity  protein tyrosine/serine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  peptidyl-threonine dephosphorylation  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkDUSP5
Atlas of Cancer Signalling NetworkDUSP5
Wikipedia pathwaysDUSP5
Orthology - Evolution
OrthoDB1847
GeneTree (enSembl)ENSG00000138166
Phylogenetic Trees/Animal Genes : TreeFamDUSP5
HOVERGENQ16690
HOGENOMQ16690
Homologs : HomoloGeneDUSP5
Homology/Alignments : Family Browser (UCSC)DUSP5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP5
dbVarDUSP5
ClinVarDUSP5
1000_GenomesDUSP5 
Exome Variant ServerDUSP5
ExAC (Exome Aggregation Consortium)DUSP5 (select the gene name)
Genetic variants : HAPMAP1847
Genomic Variants (DGV)DUSP5 [DGVbeta]
DECIPHERDUSP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP5 
Mutations
ICGC Data PortalDUSP5 
TCGA Data PortalDUSP5 
Broad Tumor PortalDUSP5
OASIS PortalDUSP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDUSP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP5
DgiDB (Drug Gene Interaction Database)DUSP5
DoCM (Curated mutations)DUSP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP5 (select a term)
intoGenDUSP5
Cancer3DDUSP5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603069   
Orphanet
MedgenDUSP5
Genetic Testing Registry DUSP5
NextProtQ16690 [Medical]
TSGene1847
GENETestsDUSP5
Huge Navigator DUSP5 [HugePedia]
snp3D : Map Gene to Disease1847
BioCentury BCIQDUSP5
ClinGenDUSP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1847
Chemical/Pharm GKB GenePA27528
Clinical trialDUSP5
Miscellaneous
canSAR (ICR)DUSP5 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP5
EVEXDUSP5
GoPubMedDUSP5
iHOPDUSP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:14:01 CEST 2017

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