Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

EARS2 (glutamyl-tRNA synthetase 2, mitochondrial)

Identity

Alias (NCBI)COXPD12
MSE1
gluRS
mtGlnRS
HGNC (Hugo) EARS2
HGNC Alias symbKIAA1970
MSE1
HGNC Alias nameglutamate tRNA ligase 2, mitochondrial
HGNC Previous nameglutamyl-tRNA synthetase 2, mitochondrial (putative)
LocusID (NCBI) 124454
Atlas_Id 62704
Location 16p12.2  [Link to chromosome band 16p12]
Location_base_pair Starts at 23525020 and ends at 23557375 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EARS2 (16p12.2) / VMP1 (17q23.1)HMGB2 (4q34.1) / EARS2 (16p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EARS2   29419
Cards
Entrez_Gene (NCBI)EARS2    glutamyl-tRNA synthetase 2, mitochondrial
AliasesCOXPD12; MSE1; gluRS; mtGlnRS
GeneCards (Weizmann)EARS2
Ensembl hg19 (Hinxton)ENSG00000103356 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103356 [Gene_View]  ENSG00000103356 [Sequence]  chr16:23525020-23557375 [Contig_View]  EARS2 [Vega]
ICGC DataPortalENSG00000103356
TCGA cBioPortalEARS2
AceView (NCBI)EARS2
Genatlas (Paris)EARS2
SOURCE (Princeton)EARS2
Genetics Home Reference (NIH)EARS2
Genomic and cartography
GoldenPath hg38 (UCSC)EARS2  -     chr16:23525020-23557375 -  16p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EARS2  -     16p12.2   [Description]    (hg19-Feb_2009)
GoldenPathEARS2 - 16p12.2 [CytoView hg19]  EARS2 - 16p12.2 [CytoView hg38]
ImmunoBaseENSG00000103356
Genome Data Viewer NCBIEARS2 [Mapview hg19]  
OMIM612799   614924   
Gene and transcription
Genbank (Entrez)AB075850 AF088053 AK095998 AL832489 BC020592
RefSeq transcript (Entrez)NM_001083614 NM_001308211
Consensus coding sequences : CCDS (NCBI)EARS2
Gene ExpressionEARS2 [ NCBI-GEO ]   EARS2 [ EBI - ARRAY_EXPRESS ]   EARS2 [ SEEK ]   EARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)EARS2 [ Firebrowse - Broad ]
GenevisibleExpression of EARS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)124454
GTEX Portal (Tissue expression)EARS2
Human Protein AtlasENSG00000103356-EARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5JPH6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5JPH6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5JPH6
Catalytic activity : Enzyme6.1.1.17 [ Enzyme-Expasy ]   6.1.1.176.1.1.17 [ IntEnz-EBI ]   6.1.1.17 [ BRENDA ]   6.1.1.17 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ5JPH6
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_codon-bd    aa-tRNA-synth_I_codon-bd_sub2    aa-tRNA-synth_I_CS    Glu-tRNA-ligase_bac/mito    Glu/Gln-tRNA-synth    Glu/Gln-tRNA-synth_Ib_cat-dom    GluRS_core    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)tRNA-synt_1c (PF00749)   
Domain families : Pfam (NCBI)pfam00749   
Conserved Domain (NCBI)EARS2
SuperfamilyQ5JPH6
AlphaFold pdb e-kbQ5JPH6   
Human Protein Atlas [tissue]ENSG00000103356-EARS2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q5JPH6
IntAct (EBI)Q5JPH6
BioGRIDEARS2
STRING (EMBL)EARS2
ZODIACEARS2
Ontologies - Pathways
QuickGOQ5JPH6
Ontology : AmiGOtRNA binding  glutamate-tRNA ligase activity  glutamate-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  glutamyl-tRNA aminoacylation  glutamyl-tRNA aminoacylation  zinc ion binding  glutamate-tRNA(Gln) ligase activity  tRNA aminoacylation for mitochondrial protein translation  
Ontology : EGO-EBItRNA binding  glutamate-tRNA ligase activity  glutamate-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  glutamyl-tRNA aminoacylation  glutamyl-tRNA aminoacylation  zinc ion binding  glutamate-tRNA(Gln) ligase activity  tRNA aminoacylation for mitochondrial protein translation  
Pathways : KEGGGlutamate metabolism    Aminoacyl-tRNA biosynthesis    Porphyrin and chlorophyll metabolism   
NDEx NetworkEARS2
Atlas of Cancer Signalling NetworkEARS2
Wikipedia pathwaysEARS2
Orthology - Evolution
OrthoDB124454
GeneTree (enSembl)ENSG00000103356
Phylogenetic Trees/Animal Genes : TreeFamEARS2
Homologs : HomoloGeneEARS2
Homology/Alignments : Family Browser (UCSC)EARS2
Gene fusions - Rearrangements
Fusion : QuiverEARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EARS2
dbVarEARS2
ClinVarEARS2
MonarchEARS2
1000_GenomesEARS2 
Exome Variant ServerEARS2
GNOMAD BrowserENSG00000103356
Varsome BrowserEARS2
ACMGEARS2 variants
VarityQ5JPH6
Genomic Variants (DGV)EARS2 [DGVbeta]
DECIPHEREARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEARS2 
Mutations
ICGC Data PortalEARS2 
TCGA Data PortalEARS2 
Broad Tumor PortalEARS2
OASIS PortalEARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEARS2
Mutations and Diseases : HGMDEARS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEARS2
DgiDB (Drug Gene Interaction Database)EARS2
DoCM (Curated mutations)EARS2
CIViC (Clinical Interpretations of Variants in Cancer)EARS2
Cancer3DEARS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612799    614924   
Orphanet21475   
DisGeNETEARS2
MedgenEARS2
Genetic Testing Registry EARS2
NextProtQ5JPH6 [Medical]
GENETestsEARS2
Target ValidationEARS2
Huge Navigator EARS2 [HugePedia]
ClinGenEARS2
Clinical trials, drugs, therapy
MyCancerGenomeEARS2
Protein Interactions : CTDEARS2
Pharm GKB GenePA144596439
PharosQ5JPH6
Clinical trialEARS2
Miscellaneous
canSAR (ICR)EARS2
HarmonizomeEARS2
DataMed IndexEARS2
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:48:34 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.