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DYNLT1 (dynein light chain Tctex-type 1)

Identity

Other aliasCW-1
TCTEL1
tctex-1
HGNC (Hugo) DYNLT1
LocusID (NCBI) 6993
Atlas_Id 57209
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 158636475 and ends at 158644786 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DYNLT1 (6q25.3) / USP15 (12q14.1)ELL3 (15q15.3) / DYNLT1 (6q25.3)GCA (2q24.2) / DYNLT1 (6q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DYNLT1   11697
Cards
Entrez_Gene (NCBI)DYNLT1  6993  dynein light chain Tctex-type 1
AliasesCW-1; TCTEL1; tctex-1
GeneCards (Weizmann)DYNLT1
Ensembl hg19 (Hinxton)ENSG00000146425 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146425 [Gene_View]  ENSG00000146425 [Sequence]  chr6:158636475-158644786 [Contig_View]  DYNLT1 [Vega]
ICGC DataPortalENSG00000146425
TCGA cBioPortalDYNLT1
AceView (NCBI)DYNLT1
Genatlas (Paris)DYNLT1
WikiGenes6993
SOURCE (Princeton)DYNLT1
Genetics Home Reference (NIH)DYNLT1
Genomic and cartography
GoldenPath hg38 (UCSC)DYNLT1  -     chr6:158636475-158644786 -  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DYNLT1  -     6q25.3   [Description]    (hg19-Feb_2009)
EnsemblDYNLT1 - 6q25.3 [CytoView hg19]  DYNLT1 - 6q25.3 [CytoView hg38]
Mapping of homologs : NCBIDYNLT1 [Mapview hg19]  DYNLT1 [Mapview hg38]
OMIM601554   
Gene and transcription
Genbank (Entrez)AK026669 AK315601 BC029412 BC105588 BU675683
RefSeq transcript (Entrez)NM_001291602 NM_001291603 NM_006519
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DYNLT1
Cluster EST : UnigeneHs.445999 [ NCBI ]
CGAP (NCI)Hs.445999
Alternative Splicing GalleryENSG00000146425
Gene ExpressionDYNLT1 [ NCBI-GEO ]   DYNLT1 [ EBI - ARRAY_EXPRESS ]   DYNLT1 [ SEEK ]   DYNLT1 [ MEM ]
Gene Expression Viewer (FireBrowse)DYNLT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6993
GTEX Portal (Tissue expression)DYNLT1
Human Protein AtlasENSG00000146425-DYNLT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63172   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63172  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63172
Splice isoforms : SwissVarP63172
PhosPhoSitePlusP63172
Domains : Interpro (EBI)Tctex    Tctex-1-like_sf   
Domain families : Pfam (Sanger)Tctex-1 (PF03645)   
Domain families : Pfam (NCBI)pfam03645   
Conserved Domain (NCBI)DYNLT1
DMDM Disease mutations6993
Blocks (Seattle)DYNLT1
PDB (SRS)5JPW   
PDB (PDBSum)5JPW   
PDB (IMB)5JPW   
PDB (RSDB)5JPW   
Structural Biology KnowledgeBase5JPW   
SCOP (Structural Classification of Proteins)5JPW   
CATH (Classification of proteins structures)5JPW   
SuperfamilyP63172
Human Protein Atlas [tissue]ENSG00000146425-DYNLT1 [tissue]
Peptide AtlasP63172
IPIIPI00019495   IPI00478770   IPI00479503   
Protein Interaction databases
DIP (DOE-UCLA)P63172
IntAct (EBI)P63172
FunCoupENSG00000146425
BioGRIDDYNLT1
STRING (EMBL)DYNLT1
ZODIACDYNLT1
Ontologies - Pathways
QuickGOP63172
Ontology : AmiGOestablishment of mitotic spindle orientation  motor activity  protein binding  extracellular region  mitochondrion  Golgi apparatus  spindle  cytoplasmic dynein complex  cytoplasmic dynein complex  cytoplasmic microtubule  protein C-terminus binding  regulation of G protein-coupled receptor signaling pathway  positive regulation of neuron projection development  dendrite development  intracellular transport of viral protein in host cell  lamellipodium  secretory granule lumen  positive regulation of Rac protein signal transduction  negative regulation of mitochondrial membrane permeability  identical protein binding  neuronal cell body  regulation of GTPase activity  neutrophil degranulation  host cell  axonal growth cone  viral entry into host cell  neuron projection morphogenesis  negative regulation of neurogenesis  cell division  regulation of cytoskeleton organization  negative regulation of cell death  axon development  microtubule-dependent intracellular transport of viral material towards nucleus  secretory vesicle  ficolin-1-rich granule lumen  
Ontology : EGO-EBIestablishment of mitotic spindle orientation  motor activity  protein binding  extracellular region  mitochondrion  Golgi apparatus  spindle  cytoplasmic dynein complex  cytoplasmic dynein complex  cytoplasmic microtubule  protein C-terminus binding  regulation of G protein-coupled receptor signaling pathway  positive regulation of neuron projection development  dendrite development  intracellular transport of viral protein in host cell  lamellipodium  secretory granule lumen  positive regulation of Rac protein signal transduction  negative regulation of mitochondrial membrane permeability  identical protein binding  neuronal cell body  regulation of GTPase activity  neutrophil degranulation  host cell  axonal growth cone  viral entry into host cell  neuron projection morphogenesis  negative regulation of neurogenesis  cell division  regulation of cytoskeleton organization  negative regulation of cell death  axon development  microtubule-dependent intracellular transport of viral material towards nucleus  secretory vesicle  ficolin-1-rich granule lumen  
NDEx NetworkDYNLT1
Atlas of Cancer Signalling NetworkDYNLT1
Wikipedia pathwaysDYNLT1
Orthology - Evolution
OrthoDB6993
GeneTree (enSembl)ENSG00000146425
Phylogenetic Trees/Animal Genes : TreeFamDYNLT1
HOVERGENP63172
HOGENOMP63172
Homologs : HomoloGeneDYNLT1
Homology/Alignments : Family Browser (UCSC)DYNLT1
Gene fusions - Rearrangements
Fusion : QuiverDYNLT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYNLT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYNLT1
dbVarDYNLT1
ClinVarDYNLT1
1000_GenomesDYNLT1 
Exome Variant ServerDYNLT1
ExAC (Exome Aggregation Consortium)ENSG00000146425
GNOMAD BrowserENSG00000146425
Varsome BrowserDYNLT1
Genetic variants : HAPMAP6993
Genomic Variants (DGV)DYNLT1 [DGVbeta]
DECIPHERDYNLT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDYNLT1 
Mutations
ICGC Data PortalDYNLT1 
TCGA Data PortalDYNLT1 
Broad Tumor PortalDYNLT1
OASIS PortalDYNLT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYNLT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDYNLT1
BioMutasearch DYNLT1
DgiDB (Drug Gene Interaction Database)DYNLT1
DoCM (Curated mutations)DYNLT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYNLT1 (select a term)
intoGenDYNLT1
Cancer3DDYNLT1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601554   
Orphanet
DisGeNETDYNLT1
MedgenDYNLT1
Genetic Testing Registry DYNLT1
NextProtP63172 [Medical]
TSGene6993
GENETestsDYNLT1
Target ValidationDYNLT1
Huge Navigator DYNLT1 [HugePedia]
snp3D : Map Gene to Disease6993
BioCentury BCIQDYNLT1
ClinGenDYNLT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6993
Chemical/Pharm GKB GenePA36416
Clinical trialDYNLT1
Miscellaneous
canSAR (ICR)DYNLT1 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYNLT1
EVEXDYNLT1
GoPubMedDYNLT1
iHOPDYNLT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:03:39 CET 2018

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