DVL3 (dishevelled segment polarity protein 3)

2009-03-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
DRS3
FUSION GENES

Other Information

Locus ID:

NCBI: 1857
MIM: 601368
HGNC: 3087
Ensembl: ENSG00000161202

Variants:

dbSNP: 1857
ClinVar: 1857
TCGA: ENSG00000161202
COSMIC: DVL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161202ENST00000313143Q92997
ENSG00000161202ENST00000431765Q92997
ENSG00000161202ENST00000435708F8WCF1
ENSG00000161202ENST00000649364A0A3B3ISG4
ENSG00000161202ENST00000649847A0A3B3ITC6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
Notch signaling pathwayKEGGko04330
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
Notch signaling pathwayKEGGhsa04330
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
WNT mediated activation of DVLREACTOMER-HSA-201688
Disassembly of the destruction complex and recruitment of AXIN to the membraneREACTOMER-HSA-4641262
Degradation of DVLREACTOMER-HSA-4641258
Negative regulation of TCF-dependent signaling by DVL-interacting proteinsREACTOMER-HSA-5368598
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180938022008Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.60
170301912006Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer.46
260087362016Gene expression in major depressive disorder.43
249938222014Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5.28
233010942013AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity.27
277443182016Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.25
269245302016DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.24
201370802010Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.23
186929362008Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.21
258470802015miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling.19

Citation

Dessen P

DVL3 (dishevelled segment polarity protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50714/dvl3