DXO (decapping exoribonuclease)

2014-11-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
DOM3L,DOM3Z,NG6,RAI1
FUSION GENES

Other Information

Locus ID:

NCBI: 1797
MIM: 605996
HGNC: 2992
Ensembl: ENSG00000204348

Variants:

dbSNP: 1797
ClinVar: 1797
TCGA: ENSG00000204348
COSMIC: DXO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204348ENST00000337523O77932
ENSG00000204348ENST00000337523A0A024RCW8
ENSG00000204348ENST00000375349O77932
ENSG00000204348ENST00000375349A0A024RCW8
ENSG00000204348ENST00000375356O77932
ENSG00000204348ENST00000375356A0A024RCW8
ENSG00000204348ENST00000480240F8WC68
ENSG00000204348ENST00000495340H7C5D2

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
296727162018miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11.10
2960158420182'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO.9

Citation

Dessen P

DXO (decapping exoribonuclease)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62684/dxo