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DYNLRB1 (dynein light chain roadblock-type 1)

Identity

Alias_namesDNCL2A
dynein
Alias_symbol (synonym)DNLC2A
ROBLD1
Other aliasBITH
BLP
HGNC (Hugo) DYNLRB1
LocusID (NCBI) 83658
Atlas_Id 40345
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 34516384 and ends at 34540958 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNN1 (19p13.2) / DYNLRB1 (20q11.22)CSNK1E (22q13.1) / DYNLRB1 (20q11.22)DYNLRB1 (20q11.22) / ZNF776 (19q13.43)
ITCH (20q11.22) / DYNLRB1 (20q11.22)PHF20 (20q11.22) / DYNLRB1 (20q11.22)RBM8A (1q21.1) / DYNLRB1 (20q11.22)
SKINT1L (1p33) / DYNLRB1 (20q11.22)PHF20 20q11.22 / DYNLRB1 20q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DYNLRB1   15468
Cards
Entrez_Gene (NCBI)DYNLRB1  83658  dynein light chain roadblock-type 1
AliasesBITH; BLP; DNCL2A; DNLC2A; 
ROBLD1
GeneCards (Weizmann)DYNLRB1
Ensembl hg19 (Hinxton)ENSG00000125971 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125971 [Gene_View]  chr20:34516384-34540958 [Contig_View]  DYNLRB1 [Vega]
ICGC DataPortalENSG00000125971
TCGA cBioPortalDYNLRB1
AceView (NCBI)DYNLRB1
Genatlas (Paris)DYNLRB1
WikiGenes83658
SOURCE (Princeton)DYNLRB1
Genetics Home Reference (NIH)DYNLRB1
Genomic and cartography
GoldenPath hg38 (UCSC)DYNLRB1  -     chr20:34516384-34540958 +  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DYNLRB1  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblDYNLRB1 - 20q11.22 [CytoView hg19]  DYNLRB1 - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBIDYNLRB1 [Mapview hg19]  DYNLRB1 [Mapview hg38]
OMIM607167   
Gene and transcription
Genbank (Entrez)AF132750 AF161511 AF165516 AF178431 AK026864
RefSeq transcript (Entrez)NM_001281727 NM_001281728 NM_001281729 NM_001319157 NM_014183 NM_177953
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DYNLRB1
Cluster EST : UnigeneHs.593920 [ NCBI ]
CGAP (NCI)Hs.593920
Alternative Splicing GalleryENSG00000125971
Gene ExpressionDYNLRB1 [ NCBI-GEO ]   DYNLRB1 [ EBI - ARRAY_EXPRESS ]   DYNLRB1 [ SEEK ]   DYNLRB1 [ MEM ]
Gene Expression Viewer (FireBrowse)DYNLRB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83658
GTEX Portal (Tissue expression)DYNLRB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NP97   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NP97  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NP97
Splice isoforms : SwissVarQ9NP97
PhosPhoSitePlusQ9NP97
Domains : Interpro (EBI)DYNLRB1/2    Roadblock/LAMTOR2_dom   
Domain families : Pfam (Sanger)Robl_LC7 (PF03259)   
Domain families : Pfam (NCBI)pfam03259   
Domain families : Smart (EMBL)Robl_LC7 (SM00960)  
Conserved Domain (NCBI)DYNLRB1
DMDM Disease mutations83658
Blocks (Seattle)DYNLRB1
PDB (SRS)1Z09    2B95    2E8J    2HZ5   
PDB (PDBSum)1Z09    2B95    2E8J    2HZ5   
PDB (IMB)1Z09    2B95    2E8J    2HZ5   
PDB (RSDB)1Z09    2B95    2E8J    2HZ5   
Structural Biology KnowledgeBase1Z09    2B95    2E8J    2HZ5   
SCOP (Structural Classification of Proteins)1Z09    2B95    2E8J    2HZ5   
CATH (Classification of proteins structures)1Z09    2B95    2E8J    2HZ5   
SuperfamilyQ9NP97
Human Protein AtlasENSG00000125971
Peptide AtlasQ9NP97
HPRD06203
IPIIPI00643583   IPI00063849   IPI00910924   IPI00412497   
Protein Interaction databases
DIP (DOE-UCLA)Q9NP97
IntAct (EBI)Q9NP97
FunCoupENSG00000125971
BioGRIDDYNLRB1
STRING (EMBL)DYNLRB1
ZODIACDYNLRB1
Ontologies - Pathways
QuickGOQ9NP97
Ontology : AmiGOmicrotubule motor activity  protein binding  cytoplasm  centrosome  cytoplasmic dynein complex  cytoplasmic dynein complex  microtubule  cilium  microtubule-based movement  microtubule-based movement  visual behavior  membrane  dynein complex  intraciliary transport involved in cilium assembly  dynein intermediate chain binding  ciliary tip  
Ontology : EGO-EBImicrotubule motor activity  protein binding  cytoplasm  centrosome  cytoplasmic dynein complex  cytoplasmic dynein complex  microtubule  cilium  microtubule-based movement  microtubule-based movement  visual behavior  membrane  dynein complex  intraciliary transport involved in cilium assembly  dynein intermediate chain binding  ciliary tip  
NDEx NetworkDYNLRB1
Atlas of Cancer Signalling NetworkDYNLRB1
Wikipedia pathwaysDYNLRB1
Orthology - Evolution
OrthoDB83658
GeneTree (enSembl)ENSG00000125971
Phylogenetic Trees/Animal Genes : TreeFamDYNLRB1
HOVERGENQ9NP97
HOGENOMQ9NP97
Homologs : HomoloGeneDYNLRB1
Homology/Alignments : Family Browser (UCSC)DYNLRB1
Gene fusions - Rearrangements
Fusion : MitelmanCSNK1E/DYNLRB1 [22q13.1/20q11.22]  [t(20;22)(q11;q13)]  
Fusion : MitelmanPHF20/DYNLRB1 [20q11.22/20q11.22]  [t(20;20)(q11;q11)]  
Fusion: TCGAPHF20 20q11.22 DYNLRB1 20q11.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYNLRB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYNLRB1
dbVarDYNLRB1
ClinVarDYNLRB1
1000_GenomesDYNLRB1 
Exome Variant ServerDYNLRB1
ExAC (Exome Aggregation Consortium)DYNLRB1 (select the gene name)
Genetic variants : HAPMAP83658
Genomic Variants (DGV)DYNLRB1 [DGVbeta]
DECIPHERDYNLRB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDYNLRB1 
Mutations
ICGC Data PortalDYNLRB1 
TCGA Data PortalDYNLRB1 
Broad Tumor PortalDYNLRB1
OASIS PortalDYNLRB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYNLRB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDYNLRB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DYNLRB1
DgiDB (Drug Gene Interaction Database)DYNLRB1
DoCM (Curated mutations)DYNLRB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYNLRB1 (select a term)
intoGenDYNLRB1
Cancer3DDYNLRB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607167   
Orphanet
MedgenDYNLRB1
Genetic Testing Registry DYNLRB1
NextProtQ9NP97 [Medical]
TSGene83658
GENETestsDYNLRB1
Target ValidationDYNLRB1
Huge Navigator DYNLRB1 [HugePedia]
snp3D : Map Gene to Disease83658
BioCentury BCIQDYNLRB1
ClinGenDYNLRB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83658
Chemical/Pharm GKB GenePA27436
Clinical trialDYNLRB1
Miscellaneous
canSAR (ICR)DYNLRB1 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYNLRB1
EVEXDYNLRB1
GoPubMedDYNLRB1
iHOPDYNLRB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:31:58 CEST 2017

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