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EDC4 (enhancer of mRNA decapping 4)

Identity

Alias_symbol (synonym)RCD-8
Ge-1
HEDLS
Other aliasGE1
HEDL5
RCD8
HGNC (Hugo) EDC4
LocusID (NCBI) 23644
Atlas_Id 62724
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 67873023 and ends at 67884514 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C11orf68 (11q13.1) / EDC4 (16q22.1)EDC4 (16q22.1) / BRCA1 (17q21.31)EDC4 (16q22.1) / PRPF6 (20q13.33)
NFATC3 (16q22.1) / EDC4 (16q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EDC4   17157
Cards
Entrez_Gene (NCBI)EDC4  23644  enhancer of mRNA decapping 4
AliasesGE1; Ge-1; HEDL5; HEDLS; 
RCD-8; RCD8
GeneCards (Weizmann)EDC4
Ensembl hg19 (Hinxton)ENSG00000038358 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000038358 [Gene_View]  chr16:67873023-67884514 [Contig_View]  EDC4 [Vega]
ICGC DataPortalENSG00000038358
TCGA cBioPortalEDC4
AceView (NCBI)EDC4
Genatlas (Paris)EDC4
WikiGenes23644
SOURCE (Princeton)EDC4
Genetics Home Reference (NIH)EDC4
Genomic and cartography
GoldenPath hg38 (UCSC)EDC4  -     chr16:67873023-67884514 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EDC4  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblEDC4 - 16q22.1 [CytoView hg19]  EDC4 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIEDC4 [Mapview hg19]  EDC4 [Mapview hg38]
OMIM606030   
Gene and transcription
Genbank (Entrez)AI076562 AI631525 AK128582 AK291049 AK302563
RefSeq transcript (Entrez)NM_014329
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EDC4
Cluster EST : UnigeneHs.75682 [ NCBI ]
CGAP (NCI)Hs.75682
Alternative Splicing GalleryENSG00000038358
Gene ExpressionEDC4 [ NCBI-GEO ]   EDC4 [ EBI - ARRAY_EXPRESS ]   EDC4 [ SEEK ]   EDC4 [ MEM ]
Gene Expression Viewer (FireBrowse)EDC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23644
GTEX Portal (Tissue expression)EDC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P2E9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P2E9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P2E9
Splice isoforms : SwissVarQ6P2E9
PhosPhoSitePlusQ6P2E9
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)EDC4_WD40    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)Ge1_WD40 (PF16529)   
Domain families : Pfam (NCBI)pfam16529   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)EDC4
DMDM Disease mutations23644
Blocks (Seattle)EDC4
SuperfamilyQ6P2E9
Human Protein AtlasENSG00000038358
Peptide AtlasQ6P2E9
HPRD06911
IPIIPI00376317   IPI00641449   IPI01013875   
Protein Interaction databases
DIP (DOE-UCLA)Q6P2E9
IntAct (EBI)Q6P2E9
FunCoupENSG00000038358
BioGRIDEDC4
STRING (EMBL)EDC4
ZODIACEDC4
Ontologies - Pathways
QuickGOQ6P2E9
Ontology : AmiGOP-body  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  biological_process  membrane  deadenylation-independent decapping of nuclear-transcribed mRNA  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  
Ontology : EGO-EBIP-body  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  biological_process  membrane  deadenylation-independent decapping of nuclear-transcribed mRNA  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  
Pathways : KEGGRNA degradation   
NDEx NetworkEDC4
Atlas of Cancer Signalling NetworkEDC4
Wikipedia pathwaysEDC4
Orthology - Evolution
OrthoDB23644
GeneTree (enSembl)ENSG00000038358
Phylogenetic Trees/Animal Genes : TreeFamEDC4
HOVERGENQ6P2E9
HOGENOMQ6P2E9
Homologs : HomoloGeneEDC4
Homology/Alignments : Family Browser (UCSC)EDC4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEDC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EDC4
dbVarEDC4
ClinVarEDC4
1000_GenomesEDC4 
Exome Variant ServerEDC4
ExAC (Exome Aggregation Consortium)EDC4 (select the gene name)
Genetic variants : HAPMAP23644
Genomic Variants (DGV)EDC4 [DGVbeta]
DECIPHEREDC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEDC4 
Mutations
ICGC Data PortalEDC4 
TCGA Data PortalEDC4 
Broad Tumor PortalEDC4
OASIS PortalEDC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEDC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEDC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EDC4
DgiDB (Drug Gene Interaction Database)EDC4
DoCM (Curated mutations)EDC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EDC4 (select a term)
intoGenEDC4
Cancer3DEDC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606030   
Orphanet
MedgenEDC4
Genetic Testing Registry EDC4
NextProtQ6P2E9 [Medical]
TSGene23644
GENETestsEDC4
Target ValidationEDC4
Huge Navigator EDC4 [HugePedia]
snp3D : Map Gene to Disease23644
BioCentury BCIQEDC4
ClinGenEDC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23644
Chemical/Pharm GKB GenePA145148958
Clinical trialEDC4
Miscellaneous
canSAR (ICR)EDC4 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEDC4
EVEXEDC4
GoPubMedEDC4
iHOPEDC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:46:45 CEST 2017

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