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DVL2 (dishevelled segment polarity protein 2)

Identity

Alias_namesdishevelled 2 (homologous to Drosophila dsh)
dishevelled, dsh homolog 2 (Drosophila)
Other alias-
HGNC (Hugo) DVL2
LocusID (NCBI) 1856
Atlas_Id 50709
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7128661 and ends at 7137863 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DVL2 (17p13.1) / BTBD2 (19p13.3)DVL2 (17p13.1) / MAP3K10 (19q13.2)DVL2 (17p13.1) / RNMTL1 (17p13.3)
DVL2 (17p13.1) / TFE3 (Xp11.23)GRHPR (9p13.2) / DVL2 (17p13.1)RNMTL1 (17p13.3) / DVL2 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;17)(p36;q21) WNT3 or NSF/PRDM16


External links

Nomenclature
HGNC (Hugo)DVL2   3086
Cards
Entrez_Gene (NCBI)DVL2  1856  dishevelled segment polarity protein 2
Aliases
GeneCards (Weizmann)DVL2
Ensembl hg19 (Hinxton)ENSG00000004975 [Gene_View]  chr17:7128661-7137863 [Contig_View]  DVL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000004975 [Gene_View]  chr17:7128661-7137863 [Contig_View]  DVL2 [Vega]
ICGC DataPortalENSG00000004975
TCGA cBioPortalDVL2
AceView (NCBI)DVL2
Genatlas (Paris)DVL2
WikiGenes1856
SOURCE (Princeton)DVL2
Genetics Home Reference (NIH)DVL2
Genomic and cartography
GoldenPath hg19 (UCSC)DVL2  -     chr17:7128661-7137863 -  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DVL2  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblDVL2 - 17p13.1 [CytoView hg19]  DVL2 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIDVL2 [Mapview hg19]  DVL2 [Mapview hg38]
OMIM602151   
Gene and transcription
Genbank (Entrez)AF006012 AK026019 AK297099 AK297285 AK304229
RefSeq transcript (Entrez)NM_004422
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_033038 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)DVL2
Cluster EST : UnigeneHs.118640 [ NCBI ]
CGAP (NCI)Hs.118640
Alternative Splicing GalleryENSG00000004975
Gene ExpressionDVL2 [ NCBI-GEO ]   DVL2 [ EBI - ARRAY_EXPRESS ]   DVL2 [ SEEK ]   DVL2 [ MEM ]
Gene Expression Viewer (FireBrowse)DVL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1856
GTEX Portal (Tissue expression)DVL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14641   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14641  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14641
Splice isoforms : SwissVarO14641
PhosPhoSitePlusO14641
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    DIX (PS50841)    PDZ (PS50106)   
Domains : Interpro (EBI)DEP_dom    Dishevelled_C-dom    Dishevelled_fam    Dishevelled_protein_dom    DIX    Dsh/Dvl-rel    DVL2    PDZ    Ubiquitin-rel_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEP (PF00610)    Dishevelled (PF02377)    DIX (PF00778)    Dsh_C (PF12316)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00610    pfam02377    pfam00778    pfam12316    pfam00595   
Domain families : Smart (EMBL)DAX (SM00021)  DEP (SM00049)  PDZ (SM00228)  
Conserved Domain (NCBI)DVL2
DMDM Disease mutations1856
Blocks (Seattle)DVL2
PDB (SRS)2REY    3CBX    3CBY    3CBZ    3CC0    4WIP   
PDB (PDBSum)2REY    3CBX    3CBY    3CBZ    3CC0    4WIP   
PDB (IMB)2REY    3CBX    3CBY    3CBZ    3CC0    4WIP   
PDB (RSDB)2REY    3CBX    3CBY    3CBZ    3CC0    4WIP   
Structural Biology KnowledgeBase2REY    3CBX    3CBY    3CBZ    3CC0    4WIP   
SCOP (Structural Classification of Proteins)2REY    3CBX    3CBY    3CBZ    3CC0    4WIP   
CATH (Classification of proteins structures)2REY    3CBX    3CBY    3CBZ    3CC0    4WIP   
SuperfamilyO14641
Human Protein AtlasENSG00000004975
Peptide AtlasO14641
HPRD03690
IPIIPI00023103   
Protein Interaction databases
DIP (DOE-UCLA)O14641
IntAct (EBI)O14641
FunCoupENSG00000004975
BioGRIDDVL2
STRING (EMBL)DVL2
ZODIACDVL2
Ontologies - Pathways
QuickGOO14641
Ontology : AmiGOneural tube closure  positive regulation of protein phosphorylation  outflow tract morphogenesis  frizzled binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  transcription from RNA polymerase II promoter  segment specification  heart development  Wnt signaling pathway  protein kinase binding  protein domain specific binding  convergent extension involved in neural plate elongation  protein binding, bridging  cytoplasmic vesicle  cellular protein localization  hippo signaling  non-canonical Wnt signaling pathway  identical protein binding  positive regulation of JUN kinase activity  positive regulation of JUN kinase activity  positive regulation of GTPase activity  protein self-association  canonical Wnt signaling pathway involved in regulation of cell proliferation  apical part of cell  clathrin-coated endocytic vesicle  positive regulation of transcription, DNA-templated  Rac GTPase binding  positive regulation of sequence-specific DNA binding transcription factor activity  protein oligomerization  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  positive regulation of protein tyrosine kinase activity  negative regulation of canonical Wnt signaling pathway  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  positive regulation of canonical Wnt signaling pathway  beta-catenin destruction complex disassembly  
Ontology : EGO-EBIneural tube closure  positive regulation of protein phosphorylation  outflow tract morphogenesis  frizzled binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  transcription from RNA polymerase II promoter  segment specification  heart development  Wnt signaling pathway  protein kinase binding  protein domain specific binding  convergent extension involved in neural plate elongation  protein binding, bridging  cytoplasmic vesicle  cellular protein localization  hippo signaling  non-canonical Wnt signaling pathway  identical protein binding  positive regulation of JUN kinase activity  positive regulation of JUN kinase activity  positive regulation of GTPase activity  protein self-association  canonical Wnt signaling pathway involved in regulation of cell proliferation  apical part of cell  clathrin-coated endocytic vesicle  positive regulation of transcription, DNA-templated  Rac GTPase binding  positive regulation of sequence-specific DNA binding transcription factor activity  protein oligomerization  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  positive regulation of protein tyrosine kinase activity  negative regulation of canonical Wnt signaling pathway  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  positive regulation of canonical Wnt signaling pathway  beta-catenin destruction complex disassembly  
Pathways : KEGGWnt signaling pathway    Notch signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Basal cell carcinoma   
NDEx NetworkDVL2
Atlas of Cancer Signalling NetworkDVL2
Wikipedia pathwaysDVL2
Orthology - Evolution
OrthoDB1856
GeneTree (enSembl)ENSG00000004975
Phylogenetic Trees/Animal Genes : TreeFamDVL2
HOVERGENO14641
HOGENOMO14641
Homologs : HomoloGeneDVL2
Homology/Alignments : Family Browser (UCSC)DVL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDVL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DVL2
dbVarDVL2
ClinVarDVL2
1000_GenomesDVL2 
Exome Variant ServerDVL2
ExAC (Exome Aggregation Consortium)DVL2 (select the gene name)
Genetic variants : HAPMAP1856
Genomic Variants (DGV)DVL2 [DGVbeta]
DECIPHER (Syndromes)17:7128661-7137863  ENSG00000004975
CONAN: Copy Number AnalysisDVL2 
Mutations
ICGC Data PortalDVL2 
TCGA Data PortalDVL2 
Broad Tumor PortalDVL2
OASIS PortalDVL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDVL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDVL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DVL2
DgiDB (Drug Gene Interaction Database)DVL2
DoCM (Curated mutations)DVL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DVL2 (select a term)
intoGenDVL2
Cancer3DDVL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602151   
Orphanet
MedgenDVL2
Genetic Testing Registry DVL2
NextProtO14641 [Medical]
TSGene1856
GENETestsDVL2
Huge Navigator DVL2 [HugePedia]
snp3D : Map Gene to Disease1856
BioCentury BCIQDVL2
ClinGenDVL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1856
Chemical/Pharm GKB GenePA27542
Clinical trialDVL2
Miscellaneous
canSAR (ICR)DVL2 (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDVL2
EVEXDVL2
GoPubMedDVL2
iHOPDVL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:04:04 CET 2017

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