Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2)

Identity

Alias_namesdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Other alias-
HGNC (Hugo) DYRK2
LocusID (NCBI) 8445
Atlas_Id 43236
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 67648732 and ends at 67662664 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DYRK2 (12q15) / DYRK2 (12q15)HMGA2 (12q14.3) / DYRK2 (12q15)TUBB2B (6p25.2) / DYRK2 (12q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(q14;q15) HMGA2/DYRK2


External links

Nomenclature
HGNC (Hugo)DYRK2   3093
Cards
Entrez_Gene (NCBI)DYRK2  8445  dual specificity tyrosine phosphorylation regulated kinase 2
Aliases
GeneCards (Weizmann)DYRK2
Ensembl hg19 (Hinxton)ENSG00000127334 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127334 [Gene_View]  ENSG00000127334 [Sequence]  chr12:67648732-67662664 [Contig_View]  DYRK2 [Vega]
ICGC DataPortalENSG00000127334
TCGA cBioPortalDYRK2
AceView (NCBI)DYRK2
Genatlas (Paris)DYRK2
WikiGenes8445
SOURCE (Princeton)DYRK2
Genetics Home Reference (NIH)DYRK2
Genomic and cartography
GoldenPath hg38 (UCSC)DYRK2  -     chr12:67648732-67662664 +  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DYRK2  -     12q15   [Description]    (hg19-Feb_2009)
EnsemblDYRK2 - 12q15 [CytoView hg19]  DYRK2 - 12q15 [CytoView hg38]
Mapping of homologs : NCBIDYRK2 [Mapview hg19]  DYRK2 [Mapview hg38]
OMIM603496   
Gene and transcription
Genbank (Entrez)AK024870 AK025018 AK313937 AL832817 BC005809
RefSeq transcript (Entrez)NM_003583 NM_006482
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DYRK2
Cluster EST : UnigeneHs.173135 [ NCBI ]
CGAP (NCI)Hs.173135
Alternative Splicing GalleryENSG00000127334
Gene ExpressionDYRK2 [ NCBI-GEO ]   DYRK2 [ EBI - ARRAY_EXPRESS ]   DYRK2 [ SEEK ]   DYRK2 [ MEM ]
Gene Expression Viewer (FireBrowse)DYRK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8445
GTEX Portal (Tissue expression)DYRK2
Human Protein AtlasENSG00000127334-DYRK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92630   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92630  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92630
Splice isoforms : SwissVarQ92630
PhosPhoSitePlusQ92630
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)DYRK2
DMDM Disease mutations8445
Blocks (Seattle)DYRK2
PDB (SRS)3K2L    3KVW    4AZF    5LXC    5LXD   
PDB (PDBSum)3K2L    3KVW    4AZF    5LXC    5LXD   
PDB (IMB)3K2L    3KVW    4AZF    5LXC    5LXD   
PDB (RSDB)3K2L    3KVW    4AZF    5LXC    5LXD   
Structural Biology KnowledgeBase3K2L    3KVW    4AZF    5LXC    5LXD   
SCOP (Structural Classification of Proteins)3K2L    3KVW    4AZF    5LXC    5LXD   
CATH (Classification of proteins structures)3K2L    3KVW    4AZF    5LXC    5LXD   
SuperfamilyQ92630
Human Protein Atlas [tissue]ENSG00000127334-DYRK2 [tissue]
Peptide AtlasQ92630
HPRD04606
IPIIPI00304942   IPI00022521   IPI01010889   IPI01014583   IPI01015024   
Protein Interaction databases
DIP (DOE-UCLA)Q92630
IntAct (EBI)Q92630
FunCoupENSG00000127334
BioGRIDDYRK2
STRING (EMBL)DYRK2
ZODIACDYRK2
Ontologies - Pathways
QuickGOQ92630
Ontology : AmiGOubiquitin ligase complex  magnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  cellular response to DNA damage stimulus  smoothened signaling pathway  peptidyl-tyrosine phosphorylation  manganese ion binding  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of glycogen biosynthetic process  negative regulation of calcineurin-NFAT signaling cascade  regulation of signal transduction by p53 class mediator  ribonucleoprotein complex  
Ontology : EGO-EBIubiquitin ligase complex  magnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  cellular response to DNA damage stimulus  smoothened signaling pathway  peptidyl-tyrosine phosphorylation  manganese ion binding  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of glycogen biosynthetic process  negative regulation of calcineurin-NFAT signaling cascade  regulation of signal transduction by p53 class mediator  ribonucleoprotein complex  
NDEx NetworkDYRK2
Atlas of Cancer Signalling NetworkDYRK2
Wikipedia pathwaysDYRK2
Orthology - Evolution
OrthoDB8445
GeneTree (enSembl)ENSG00000127334
Phylogenetic Trees/Animal Genes : TreeFamDYRK2
HOVERGENQ92630
HOGENOMQ92630
Homologs : HomoloGeneDYRK2
Homology/Alignments : Family Browser (UCSC)DYRK2
Gene fusions - Rearrangements
Fusion : QuiverDYRK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYRK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYRK2
dbVarDYRK2
ClinVarDYRK2
1000_GenomesDYRK2 
Exome Variant ServerDYRK2
ExAC (Exome Aggregation Consortium)ENSG00000127334
GNOMAD BrowserENSG00000127334
Varsome BrowserDYRK2
Genetic variants : HAPMAP8445
Genomic Variants (DGV)DYRK2 [DGVbeta]
DECIPHERDYRK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDYRK2 
Mutations
ICGC Data PortalDYRK2 
TCGA Data PortalDYRK2 
Broad Tumor PortalDYRK2
OASIS PortalDYRK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYRK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDYRK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DYRK2
DgiDB (Drug Gene Interaction Database)DYRK2
DoCM (Curated mutations)DYRK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYRK2 (select a term)
intoGenDYRK2
Cancer3DDYRK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603496   
Orphanet
DisGeNETDYRK2
MedgenDYRK2
Genetic Testing Registry DYRK2
NextProtQ92630 [Medical]
TSGene8445
GENETestsDYRK2
Target ValidationDYRK2
Huge Navigator DYRK2 [HugePedia]
snp3D : Map Gene to Disease8445
BioCentury BCIQDYRK2
ClinGenDYRK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8445
Chemical/Pharm GKB GenePA27550
Clinical trialDYRK2
Miscellaneous
canSAR (ICR)DYRK2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYRK2
EVEXDYRK2
GoPubMedDYRK2
iHOPDYRK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:03:40 CET 2018

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