ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator)

2016-10-01  

Identity

HGNC
ECSCR
LOCATION
5q31.2
LOCUSID
641700
ALIAS
ARIA,ECSM2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 641700
MIM: 615736
HGNC: 35454
Ensembl: ENSG00000249751

Variants:

dbSNP: 641700
ClinVar: 641700
TCGA: ENSG00000249751
COSMIC: ECSCR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000249751ENST00000618155Q19T08

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
192407912009Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.24
185565732008ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis.17
194168532009Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2.13
192677802009Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling.9
217205472011Endothelial cell-specific molecule 2 (ECSM2) localizes to cell-cell junctions and modulates bFGF-directed cell migration via the ERK-FAK pathway.9
269560512016Biomarkers of evasive resistance predict disease progression in cancer patients treated with antiangiogenic therapies.8
233931312013Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.7
231475652012Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis.0

Citation

Dessen P

ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56251/ecscr