DUT (deoxyuridine triphosphatase)

2006-10-01  

Identity

HGNC
LOCATION
15q21.1
LOCUSID
ALIAS
dUTPase
FUSION GENES

Other Information

Locus ID:

NCBI: 1854
MIM: 601266
HGNC: 3078
Ensembl: ENSG00000128951

Variants:

dbSNP: 1854
ClinVar: 1854
TCGA: ENSG00000128951
COSMIC: DUT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128951ENST00000331200P33316
ENSG00000128951ENST00000455976P33316
ENSG00000128951ENST00000558367H0YMP1
ENSG00000128951ENST00000558472H0YKC5
ENSG00000128951ENST00000558813A0A0C4DGL3
ENSG00000128951ENST00000558978H0YKI0
ENSG00000128951ENST00000559416H0YNW5
ENSG00000128951ENST00000559540H0YNJ9
ENSG00000128951ENST00000559935H0YMM5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine biosynthesisREACTOMER-HSA-500753

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
178485622007Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme.30
120963362002Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.25
221724892012Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer.23
178809432007Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.22
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
190151552009Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage.14
243115902013Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.13
193027842009Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers.11
217809052011Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.10
194036292009Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population.8

Citation

Dessen P

DUT (deoxyuridine triphosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43233/dut