DYNLL1 (dynein light chain LC8-type 1)

2007-02-01  

Identity

HGNC
DYNLL1
LOCATION
12q24.31
LOCUSID
8655
ALIAS
DLC1,DLC8,DNCL1,DNCLC1,LC8,LC8a,PIN,hdlc1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8655
MIM: 601562
HGNC: 15476
Ensembl: ENSG00000088986

Variants:

dbSNP: 8655
ClinVar: 8655
TCGA: ENSG00000088986
COSMIC: DYNLL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088986ENST00000242577P63167
ENSG00000088986ENST00000242577Q6FGH9
ENSG00000088986ENST00000392508P63167
ENSG00000088986ENST00000392508Q6FGH9
ENSG00000088986ENST00000392509P63167
ENSG00000088986ENST00000392509Q6FGH9
ENSG00000088986ENST00000548214F8VRV5
ENSG00000088986ENST00000548342P63167
ENSG00000088986ENST00000548342Q6FGH9
ENSG00000088986ENST00000549649F8VXI7
ENSG00000088986ENST00000549989P63167
ENSG00000088986ENST00000549989Q6FGH9
ENSG00000088986ENST00000550178F8VRV5
ENSG00000088986ENST00000550845F8VRV5
ENSG00000088986ENST00000552870F8VXL2

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Intraflagellar transportREACTOMER-HSA-5620924
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BIM and translocation to mitochondriaREACTOMER-HSA-111446
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
COPI-mediated anterograde transportREACTOMER-HSA-6807878
AURKA Activation by TPX2REACTOMER-HSA-8854518
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
230279042012Cortical dynein is critical for proper spindle positioning in human cells.83
204449802010Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
235894912013Systematic dissection of dynein regulators in mitosis.55
156111392005The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation.45
229659102012Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.39
166847792006Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.34
185795192008Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.32
195571732009Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.31
215331212011Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome.29

Citation

Dessen P

DYNLL1 (dynein light chain LC8-type 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45628/dynll1