| Nomenclature |
|---|
| HGNC (Hugo) | E2F2 3114 |
| Cards |
|---|
| Entrez_Gene (NCBI) | E2F2 1870 E2F transcription factor 2 |
| Aliases | E2F-2 |
| GeneCards (Weizmann) | E2F2 |
| Ensembl hg19 (Hinxton) | ENSG00000007968 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000007968 [Gene_View] ENSG00000007968 [Sequence] chr1:23506428-23531220 [Contig_View] E2F2 [Vega] |
| ICGC DataPortal | ENSG00000007968 |
| TCGA cBioPortal | E2F2 |
| AceView (NCBI) | E2F2 |
| Genatlas (Paris) | E2F2 |
| WikiGenes | 1870 |
| SOURCE (Princeton) | E2F2 |
| Genetics Home Reference (NIH) | E2F2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | E2F2 - chr1:23506428-23531220 - 1p36.12 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | E2F2 - 1p36.12 [Description] (hg19-Feb_2009) |
E2F2 - 1p36.12 [CytoView hg19] E2F2 - 1p36.12 [CytoView hg38] |
| Mapping of homologs : NCBI | E2F2 [Mapview hg19] E2F2 [Mapview hg38] |
| OMIM | 600426 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF086395 AK092799 AK313939 BC007609 BC053676 |
| RefSeq transcript (Entrez) | NM_004091 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | E2F2 |
| Cluster EST : Unigene | Hs.194333 [ NCBI ] |
| CGAP (NCI) | Hs.194333 |
| Alternative Splicing Gallery | ENSG00000007968 |
| Gene Expression | E2F2 [ NCBI-GEO ] E2F2 [ EBI - ARRAY_EXPRESS ]
E2F2 [ SEEK ] E2F2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | E2F2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1870 |
| GTEX Portal (Tissue expression) | E2F2 |
| Human Protein Atlas | ENSG00000007968-E2F2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q14209 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q14209 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q14209 |
| Splice isoforms : SwissVar | Q14209 |
| PhosPhoSitePlus | Q14209 |
| Domains : Interpro (EBI) | E2F E2F-DP_heterodim E2F_CC-MB E2F_WHTH_DNA-bd_dom WH-like_DNA-bd_sf WH_DNA-bd_sf |
| Domain families : Pfam (Sanger) | E2F_CC-MB (PF16421) E2F_TDP (PF02319) |
| Domain families : Pfam (NCBI) | pfam16421 pfam02319 |
| Domain families : Smart (EMBL) | E2F_TDP (SM01372) |
| Conserved Domain (NCBI) | E2F2 |
| DMDM Disease mutations | 1870 |
| Blocks (Seattle) | E2F2 |
| PDB (RSDB) | 1N4M |
| PDB Europe | 1N4M |
| PDB (PDBSum) | 1N4M |
| PDB (IMB) | 1N4M |
| Structural Biology KnowledgeBase | 1N4M |
| SCOP (Structural Classification of Proteins) | 1N4M |
| CATH (Classification of proteins structures) | 1N4M |
| Superfamily | Q14209 |
| Human Protein Atlas [tissue] | ENSG00000007968-E2F2 [tissue] |
| Peptide Atlas | Q14209 |
| HPRD | 02692 |
| IPI | IPI00290548 IPI00063570 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q14209 |
| IntAct (EBI) | Q14209 |
| FunCoup | ENSG00000007968 |
| BioGRID | E2F2 |
| STRING (EMBL) | E2F2 |
| ZODIAC | E2F2 |
| Ontologies - Pathways |
|---|
| QuickGO | Q14209 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific proximal promoter sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleoplasm transcription initiation from RNA polymerase II promoter cell cycle transcription factor binding transcription factor binding sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein dimerization activity regulation of cell cycle intrinsic apoptotic signaling pathway by p53 class mediator RNA polymerase II transcription factor complex RNA polymerase II transcription factor complex negative regulation of sprouting angiogenesis lens fiber cell apoptotic process |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific proximal promoter sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleoplasm transcription initiation from RNA polymerase II promoter cell cycle transcription factor binding transcription factor binding sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein dimerization activity regulation of cell cycle intrinsic apoptotic signaling pathway by p53 class mediator RNA polymerase II transcription factor complex RNA polymerase II transcription factor complex negative regulation of sprouting angiogenesis lens fiber cell apoptotic process |
| Pathways : KEGG | Cell cycle Hepatitis B HTLV-I infection Pathways in cancer MicroRNAs in cancer Pancreatic cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer |
| NDEx Network | E2F2 |
| Atlas of Cancer Signalling Network | E2F2 |
| Wikipedia pathways | E2F2 |
| Orthology - Evolution |
|---|
| OrthoDB | 1870 |
| GeneTree (enSembl) | ENSG00000007968 |
| Phylogenetic Trees/Animal Genes : TreeFam | E2F2 |
| HOGENOM | Q14209 |
| Homologs : HomoloGene | E2F2 |
| Homology/Alignments : Family Browser (UCSC) | E2F2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | E2F2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | E2F2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | E2F2 |
| dbVar | E2F2 |
| ClinVar | E2F2 |
| 1000_Genomes | E2F2 |
| Exome Variant Server | E2F2 |
| ExAC (Exome Aggregation Consortium) | ENSG00000007968 |
| GNOMAD Browser | ENSG00000007968 |
| Varsome Browser | E2F2 |
| Genetic variants : HAPMAP | 1870 |
| Genomic Variants (DGV) | E2F2 [DGVbeta] |
| DECIPHER | E2F2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | E2F2 |
| Mutations |
|---|
| ICGC Data Portal | E2F2 |
| TCGA Data Portal | E2F2 |
| Broad Tumor Portal | E2F2 |
| OASIS Portal | E2F2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | E2F2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | E2F2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search E2F2 |
| DgiDB (Drug Gene Interaction Database) | E2F2 |
| DoCM (Curated mutations) | E2F2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | E2F2 (select a term) |
| intoGen | E2F2 |
| Cancer3D | E2F2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600426 |
| Orphanet | |
| DisGeNET | E2F2 |
| Medgen | E2F2 |
| Genetic Testing Registry | E2F2
|
| NextProt | Q14209 [Medical] |
| TSGene | 1870 |
| GENETests | E2F2 |
| Target Validation | E2F2 |
| Huge Navigator |
E2F2 [HugePedia] |
| snp3D : Map Gene to Disease | 1870 |
| BioCentury BCIQ | E2F2 |
| ClinGen | E2F2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1870 |
| Chemical/Pharm GKB Gene | PA27572 |
| Clinical trial | E2F2 |
| Miscellaneous |
|---|
| canSAR (ICR) | E2F2 (select the gene name) |
| DataMed Index | E2F2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 96 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | E2F2 |
| EVEX | E2F2 |
| GoPubMed | E2F2 |
| iHOP | E2F2 |
