Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

DUX4 (double homeobox 4)

Identity

Alias (NCBI)DUX4L
HGNC (Hugo) DUX4
LocusID (NCBI) 100288687
Atlas_Id 54984
Location 4q35.2  [Link to chromosome band 4q35]
Location_base_pair Starts at 190173774 and ends at 190175845 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CIC 19q13.2 / DUX4 4q35.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(4;4)(q26;q35) DUX4/CEP170P1
t(4;10)(q35;q26) DUX4/FRG2B
t(4;14)(q35;q32) DUX4/IGH
t(4;14)(q35;q32) IGH/DUX4
t(4;21)(q35;q22) DUX4/ERG
t(4;21)(q35;q22) ERG/DUX4


External links

 

Nomenclature
HGNC (Hugo)DUX4   50800
Cards
Entrez_Gene (NCBI)DUX4    double homeobox 4
AliasesDUX4L
GeneCards (Weizmann)DUX4
Ensembl hg19 (Hinxton)ENSG00000260596 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000260596 [Gene_View]  ENSG00000260596 [Sequence]  chr4:190173774-190175845 [Contig_View]  DUX4 [Vega]
ICGC DataPortalENSG00000260596
TCGA cBioPortalDUX4
AceView (NCBI)DUX4
Genatlas (Paris)DUX4
SOURCE (Princeton)DUX4
Genetics Home Reference (NIH)DUX4
Genomic and cartography
GoldenPath hg38 (UCSC)DUX4  -     chr4:190173774-190175845 +  4q35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DUX4  -     4q35.2   [Description]    (hg19-Feb_2009)
GoldenPathDUX4 - 4q35.2 [CytoView hg19]  DUX4 - 4q35.2 [CytoView hg38]
ImmunoBaseENSG00000260596
Genome Data Viewer NCBIDUX4 [Mapview hg19]  
OMIM606009   
Gene and transcription
Genbank (Entrez)HQ266760 HQ266761 HQ266762 HQ266764 HQ266765
RefSeq transcript (Entrez)NM_001205218 NM_001278056 NM_001293798 NM_001306068 NM_001363820
Consensus coding sequences : CCDS (NCBI)DUX4
Gene ExpressionDUX4 [ NCBI-GEO ]   DUX4 [ EBI - ARRAY_EXPRESS ]   DUX4 [ SEEK ]   DUX4 [ MEM ]
Gene Expression Viewer (FireBrowse)DUX4 [ Firebrowse - Broad ]
GenevisibleExpression of DUX4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)100288687
GTEX Portal (Tissue expression)DUX4
Human Protein AtlasENSG00000260596-DUX4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBX2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBX2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBX2
PhosPhoSitePlusQ9UBX2
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_dom    HTH_motif   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)DUX4
PDB (RSDB)5Z2S    5Z2T    5Z6Z    5ZFW    5ZFY    5ZFZ    6A8R    6DFY    6E8C    6U81    6U82   
PDB Europe5Z2S    5Z2T    5Z6Z    5ZFW    5ZFY    5ZFZ    6A8R    6DFY    6E8C    6U81    6U82   
PDB (PDBSum)5Z2S    5Z2T    5Z6Z    5ZFW    5ZFY    5ZFZ    6A8R    6DFY    6E8C    6U81    6U82   
PDB (IMB)5Z2S    5Z2T    5Z6Z    5ZFW    5ZFY    5ZFZ    6A8R    6DFY    6E8C    6U81    6U82   
Structural Biology KnowledgeBase5Z2S    5Z2T    5Z6Z    5ZFW    5ZFY    5ZFZ    6A8R    6DFY    6E8C    6U81    6U82   
SCOP (Structural Classification of Proteins)5Z2S    5Z2T    5Z6Z    5ZFW    5ZFY    5ZFZ    6A8R    6DFY    6E8C    6U81    6U82   
CATH (Classification of proteins structures)5Z2S    5Z2T    5Z6Z    5ZFW    5ZFY    5ZFZ    6A8R    6DFY    6E8C    6U81    6U82   
SuperfamilyQ9UBX2
AlphaFold pdb e-kbQ9UBX2   
Human Protein Atlas [tissue]ENSG00000260596-DUX4 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9UBX2
IntAct (EBI)Q9UBX2
BioGRIDDUX4
STRING (EMBL)DUX4
ZODIACDUX4
Ontologies - Pathways
QuickGOQ9UBX2
Ontology : AmiGOtranscription cis-regulatory region binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  Golgi apparatus  cytosol  regulation of transcription by RNA polymerase II  apoptotic process  multicellular organism development  negative regulation of cell population proliferation  nuclear membrane  positive regulation of transcription by RNA polymerase II  negative regulation of G0 to G1 transition  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBItranscription cis-regulatory region binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  Golgi apparatus  cytosol  regulation of transcription by RNA polymerase II  apoptotic process  multicellular organism development  negative regulation of cell population proliferation  nuclear membrane  positive regulation of transcription by RNA polymerase II  negative regulation of G0 to G1 transition  sequence-specific double-stranded DNA binding  
NDEx NetworkDUX4
Atlas of Cancer Signalling NetworkDUX4
Wikipedia pathwaysDUX4
Orthology - Evolution
OrthoDB100288687
GeneTree (enSembl)ENSG00000260596
Phylogenetic Trees/Animal Genes : TreeFamDUX4
Homologs : HomoloGeneDUX4
Homology/Alignments : Family Browser (UCSC)DUX4
Gene fusions - Rearrangements
Fusion : MitelmanCIC/DUX4 [19q13.2/-]  
Fusion : QuiverDUX4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDUX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DUX4
dbVarDUX4
ClinVarDUX4
MonarchDUX4
1000_GenomesDUX4 
Exome Variant ServerDUX4
GNOMAD BrowserENSG00000260596
Varsome BrowserDUX4
ACMGDUX4 variants
VarityQ9UBX2
Genomic Variants (DGV)DUX4 [DGVbeta]
DECIPHERDUX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDUX4 
Mutations
ICGC Data PortalDUX4 
TCGA Data PortalDUX4 
Broad Tumor PortalDUX4
OASIS PortalDUX4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDUX4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDUX4
DgiDB (Drug Gene Interaction Database)DUX4
DoCM (Curated mutations)DUX4
CIViC (Clinical Interpretations of Variants in Cancer)DUX4
Cancer3DDUX4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606009   
Orphanet
DisGeNETDUX4
MedgenDUX4
Genetic Testing Registry DUX4
NextProtQ9UBX2 [Medical]
GENETestsDUX4
Target ValidationDUX4
Huge Navigator DUX4 [HugePedia]
ClinGenDUX4
Clinical trials, drugs, therapy
MyCancerGenomeDUX4
Protein Interactions : CTDDUX4
Pharm GKB GenePA166180605
Pharm GKB PathwaysPA27538   
PharosQ9UBX2
Clinical trialDUX4
Miscellaneous
canSAR (ICR)DUX4
HarmonizomeDUX4
DataMed IndexDUX4
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDUX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:07:30 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.