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DUSP8 (dual specificity phosphatase 8)

Identity

Alias (NCBI)C11orf81
HB5
HVH-5
HVH8
HGNC (Hugo) DUSP8
HGNC Alias symbHVH-5
HB5
FLJ42958
HGNC Alias nameserine/threonine specific protein phosphatase
 H1 phosphatase, vaccinia virus homolog
HGNC Previous nameC11orf81
HGNC Previous namechromosome 11 open reading frame 81
LocusID (NCBI) 1850
Atlas_Id 40378
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1554051 and ends at 1572271 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP8 (11p15.5)::MYEOV (11q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DUSP8   3074
Cards
Entrez_Gene (NCBI)DUSP8    dual specificity phosphatase 8
AliasesC11orf81; HB5; HVH-5; HVH8
GeneCards (Weizmann)DUSP8
Ensembl hg19 (Hinxton)ENSG00000184545 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184545 [Gene_View]  ENSG00000184545 [Sequence]  chr11:1554051-1572271 [Contig_View]  DUSP8 [Vega]
ICGC DataPortalENSG00000184545
TCGA cBioPortalDUSP8
AceView (NCBI)DUSP8
Genatlas (Paris)DUSP8
SOURCE (Princeton)DUSP8
Genetics Home Reference (NIH)DUSP8
Genomic and cartography
GoldenPath hg38 (UCSC)DUSP8  -     chr11:1554051-1572271 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUSP8  -     11p15.5   [Description]    (hg19-Feb_2009)
GoldenPathDUSP8 - 11p15.5 [CytoView hg19]  DUSP8 - 11p15.5 [CytoView hg38]
ImmunoBaseENSG00000184545
Genome Data Viewer NCBIDUSP8 [Mapview hg19]  
OMIM602038   
Gene and transcription
Genbank (Entrez)AK124467 AK124948 BC038231 BC045110 BU740880
RefSeq transcript (Entrez)NM_004420
Consensus coding sequences : CCDS (NCBI)DUSP8
Gene ExpressionDUSP8 [ NCBI-GEO ]   DUSP8 [ EBI - ARRAY_EXPRESS ]   DUSP8 [ SEEK ]   DUSP8 [ MEM ]
Gene Expression Viewer (FireBrowse)DUSP8 [ Firebrowse - Broad ]
GenevisibleExpression of DUSP8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1850
GTEX Portal (Tissue expression)DUSP8
Human Protein AtlasENSG00000184545-DUSP8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13202   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13202  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13202
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ13202
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_DUAL (PS50054)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    MKP    Prot-tyrosine_phosphatase-like    Rhodanese-like_dom    Rhodanese-like_dom_sf    Tyr_Pase_AS    TYR_PHOSPHATASE_dom    TYR_PHOSPHATASE_DUAL_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00782    pfam00581   
Domain families : Smart (EMBL)DSPc (SM00195)  RHOD (SM00450)  
Conserved Domain (NCBI)DUSP8
PDB (RSDB)4JMK   
PDB Europe4JMK   
PDB (PDBSum)4JMK   
PDB (IMB)4JMK   
Structural Biology KnowledgeBase4JMK   
SCOP (Structural Classification of Proteins)4JMK   
CATH (Classification of proteins structures)4JMK   
SuperfamilyQ13202
AlphaFold pdb e-kbQ13202   
Human Protein Atlas [tissue]ENSG00000184545-DUSP8 [tissue]
HPRD03617
Protein Interaction databases
DIP (DOE-UCLA)Q13202
IntAct (EBI)Q13202
BioGRIDDUSP8
STRING (EMBL)DUSP8
ZODIACDUSP8
Ontologies - Pathways
QuickGOQ13202
Ontology : AmiGOphosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein tyrosine phosphatase activity  nucleus  cytoplasm  cytosol  protein tyrosine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  negative regulation of MAPK cascade  
Ontology : EGO-EBIphosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein tyrosine phosphatase activity  nucleus  cytoplasm  cytosol  protein tyrosine/threonine phosphatase activity  dephosphorylation  phosphatase activity  MAP kinase tyrosine/serine/threonine phosphatase activity  peptidyl-tyrosine dephosphorylation  negative regulation of MAPK cascade  
Pathways : BIOCARTABIOCARTA_DSPPATHWAY   
Pathways : KEGGKEGG_MAPK_SIGNALING   
NDEx NetworkDUSP8
Atlas of Cancer Signalling NetworkDUSP8
Wikipedia pathwaysDUSP8
Orthology - Evolution
OrthoDB1850
GeneTree (enSembl)ENSG00000184545
Phylogenetic Trees/Animal Genes : TreeFamDUSP8
Homologs : HomoloGeneDUSP8
Homology/Alignments : Family Browser (UCSC)DUSP8
Gene fusions - Rearrangements
Fusion : QuiverDUSP8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUSP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUSP8
dbVarDUSP8
ClinVarDUSP8
MonarchDUSP8
1000_GenomesDUSP8 
Exome Variant ServerDUSP8
GNOMAD BrowserENSG00000184545
Varsome BrowserDUSP8
ACMGDUSP8 variants
VarityQ13202
Genomic Variants (DGV)DUSP8 [DGVbeta]
DECIPHERDUSP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUSP8 
Mutations
ICGC Data PortalDUSP8 
TCGA Data PortalDUSP8 
Broad Tumor PortalDUSP8
OASIS PortalDUSP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDUSP8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDUSP8
Mutations and Diseases : HGMDDUSP8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDUSP8
DgiDB (Drug Gene Interaction Database)DUSP8
DoCM (Curated mutations)DUSP8
CIViC (Clinical Interpretations of Variants in Cancer)DUSP8
Cancer3DDUSP8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602038   
Orphanet
DisGeNETDUSP8
MedgenDUSP8
Genetic Testing Registry DUSP8
NextProtQ13202 [Medical]
GENETestsDUSP8
Target ValidationDUSP8
Huge Navigator DUSP8 [HugePedia]
ClinGenDUSP8
Clinical trials, drugs, therapy
MyCancerGenomeDUSP8
Protein Interactions : CTDDUSP8
Pharm GKB GenePA27531
PharosQ13202
Clinical trialDUSP8
Miscellaneous
canSAR (ICR)DUSP8
HarmonizomeDUSP8
ARCHS4DUSP8
DataMed IndexDUSP8
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDUSP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:31:24 CET 2022

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