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DYNC1I2 (dynein, cytoplasmic 1, intermediate chain 2)

Identity

Alias_namesDNCI2
dynein, cytoplasmic, intermediate polypeptide 2
Alias_symbol (synonym)DIC74
Other aliasIC2
HGNC (Hugo) DYNC1I2
LocusID (NCBI) 1781
Atlas_Id 62688
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 172544182 and ends at 172606668 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BCYRN1 (Xq13.1) / DYNC1I2 (2q31.1)DYNC1I2 (2q31.1) / BRE (2p23.2)DYNC1I2 (2q31.1) / DYNC1I2 (2q31.1)
DYNC1I2 (2q31.1) / HNRNPA2B1 (7p15.2)GNAQ (9q21.2) / DYNC1I2 (2q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DYNC1I2   2964
Cards
Entrez_Gene (NCBI)DYNC1I2  1781  dynein, cytoplasmic 1, intermediate chain 2
AliasesDNCI2; IC2
GeneCards (Weizmann)DYNC1I2
Ensembl hg19 (Hinxton) [Gene_View]  chr2:172544182-172606668 [Contig_View]  DYNC1I2 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:172544182-172606668 [Contig_View]  DYNC1I2 [Vega]
TCGA cBioPortalDYNC1I2
AceView (NCBI)DYNC1I2
Genatlas (Paris)DYNC1I2
WikiGenes1781
SOURCE (Princeton)DYNC1I2
Genetics Home Reference (NIH)DYNC1I2
Genomic and cartography
GoldenPath hg19 (UCSC)DYNC1I2  -     chr2:172544182-172606668 +  2q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DYNC1I2  -     2q31.1   [Description]    (hg38-Dec_2013)
EnsemblDYNC1I2 - 2q31.1 [CytoView hg19]  DYNC1I2 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBIDYNC1I2 [Mapview hg19]  DYNC1I2 [Mapview hg38]
OMIM603331   
Gene and transcription
Genbank (Entrez)AB209014 AF134477 AF250307 AK024742 AK026574
RefSeq transcript (Entrez)NM_001271785 NM_001271786 NM_001271787 NM_001271788 NM_001271789 NM_001271790 NM_001378
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)DYNC1I2
Cluster EST : UnigeneHs.546250 [ NCBI ]
CGAP (NCI)Hs.546250
Gene ExpressionDYNC1I2 [ NCBI-GEO ]   DYNC1I2 [ EBI - ARRAY_EXPRESS ]   DYNC1I2 [ SEEK ]   DYNC1I2 [ MEM ]
Gene Expression Viewer (FireBrowse)DYNC1I2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1781
GTEX Portal (Tissue expression)DYNC1I2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13409   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13409  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13409
Splice isoforms : SwissVarQ13409
PhosPhoSitePlusQ13409
Domaine pattern : Prosite (Expaxy)WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Dynein_IC_1/2    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)Dynein_IC2 (PF11540)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam11540    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)DYNC1I2
DMDM Disease mutations1781
Blocks (Seattle)DYNC1I2
SuperfamilyQ13409
Peptide AtlasQ13409
HPRD04512
IPIIPI00744015   IPI00302712   IPI00216348   IPI00827859   IPI00827813   IPI01015321   IPI00915993   IPI00917180   IPI00917325   IPI00917978   IPI00917564   IPI00917075   IPI00917785   IPI00916278   IPI00915884   IPI00917685   IPI00916160   IPI00412601   IPI00916306   
Protein Interaction databases
DIP (DOE-UCLA)Q13409
IntAct (EBI)Q13409
BioGRIDDYNC1I2
STRING (EMBL)DYNC1I2
ZODIACDYNC1I2
Ontologies - Pathways
QuickGOQ13409
Ontology : AmiGOG2/M transition of mitotic cell cycle  mitotic cell cycle  microtubule motor activity  protein binding  cytoplasm  centrosome  cytosol  cytoplasmic dynein complex  microtubule  transport  organelle organization  microtubule-based movement  metabolic process  metabolic process  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  vesicle  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  mitotic cell cycle  microtubule motor activity  protein binding  cytoplasm  centrosome  cytosol  cytoplasmic dynein complex  microtubule  transport  organelle organization  microtubule-based movement  metabolic process  metabolic process  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  vesicle  
Pathways : KEGGPhagosome    Vasopressin-regulated water reabsorption    Salmonella infection   
NDEx NetworkDYNC1I2
Atlas of Cancer Signalling NetworkDYNC1I2
Wikipedia pathwaysDYNC1I2
Orthology - Evolution
OrthoDB1781
Phylogenetic Trees/Animal Genes : TreeFamDYNC1I2
HOVERGENQ13409
HOGENOMQ13409
Homologs : HomoloGeneDYNC1I2
Homology/Alignments : Family Browser (UCSC)DYNC1I2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYNC1I2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYNC1I2
dbVarDYNC1I2
ClinVarDYNC1I2
1000_GenomesDYNC1I2 
Exome Variant ServerDYNC1I2
ExAC (Exome Aggregation Consortium)DYNC1I2 (select the gene name)
Genetic variants : HAPMAP1781
Genomic Variants (DGV)DYNC1I2 [DGVbeta]
DECIPHER (Syndromes)2:172544182-172606668  
CONAN: Copy Number AnalysisDYNC1I2 
Mutations
ICGC Data PortalDYNC1I2 
TCGA Data PortalDYNC1I2 
Broad Tumor PortalDYNC1I2
OASIS PortalDYNC1I2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYNC1I2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDYNC1I2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DYNC1I2
DgiDB (Drug Gene Interaction Database)DYNC1I2
DoCM (Curated mutations)DYNC1I2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYNC1I2 (select a term)
intoGenDYNC1I2
Cancer3DDYNC1I2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603331   
Orphanet
MedgenDYNC1I2
Genetic Testing Registry DYNC1I2
NextProtQ13409 [Medical]
TSGene1781
GENETestsDYNC1I2
Huge Navigator DYNC1I2 [HugePedia]
snp3D : Map Gene to Disease1781
BioCentury BCIQDYNC1I2
ClinGenDYNC1I2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1781
Chemical/Pharm GKB GenePA27435
Clinical trialDYNC1I2
Miscellaneous
canSAR (ICR)DYNC1I2 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYNC1I2
EVEXDYNC1I2
GoPubMedDYNC1I2
iHOPDYNC1I2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 12:02:23 CET 2017

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