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ECT2L (epithelial cell transforming 2 like)

Identity

Alias_namesC6orf91
chromosome 6 open reading frame 91
epithelial cell transforming sequence 2 oncogene-like
Alias_symbol (synonym)ARHGEF32
FBXO49
LFDH
Other aliasdJ509I19.2
dJ509I19.3
dJ509I19.5
HGNC (Hugo) ECT2L
LocusID (NCBI) 345930
Atlas_Id 40401
Location 6q24.1  [Link to chromosome band 6q24]
Location_base_pair Starts at 138796111 and ends at 138904070 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ECT2L (6q24.1) / ZEB1 (10p11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ECT2L   21118
Cards
Entrez_Gene (NCBI)ECT2L  345930  epithelial cell transforming 2 like
AliasesARHGEF32; C6orf91; FBXO49; LFDH; 
dJ509I19.2; dJ509I19.3; dJ509I19.5
GeneCards (Weizmann)ECT2L
Ensembl hg19 (Hinxton)ENSG00000203734 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000203734 [Gene_View]  ENSG00000203734 [Sequence]  chr6:138796111-138904070 [Contig_View]  ECT2L [Vega]
ICGC DataPortalENSG00000203734
TCGA cBioPortalECT2L
AceView (NCBI)ECT2L
Genatlas (Paris)ECT2L
WikiGenes345930
SOURCE (Princeton)ECT2L
Genetics Home Reference (NIH)ECT2L
Genomic and cartography
GoldenPath hg38 (UCSC)ECT2L  -     chr6:138796111-138904070 +  6q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ECT2L  -     6q24.1   [Description]    (hg19-Feb_2009)
EnsemblECT2L - 6q24.1 [CytoView hg19]  ECT2L - 6q24.1 [CytoView hg38]
Mapping of homologs : NCBIECT2L [Mapview hg19]  ECT2L [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK304425 BC146884 DB221732 DC415949 DC416153
RefSeq transcript (Entrez)NM_001077706 NM_001195037
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ECT2L
Cluster EST : UnigeneHs.660603 [ NCBI ]
CGAP (NCI)Hs.660603
Alternative Splicing GalleryENSG00000203734
Gene ExpressionECT2L [ NCBI-GEO ]   ECT2L [ EBI - ARRAY_EXPRESS ]   ECT2L [ SEEK ]   ECT2L [ MEM ]
Gene Expression Viewer (FireBrowse)ECT2L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)345930
GTEX Portal (Tissue expression)ECT2L
Human Protein AtlasENSG00000203734-ECT2L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ008S8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ008S8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ008S8
Splice isoforms : SwissVarQ008S8
PhosPhoSitePlusQ008S8
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    DUF4347    F-box-like_dom_sf    F-box_dom    PH-like_dom_sf   
Domain families : Pfam (Sanger)DUF4347 (PF14252)    F-box-like (PF12937)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam14252    pfam12937    pfam00621   
Domain families : Smart (EMBL)RhoGEF (SM00325)  
Conserved Domain (NCBI)ECT2L
DMDM Disease mutations345930
Blocks (Seattle)ECT2L
SuperfamilyQ008S8
Human Protein Atlas [tissue]ENSG00000203734-ECT2L [tissue]
Peptide AtlasQ008S8
IPIIPI00247492   IPI00642818   IPI00643329   
Protein Interaction databases
DIP (DOE-UCLA)Q008S8
IntAct (EBI)Q008S8
FunCoupENSG00000203734
BioGRIDECT2L
STRING (EMBL)ECT2L
ZODIACECT2L
Ontologies - Pathways
QuickGOQ008S8
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  regulation of Rho protein signal transduction  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  regulation of Rho protein signal transduction  
NDEx NetworkECT2L
Atlas of Cancer Signalling NetworkECT2L
Wikipedia pathwaysECT2L
Orthology - Evolution
OrthoDB345930
GeneTree (enSembl)ENSG00000203734
Phylogenetic Trees/Animal Genes : TreeFamECT2L
HOVERGENQ008S8
HOGENOMQ008S8
Homologs : HomoloGeneECT2L
Homology/Alignments : Family Browser (UCSC)ECT2L
Gene fusions - Rearrangements
Fusion : QuiverECT2L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerECT2L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ECT2L
dbVarECT2L
ClinVarECT2L
1000_GenomesECT2L 
Exome Variant ServerECT2L
ExAC (Exome Aggregation Consortium)ENSG00000203734
GNOMAD BrowserENSG00000203734
Varsome BrowserECT2L
Genetic variants : HAPMAP345930
Genomic Variants (DGV)ECT2L [DGVbeta]
DECIPHERECT2L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisECT2L 
Mutations
ICGC Data PortalECT2L 
TCGA Data PortalECT2L 
Broad Tumor PortalECT2L
OASIS PortalECT2L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICECT2L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDECT2L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ECT2L
DgiDB (Drug Gene Interaction Database)ECT2L
DoCM (Curated mutations)ECT2L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ECT2L (select a term)
intoGenECT2L
Cancer3DECT2L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETECT2L
MedgenECT2L
Genetic Testing Registry ECT2L
NextProtQ008S8 [Medical]
TSGene345930
GENETestsECT2L
Target ValidationECT2L
Huge Navigator ECT2L [HugePedia]
snp3D : Map Gene to Disease345930
BioCentury BCIQECT2L
ClinGenECT2L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD345930
Chemical/Pharm GKB GenePA134893289
Clinical trialECT2L
Miscellaneous
canSAR (ICR)ECT2L (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineECT2L
EVEXECT2L
GoPubMedECT2L
iHOPECT2L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:20:31 CEST 2018

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