DYNLRB1 (dynein light chain roadblock-type 1)

2003-02-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
BITH,BLP,DNCL2A,DNLC2A,ROBLD1
FUSION GENES

Other Information

Locus ID:

NCBI: 83658
MIM: 607167
HGNC: 15468
Ensembl: ENSG00000125971

Variants:

dbSNP: 83658
ClinVar: 83658
TCGA: ENSG00000125971
COSMIC: DYNLRB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125971ENST00000300469Q9NP97
ENSG00000125971ENST00000357156Q9NP97
ENSG00000125971ENST00000374846B1AKR6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180447442008Rab6 family proteins interact with the dynein light chain protein DYNLRB1.28
197113522009Requirement of a dynein light chain in TGFbeta/Smad3 signaling.20
195712322009Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier.12
226375792012The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.8
167780972006Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers.5
237553072013Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.5
230796222012Role of km23-1 in RhoA/actin-based cell migration.4
233334992013Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects.4
169709172006Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74.3
175560762007km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers.2

Citation

Dessen P

DYNLRB1 (dynein light chain roadblock-type 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40345/dynlrb1