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DVL3 (dishevelled segment polarity protein 3)

Identity

Alias (NCBI)DRS3
HGNC (Hugo) DVL3
HGNC Alias symbKIAA0208
HGNC Previous namedishevelled 3 (homologous to Drosophila dsh)
 dishevelled, dsh homolog 3 (Drosophila)
LocusID (NCBI) 1857
Atlas_Id 50714
Location 3q27.1  [Link to chromosome band 3q27]
Location_base_pair Starts at 184155377 and ends at 184173614 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AD_1 () / DVL3 (3q27.1)DVL3 (3q27.1) / DVL3 (3q27.1)DVL3 (3q27.1) / PKP4 (2q24.1)
DVL3 (3q27.1) / SCN11A (3p22.2)NFASC (1q32.1) / DVL3 (3q27.1)STRN3 (14q12) / DVL3 (3q27.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;17)(p36;q21) WNT3 or NSF/PRDM16


External links

 

Nomenclature
HGNC (Hugo)DVL3   3087
Cards
Entrez_Gene (NCBI)DVL3    dishevelled segment polarity protein 3
AliasesDRS3
GeneCards (Weizmann)DVL3
Ensembl hg19 (Hinxton)ENSG00000161202 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161202 [Gene_View]  ENSG00000161202 [Sequence]  chr3:184155377-184173614 [Contig_View]  DVL3 [Vega]
ICGC DataPortalENSG00000161202
TCGA cBioPortalDVL3
AceView (NCBI)DVL3
Genatlas (Paris)DVL3
SOURCE (Princeton)DVL3
Genetics Home Reference (NIH)DVL3
Genomic and cartography
GoldenPath hg38 (UCSC)DVL3  -     chr3:184155377-184173614 +  3q27.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DVL3  -     3q27.1   [Description]    (hg19-Feb_2009)
GoldenPathDVL3 - 3q27.1 [CytoView hg19]  DVL3 - 3q27.1 [CytoView hg38]
ImmunoBaseENSG00000161202
Genome Data Viewer NCBIDVL3 [Mapview hg19]  
OMIM601368   616894   616894   
Gene and transcription
Genbank (Entrez)AF006013 AK093469 AK304686 AL110278 BC018289
RefSeq transcript (Entrez)NM_004423
Consensus coding sequences : CCDS (NCBI)DVL3
Gene ExpressionDVL3 [ NCBI-GEO ]   DVL3 [ EBI - ARRAY_EXPRESS ]   DVL3 [ SEEK ]   DVL3 [ MEM ]
Gene Expression Viewer (FireBrowse)DVL3 [ Firebrowse - Broad ]
GenevisibleExpression of DVL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1857
GTEX Portal (Tissue expression)DVL3
Human Protein AtlasENSG00000161202-DVL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92997   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92997  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92997
PhosPhoSitePlusQ92997
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    DIX (PS50841)    PDZ (PS50106)   
Domains : Interpro (EBI)DEP_dom    Dishevelled_C-dom    Dishevelled_fam    Dishevelled_protein_dom    DIX    DIX_dom_sf    Dsh/Dvl-rel    DVL3    PDZ    PDZ_sf    Ubiquitin-like_domsf    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)DEP (PF00610)    Dishevelled (PF02377)    DIX (PF00778)    Dsh_C (PF12316)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00610    pfam02377    pfam00778    pfam12316    pfam00595   
Domain families : Smart (EMBL)DAX (SM00021)  DEP (SM00049)  PDZ (SM00228)  
Conserved Domain (NCBI)DVL3
PDB (RSDB)6V7O   
PDB Europe6V7O   
PDB (PDBSum)6V7O   
PDB (IMB)6V7O   
Structural Biology KnowledgeBase6V7O   
SCOP (Structural Classification of Proteins)6V7O   
CATH (Classification of proteins structures)6V7O   
SuperfamilyQ92997
AlphaFold pdb e-kbQ92997   
Human Protein Atlas [tissue]ENSG00000161202-DVL3 [tissue]
HPRD03222
Protein Interaction databases
DIP (DOE-UCLA)Q92997
IntAct (EBI)Q92997
BioGRIDDVL3
STRING (EMBL)DVL3
ZODIACDVL3
Ontologies - Pathways
QuickGOQ92997
Ontology : AmiGOchromatin  positive regulation of protein phosphorylation  protease binding  signaling receptor binding  frizzled binding  frizzled binding  frizzled binding  protein binding  cytosol  cytosol  cytosol  beta-catenin binding  small GTPase binding  intracellular signal transduction  non-canonical Wnt signaling pathway  non-canonical Wnt signaling pathway  non-canonical Wnt signaling pathway via JNK cascade  response to drug  positive regulation of JUN kinase activity  positive regulation of GTPase activity  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein stabilization  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  planar cell polarity pathway involved in neural tube closure  positive regulation of neuron projection arborization  regulation of cellular protein localization  beta-catenin destruction complex disassembly  
Ontology : EGO-EBIchromatin  positive regulation of protein phosphorylation  protease binding  signaling receptor binding  frizzled binding  frizzled binding  frizzled binding  protein binding  cytosol  cytosol  cytosol  beta-catenin binding  small GTPase binding  intracellular signal transduction  non-canonical Wnt signaling pathway  non-canonical Wnt signaling pathway  non-canonical Wnt signaling pathway via JNK cascade  response to drug  positive regulation of JUN kinase activity  positive regulation of GTPase activity  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein stabilization  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  planar cell polarity pathway involved in neural tube closure  positive regulation of neuron projection arborization  regulation of cellular protein localization  beta-catenin destruction complex disassembly  
Pathways : KEGGWnt signaling pathway    Notch signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Basal cell carcinoma   
NDEx NetworkDVL3
Atlas of Cancer Signalling NetworkDVL3
Wikipedia pathwaysDVL3
Orthology - Evolution
OrthoDB1857
GeneTree (enSembl)ENSG00000161202
Phylogenetic Trees/Animal Genes : TreeFamDVL3
Homologs : HomoloGeneDVL3
Homology/Alignments : Family Browser (UCSC)DVL3
Gene fusions - Rearrangements
Fusion Cancer (Beijing)AD_1 [DVL3]  -  3q27.1 [FUSC001132]
Fusion : QuiverDVL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDVL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DVL3
dbVarDVL3
ClinVarDVL3
MonarchDVL3
1000_GenomesDVL3 
Exome Variant ServerDVL3
GNOMAD BrowserENSG00000161202
Varsome BrowserDVL3
ACMGDVL3 variants
VarityQ92997
Genomic Variants (DGV)DVL3 [DGVbeta]
DECIPHERDVL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDVL3 
Mutations
ICGC Data PortalDVL3 
TCGA Data PortalDVL3 
Broad Tumor PortalDVL3
OASIS PortalDVL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDVL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDVL3
Mutations and Diseases : HGMDDVL3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDVL3
DgiDB (Drug Gene Interaction Database)DVL3
DoCM (Curated mutations)DVL3
CIViC (Clinical Interpretations of Variants in Cancer)DVL3
Cancer3DDVL3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601368    616894    616894   
Orphanet2781   
DisGeNETDVL3
MedgenDVL3
Genetic Testing Registry DVL3
NextProtQ92997 [Medical]
GENETestsDVL3
Target ValidationDVL3
Huge Navigator DVL3 [HugePedia]
ClinGenDVL3
Clinical trials, drugs, therapy
MyCancerGenomeDVL3
Protein Interactions : CTDDVL3
Pharm GKB GenePA27543
PharosQ92997
Clinical trialDVL3
Miscellaneous
canSAR (ICR)DVL3
HarmonizomeDVL3
DataMed IndexDVL3
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDVL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:07:31 CEST 2021

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