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DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1)

Identity

Alias (NCBI)DNCI1
DNCIC1
HGNC (Hugo) DYNC1I1
HGNC Alias symbDNCIC1
HGNC Previous nameDNCI1
HGNC Previous namedynein, cytoplasmic, intermediate polypeptide 1
LocusID (NCBI) 1780
Atlas_Id 52486
Location 7q21.3  [Link to chromosome band 7q21]
Location_base_pair Starts at 95772506 and ends at 96098424 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IMMP2L (7q31.1) / DYNC1I1 (7q21.3)KMT2E (7q22.3) / DYNC1I1 (7q21.3)MET (7q31.2) / DYNC1I1 (7q21.3)
PTPN12 (7q11.23) / DYNC1I1 (7q21.3)SRPK2 (7q22.3) / DYNC1I1 (7q21.3)IMMP2L 7q31.1 / DYNC1I1 7q21.3
MET 7q31.2 / DYNC1I1 7q21.3PTPN12 7q11.23 / DYNC1I1 7q21.3SRPK2 7q22.3 / DYNC1I1 7q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DYNC1I1   2963
Cards
Entrez_Gene (NCBI)DYNC1I1    dynein cytoplasmic 1 intermediate chain 1
AliasesDNCI1; DNCIC1
GeneCards (Weizmann)DYNC1I1
Ensembl hg19 (Hinxton)ENSG00000158560 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158560 [Gene_View]  ENSG00000158560 [Sequence]  chr7:95772506-96098424 [Contig_View]  DYNC1I1 [Vega]
ICGC DataPortalENSG00000158560
TCGA cBioPortalDYNC1I1
AceView (NCBI)DYNC1I1
Genatlas (Paris)DYNC1I1
SOURCE (Princeton)DYNC1I1
Genetics Home Reference (NIH)DYNC1I1
Genomic and cartography
GoldenPath hg38 (UCSC)DYNC1I1  -     chr7:95772506-96098424 +  7q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DYNC1I1  -     7q21.3   [Description]    (hg19-Feb_2009)
GoldenPathDYNC1I1 - 7q21.3 [CytoView hg19]  DYNC1I1 - 7q21.3 [CytoView hg38]
ImmunoBaseENSG00000158560
Genome Data Viewer NCBIDYNC1I1 [Mapview hg19]  
OMIM603772   
Gene and transcription
Genbank (Entrez)AF063228 AF123074 AK091339 AK297427 AK309419
RefSeq transcript (Entrez)NM_001135556 NM_001135557 NM_001278421 NM_001278422 NM_004411
Consensus coding sequences : CCDS (NCBI)DYNC1I1
Gene ExpressionDYNC1I1 [ NCBI-GEO ]   DYNC1I1 [ EBI - ARRAY_EXPRESS ]   DYNC1I1 [ SEEK ]   DYNC1I1 [ MEM ]
Gene Expression Viewer (FireBrowse)DYNC1I1 [ Firebrowse - Broad ]
GenevisibleExpression of DYNC1I1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1780
GTEX Portal (Tissue expression)DYNC1I1
Human Protein AtlasENSG00000158560-DYNC1I1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14576   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14576  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14576
PhosPhoSitePlusO14576
Domaine pattern : Prosite (Expaxy)WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)DYNC1I1/DYNC1I2    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)Dynein_IC2 (PF11540)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam11540    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)DYNC1I1
SuperfamilyO14576
AlphaFold pdb e-kbO14576   
Human Protein Atlas [tissue]ENSG00000158560-DYNC1I1 [tissue]
HPRD04798
Protein Interaction databases
DIP (DOE-UCLA)O14576
IntAct (EBI)O14576
BioGRIDDYNC1I1
STRING (EMBL)DYNC1I1
ZODIACDYNC1I1
Ontologies - Pathways
QuickGOO14576
Ontology : AmiGOkinetochore  spindle pole  motor activity  microtubule motor activity  protein binding  nucleus  cytoplasm  cytosol  cytoplasmic dynein complex  cytoplasmic dynein complex  microtubule  endoplasmic reticulum to Golgi vesicle-mediated transport  microtubule-based movement  mitotic spindle organization  microtubule binding  transport along microtubule  viral life cycle  antigen processing and presentation of exogenous peptide antigen via MHC class II  spectrin binding  vesicle  aggrephagy  cytoplasmic ribonucleoprotein granule  dynein light chain binding  dynein heavy chain binding  vesicle transport along microtubule  vesicle transport along microtubule  perinuclear region of cytoplasm  recycling endosome  
Ontology : EGO-EBIkinetochore  spindle pole  motor activity  microtubule motor activity  protein binding  nucleus  cytoplasm  cytosol  cytoplasmic dynein complex  cytoplasmic dynein complex  microtubule  endoplasmic reticulum to Golgi vesicle-mediated transport  microtubule-based movement  mitotic spindle organization  microtubule binding  transport along microtubule  viral life cycle  antigen processing and presentation of exogenous peptide antigen via MHC class II  spectrin binding  vesicle  aggrephagy  cytoplasmic ribonucleoprotein granule  dynein light chain binding  dynein heavy chain binding  vesicle transport along microtubule  vesicle transport along microtubule  perinuclear region of cytoplasm  recycling endosome  
Pathways : KEGGPhagosome    Vasopressin-regulated water reabsorption    Salmonella infection   
NDEx NetworkDYNC1I1
Atlas of Cancer Signalling NetworkDYNC1I1
Wikipedia pathwaysDYNC1I1
Orthology - Evolution
OrthoDB1780
GeneTree (enSembl)ENSG00000158560
Phylogenetic Trees/Animal Genes : TreeFamDYNC1I1
Homologs : HomoloGeneDYNC1I1
Homology/Alignments : Family Browser (UCSC)DYNC1I1
Gene fusions - Rearrangements
Fusion : MitelmanIMMP2L/DYNC1I1 [7q31.1/7q21.3]  
Fusion : MitelmanMET/DYNC1I1 [7q31.2/7q21.3]  
Fusion : MitelmanPTPN12/DYNC1I1 [7q11.23/7q21.3]  
Fusion : MitelmanSRPK2/DYNC1I1 [7q22.3/7q21.3]  
Fusion : QuiverDYNC1I1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYNC1I1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYNC1I1
dbVarDYNC1I1
ClinVarDYNC1I1
MonarchDYNC1I1
1000_GenomesDYNC1I1 
Exome Variant ServerDYNC1I1
GNOMAD BrowserENSG00000158560
Varsome BrowserDYNC1I1
ACMGDYNC1I1 variants
VarityO14576
Genomic Variants (DGV)DYNC1I1 [DGVbeta]
DECIPHERDYNC1I1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDYNC1I1 
Mutations
ICGC Data PortalDYNC1I1 
TCGA Data PortalDYNC1I1 
Broad Tumor PortalDYNC1I1
OASIS PortalDYNC1I1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYNC1I1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDYNC1I1
Mutations and Diseases : HGMDDYNC1I1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDYNC1I1
DgiDB (Drug Gene Interaction Database)DYNC1I1
DoCM (Curated mutations)DYNC1I1
CIViC (Clinical Interpretations of Variants in Cancer)DYNC1I1
Cancer3DDYNC1I1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603772   
Orphanet
DisGeNETDYNC1I1
MedgenDYNC1I1
Genetic Testing Registry DYNC1I1
NextProtO14576 [Medical]
GENETestsDYNC1I1
Target ValidationDYNC1I1
Huge Navigator DYNC1I1 [HugePedia]
ClinGenDYNC1I1
Clinical trials, drugs, therapy
MyCancerGenomeDYNC1I1
Protein Interactions : CTDDYNC1I1
Pharm GKB GenePA27434
PharosO14576
Clinical trialDYNC1I1
Miscellaneous
canSAR (ICR)DYNC1I1
HarmonizomeDYNC1I1
DataMed IndexDYNC1I1
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDYNC1I1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:32 CEST 2021

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