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DUSP7 (dual specificity phosphatase 7)

Identity

Alias_symbol (synonym)MKP-X
PYST2
Other aliasMKPX
HGNC (Hugo) DUSP7
LocusID (NCBI) 1849
Atlas_Id 40377
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 52048921 and ends at 52056445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP7 (3p21.2) / PBRM1 (3p21.1)DUSP7 3p21.2 / PBRM1 3p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DUSP7   3073
Cards
Entrez_Gene (NCBI)DUSP7  1849  dual specificity phosphatase 7
AliasesMKPX; PYST2
GeneCards (Weizmann)DUSP7
Ensembl hg19 (Hinxton)ENSG00000164086 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164086 [Gene_View]  chr3:52048921-52056445 [Contig_View]  DUSP7 [Vega]
ICGC DataPortalENSG00000164086
TCGA cBioPortalDUSP7
AceView (NCBI)DUSP7
Genatlas (Paris)DUSP7
WikiGenes1849
SOURCE (Princeton)DUSP7
Genetics Home Reference (NIH)DUSP7
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP7  -     chr3:52048921-52056445 -  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP7  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblDUSP7 - 3p21.2 [CytoView hg19]  DUSP7 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIDUSP7 [Mapview hg19]  DUSP7 [Mapview hg38]
OMIM602749   
Gene and transcription
Genbank (Entrez)AF508727 AF508728 AL110157 BC019107 BC104880
RefSeq transcript (Entrez)NM_001947
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DUSP7
Cluster EST : UnigeneHs.591664 [ NCBI ]
CGAP (NCI)Hs.591664
Alternative Splicing GalleryENSG00000164086
Gene ExpressionDUSP7 [ NCBI-GEO ]   DUSP7 [ EBI - ARRAY_EXPRESS ]   DUSP7 [ SEEK ]   DUSP7 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1849
GTEX Portal (Tissue expression)DUSP7
Human Protein AtlasENSG00000164086-DUSP7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16829   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16829  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16829
Splice isoforms : SwissVarQ16829
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusQ16829
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    DUSP    MKP    Prot-tyrosine_phosphatase-like    Rhodanese-like_dom    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00782    pfam00581   
Domain families : Smart (EMBL)DSPc (SM00195)  RHOD (SM00450)  
Conserved Domain (NCBI)DUSP7
DMDM Disease mutations1849
Blocks (Seattle)DUSP7
PDB (SRS)4Y2E   
PDB (PDBSum)4Y2E   
PDB (IMB)4Y2E   
PDB (RSDB)4Y2E   
Structural Biology KnowledgeBase4Y2E   
SCOP (Structural Classification of Proteins)4Y2E   
CATH (Classification of proteins structures)4Y2E   
SuperfamilyQ16829
Human Protein Atlas [tissue]ENSG00000164086-DUSP7 [tissue]
Peptide AtlasQ16829
HPRD04125
IPIIPI00394738   IPI00944963   IPI00945121   
Protein Interaction databases
DIP (DOE-UCLA)Q16829
IntAct (EBI)Q16829
FunCoupENSG00000164086
BioGRIDDUSP7
STRING (EMBL)DUSP7
ZODIACDUSP7
Ontologies - Pathways
QuickGOQ16829
Ontology : AmiGOMAPK cascade  activation of MAPK activity  inactivation of MAPK activity  protein tyrosine phosphatase activity  protein binding  nucleoplasm  cytosol  cytosol  protein tyrosine/serine/threonine phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  negative regulation of MAP kinase activity  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  inactivation of MAPK activity  protein tyrosine phosphatase activity  protein binding  nucleoplasm  cytosol  cytosol  protein tyrosine/serine/threonine phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  negative regulation of MAP kinase activity  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkDUSP7
Atlas of Cancer Signalling NetworkDUSP7
Wikipedia pathwaysDUSP7
Orthology - Evolution
OrthoDB1849
GeneTree (enSembl)ENSG00000164086
Phylogenetic Trees/Animal Genes : TreeFamDUSP7
HOVERGENQ16829
HOGENOMQ16829
Homologs : HomoloGeneDUSP7
Homology/Alignments : Family Browser (UCSC)DUSP7
Gene fusions - Rearrangements
Fusion : MitelmanDUSP7/PBRM1 [3p21.2/3p21.1]  
Fusion: TCGA_MDACCDUSP7 3p21.2 PBRM1 3p21.1 BRCA
Tumor Fusion PortalDUSP7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP7
dbVarDUSP7
ClinVarDUSP7
1000_GenomesDUSP7 
Exome Variant ServerDUSP7
ExAC (Exome Aggregation Consortium)ENSG00000164086
GNOMAD BrowserENSG00000164086
Genetic variants : HAPMAP1849
Genomic Variants (DGV)DUSP7 [DGVbeta]
DECIPHERDUSP7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP7 
Mutations
ICGC Data PortalDUSP7 
TCGA Data PortalDUSP7 
Broad Tumor PortalDUSP7
OASIS PortalDUSP7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDUSP7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DUSP7
DgiDB (Drug Gene Interaction Database)DUSP7
DoCM (Curated mutations)DUSP7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DUSP7 (select a term)
intoGenDUSP7
Cancer3DDUSP7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602749   
Orphanet
DisGeNETDUSP7
MedgenDUSP7
Genetic Testing Registry DUSP7
NextProtQ16829 [Medical]
TSGene1849
GENETestsDUSP7
Target ValidationDUSP7
Huge Navigator DUSP7 [HugePedia]
snp3D : Map Gene to Disease1849
BioCentury BCIQDUSP7
ClinGenDUSP7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1849
Chemical/Pharm GKB GenePA27530
Clinical trialDUSP7
Miscellaneous
canSAR (ICR)DUSP7 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDUSP7
EVEXDUSP7
GoPubMedDUSP7
iHOPDUSP7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:11:21 CET 2017

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