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DVL3 (dishevelled segment polarity protein 3)

Identity

Alias_namesdishevelled 3 (homologous to Drosophila dsh)
dishevelled, dsh homolog 3 (Drosophila)
Alias_symbol (synonym)KIAA0208
Other aliasDRS3
HGNC (Hugo) DVL3
LocusID (NCBI) 1857
Atlas_Id 50714
Location 3q27.1  [Link to chromosome band 3q27]
Location_base_pair Starts at 184155496 and ends at 184173526 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AD_1 () / DVL3 (3q27.1)DVL3 (3q27.1) / DVL3 (3q27.1)DVL3 (3q27.1) / PKP4 (2q24.1)
DVL3 (3q27.1) / SCN11A (3p22.2)NFASC (1q32.1) / DVL3 (3q27.1)STRN3 (14q12) / DVL3 (3q27.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;17)(p36;q21) WNT3 or NSF/PRDM16


External links

Nomenclature
HGNC (Hugo)DVL3   3087
Cards
Entrez_Gene (NCBI)DVL3  1857  dishevelled segment polarity protein 3
AliasesDRS3
GeneCards (Weizmann)DVL3
Ensembl hg19 (Hinxton)ENSG00000161202 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161202 [Gene_View]  chr3:184155496-184173526 [Contig_View]  DVL3 [Vega]
ICGC DataPortalENSG00000161202
TCGA cBioPortalDVL3
AceView (NCBI)DVL3
Genatlas (Paris)DVL3
WikiGenes1857
SOURCE (Princeton)DVL3
Genetics Home Reference (NIH)DVL3
Genomic and cartography
GoldenPath hg38 (UCSC)DVL3  -     chr3:184155496-184173526 +  3q27.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DVL3  -     3q27.1   [Description]    (hg19-Feb_2009)
EnsemblDVL3 - 3q27.1 [CytoView hg19]  DVL3 - 3q27.1 [CytoView hg38]
Mapping of homologs : NCBIDVL3 [Mapview hg19]  DVL3 [Mapview hg38]
OMIM601368   616894   
Gene and transcription
Genbank (Entrez)AF006013 AK093469 AK304686 AL110278 BC018289
RefSeq transcript (Entrez)NM_004423
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DVL3
Cluster EST : UnigeneHs.388116 [ NCBI ]
CGAP (NCI)Hs.388116
Alternative Splicing GalleryENSG00000161202
Gene ExpressionDVL3 [ NCBI-GEO ]   DVL3 [ EBI - ARRAY_EXPRESS ]   DVL3 [ SEEK ]   DVL3 [ MEM ]
Gene Expression Viewer (FireBrowse)DVL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1857
GTEX Portal (Tissue expression)DVL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92997   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92997  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92997
Splice isoforms : SwissVarQ92997
PhosPhoSitePlusQ92997
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    DIX (PS50841)    PDZ (PS50106)   
Domains : Interpro (EBI)DEP_dom    Dishevelled_C-dom    Dishevelled_fam    Dishevelled_protein_dom    DIX    Dsh/Dvl-rel    DVL3    PDZ    Ubiquitin-rel_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEP (PF00610)    Dishevelled (PF02377)    DIX (PF00778)    Dsh_C (PF12316)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00610    pfam02377    pfam00778    pfam12316    pfam00595   
Domain families : Smart (EMBL)DAX (SM00021)  DEP (SM00049)  PDZ (SM00228)  
Conserved Domain (NCBI)DVL3
DMDM Disease mutations1857
Blocks (Seattle)DVL3
SuperfamilyQ92997
Human Protein AtlasENSG00000161202
Peptide AtlasQ92997
HPRD03222
IPIIPI00643141   IPI00791929   IPI00383832   IPI00924552   IPI00927838   IPI00927659   
Protein Interaction databases
DIP (DOE-UCLA)Q92997
IntAct (EBI)Q92997
FunCoupENSG00000161202
BioGRIDDVL3
STRING (EMBL)DVL3
ZODIACDVL3
Ontologies - Pathways
QuickGOQ92997
Ontology : AmiGOnuclear chromatin  positive regulation of protein phosphorylation  protease binding  outflow tract septum morphogenesis  receptor binding  frizzled binding  protein binding  cytosol  cytosol  beta-catenin binding  Wnt signaling pathway  protein binding, bridging  intracellular signal transduction  non-canonical Wnt signaling pathway  non-canonical Wnt signaling pathway via JNK cascade  response to drug  positive regulation of JUN kinase activity  positive regulation of GTPase activity  positive regulation of transcription, DNA-templated  protein heterodimerization activity  Rac GTPase binding  protein stabilization  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  regulation of cellular protein localization  beta-catenin destruction complex disassembly  Wnt signalosome  
Ontology : EGO-EBInuclear chromatin  positive regulation of protein phosphorylation  protease binding  outflow tract septum morphogenesis  receptor binding  frizzled binding  protein binding  cytosol  cytosol  beta-catenin binding  Wnt signaling pathway  protein binding, bridging  intracellular signal transduction  non-canonical Wnt signaling pathway  non-canonical Wnt signaling pathway via JNK cascade  response to drug  positive regulation of JUN kinase activity  positive regulation of GTPase activity  positive regulation of transcription, DNA-templated  protein heterodimerization activity  Rac GTPase binding  protein stabilization  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  negative regulation of canonical Wnt signaling pathway  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  regulation of cellular protein localization  beta-catenin destruction complex disassembly  Wnt signalosome  
Pathways : KEGGWnt signaling pathway    Notch signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Basal cell carcinoma   
NDEx NetworkDVL3
Atlas of Cancer Signalling NetworkDVL3
Wikipedia pathwaysDVL3
Orthology - Evolution
OrthoDB1857
GeneTree (enSembl)ENSG00000161202
Phylogenetic Trees/Animal Genes : TreeFamDVL3
HOVERGENQ92997
HOGENOMQ92997
Homologs : HomoloGeneDVL3
Homology/Alignments : Family Browser (UCSC)DVL3
Gene fusions - Rearrangements
Fusion Cancer (Beijing)AD_1 [DVL3]  -  3q27.1 [FUSC001132]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDVL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DVL3
dbVarDVL3
ClinVarDVL3
1000_GenomesDVL3 
Exome Variant ServerDVL3
ExAC (Exome Aggregation Consortium)DVL3 (select the gene name)
Genetic variants : HAPMAP1857
Genomic Variants (DGV)DVL3 [DGVbeta]
DECIPHERDVL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDVL3 
Mutations
ICGC Data PortalDVL3 
TCGA Data PortalDVL3 
Broad Tumor PortalDVL3
OASIS PortalDVL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDVL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDVL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DVL3
DgiDB (Drug Gene Interaction Database)DVL3
DoCM (Curated mutations)DVL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DVL3 (select a term)
intoGenDVL3
Cancer3DDVL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601368    616894   
Orphanet2781   
MedgenDVL3
Genetic Testing Registry DVL3
NextProtQ92997 [Medical]
TSGene1857
GENETestsDVL3
Huge Navigator DVL3 [HugePedia]
snp3D : Map Gene to Disease1857
BioCentury BCIQDVL3
ClinGenDVL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1857
Chemical/Pharm GKB GenePA27543
Clinical trialDVL3
Miscellaneous
canSAR (ICR)DVL3 (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDVL3
EVEXDVL3
GoPubMedDVL3
iHOPDVL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:14:04 CEST 2017

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