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DXO (decapping exoribonuclease)

Identity

Alias (NCBI)DOM3L
DOM3Z
NG6
RAI1
HGNC (Hugo) DXO
HGNC Previous nameDOM3Z
HGNC Previous nameDOM-3 (C. elegans) homolog Z
 dom-3 homolog Z (C. elegans)
LocusID (NCBI) 1797
Atlas_Id 62684
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31969815 and ends at 31972138 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DXO (6p21.33) / CLK2 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DXO   2992
Cards
Entrez_Gene (NCBI)DXO    decapping exoribonuclease
AliasesDOM3L; DOM3Z; NG6; RAI1
GeneCards (Weizmann)DXO
Ensembl hg19 (Hinxton)ENSG00000204348 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204348 [Gene_View]  ENSG00000204348 [Sequence]  chr6:31969815-31972138 [Contig_View]  DXO [Vega]
ICGC DataPortalENSG00000204348
TCGA cBioPortalDXO
AceView (NCBI)DXO
Genatlas (Paris)DXO
SOURCE (Princeton)DXO
Genetics Home Reference (NIH)DXO
Genomic and cartography
GoldenPath hg38 (UCSC)DXO  -     chr6:31969815-31972138 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DXO  -     6p21.33   [Description]    (hg19-Feb_2009)
GoldenPathDXO - 6p21.33 [CytoView hg19]  DXO - 6p21.33 [CytoView hg38]
ImmunoBaseENSG00000204348
Genome Data Viewer NCBIDXO [Mapview hg19]  
OMIM605996   
Gene and transcription
Genbank (Entrez)AF059252 AF059253 AF059254 AK310107 BC009344
RefSeq transcript (Entrez)NM_001371205 NM_001371206 NM_005510
Consensus coding sequences : CCDS (NCBI)DXO
Gene ExpressionDXO [ NCBI-GEO ]   DXO [ EBI - ARRAY_EXPRESS ]   DXO [ SEEK ]   DXO [ MEM ]
Gene Expression Viewer (FireBrowse)DXO [ Firebrowse - Broad ]
GenevisibleExpression of DXO in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1797
GTEX Portal (Tissue expression)DXO
Human Protein AtlasENSG00000204348-DXO [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO77932   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO77932  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO77932
PhosPhoSitePlusO77932
Domains : Interpro (EBI)RAI1    RAI1-like_fam   
Domain families : Pfam (Sanger)RAI1 (PF08652)   
Domain families : Pfam (NCBI)pfam08652   
Conserved Domain (NCBI)DXO
SuperfamilyO77932
AlphaFold pdb e-kbO77932   
Human Protein Atlas [tissue]ENSG00000204348-DXO [tissue]
HPRD16186
Protein Interaction databases
DIP (DOE-UCLA)O77932
IntAct (EBI)O77932
BioGRIDDXO
STRING (EMBL)DXO
ZODIACDXO
Ontologies - Pathways
QuickGOO77932
Ontology : AmiGOnucleotide binding  magnesium ion binding  nuclear-transcribed mRNA catabolic process  mRNA binding  nucleus  nucleus  nucleoplasm  cytosol  cytosol  plasma membrane  mRNA catabolic process  mRNA catabolic process  5'-3' exonuclease activity  RNA pyrophosphohydrolase activity  RNA pyrophosphohydrolase activity  RNA destabilization  nuclear mRNA surveillance  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  RNA NAD-cap (NAD-forming) hydrolase activity  NAD-cap decapping  NAD-cap decapping  
Ontology : EGO-EBInucleotide binding  magnesium ion binding  nuclear-transcribed mRNA catabolic process  mRNA binding  nucleus  nucleus  nucleoplasm  cytosol  cytosol  plasma membrane  mRNA catabolic process  mRNA catabolic process  5'-3' exonuclease activity  RNA pyrophosphohydrolase activity  RNA pyrophosphohydrolase activity  RNA destabilization  nuclear mRNA surveillance  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  RNA NAD-cap (NAD-forming) hydrolase activity  NAD-cap decapping  NAD-cap decapping  
NDEx NetworkDXO
Atlas of Cancer Signalling NetworkDXO
Wikipedia pathwaysDXO
Orthology - Evolution
OrthoDB1797
GeneTree (enSembl)ENSG00000204348
Phylogenetic Trees/Animal Genes : TreeFamDXO
Homologs : HomoloGeneDXO
Homology/Alignments : Family Browser (UCSC)DXO
Gene fusions - Rearrangements
Fusion : QuiverDXO
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDXO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DXO
dbVarDXO
ClinVarDXO
MonarchDXO
1000_GenomesDXO 
Exome Variant ServerDXO
GNOMAD BrowserENSG00000204348
Varsome BrowserDXO
ACMGDXO variants
VarityO77932
Genomic Variants (DGV)DXO [DGVbeta]
DECIPHERDXO [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDXO 
Mutations
ICGC Data PortalDXO 
TCGA Data PortalDXO 
Broad Tumor PortalDXO
OASIS PortalDXO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDXO  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDXO
Mutations and Diseases : HGMDDXO
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDXO
DgiDB (Drug Gene Interaction Database)DXO
DoCM (Curated mutations)DXO
CIViC (Clinical Interpretations of Variants in Cancer)DXO
Cancer3DDXO
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605996   
Orphanet
DisGeNETDXO
MedgenDXO
Genetic Testing Registry DXO
NextProtO77932 [Medical]
GENETestsDXO
Target ValidationDXO
Huge Navigator DXO [HugePedia]
ClinGenDXO
Clinical trials, drugs, therapy
MyCancerGenomeDXO
Protein Interactions : CTDDXO
Pharm GKB GenePA27458
PharosO77932
Clinical trialDXO
Miscellaneous
canSAR (ICR)DXO
HarmonizomeDXO
DataMed IndexDXO
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDXO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:48:31 CEST 2021

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