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EDEM1 (ER degradation enhancer, mannosidase alpha-like 1)

Identity

Other namesEDEM
HGNC (Hugo) EDEM1
LocusID (NCBI) 9695
Location 3p26.1
Location_base_pair Starts at 5229359 and ends at 5261650 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EDEM1   18967
Entrez_Gene (NCBI)EDEM1  9695  ER degradation enhancer, mannosidase alpha-like 1
Cards
GeneCards (Weizmann)EDEM1
Ensembl (Hinxton)ENSG00000134109 [Gene_View]  chr3:5229359-5261650 [Contig_View]  EDEM1 [Vega]
AceView (NCBI)EDEM1
Genatlas (Paris)EDEM1
SOURCE (Stanford)NM_014674
Genomic and cartography
GoldenPath (UCSC)EDEM1  -  3p26.1   chr3:5229359-5261650 +  3p26.1   [Description]    (hg19-Feb_2009)
EnsemblEDEM1 - 3p26.1 [CytoView]
Mapping of homologs : NCBIEDEM1 [Mapview]
OMIM607673   
Gene and transcription
Genbank (Entrez)AK292643 AK298511 AK302065 BC019088 CN364698
RefSeq transcript (SRS)NM_014674
RefSeq transcript (Entrez)NM_014674
RefSeq genomic (SRS)AC_000135 NC_000003 NC_018914 NT_022517 NW_001838876 NW_004078011
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NT_022517 NW_001838876 NW_004078011
Consensus coding sequences : CCDS (NCBI)EDEM1
Cluster EST : UnigeneHs.224616 [ SRS ] Hs.224616 [ NCBI ]
CGAP (NCI)Hs.224616
Alternative Splicing : Fast-db (Paris)GSHG0020550
Alternative Splicing GalleryENSG00000134109
Gene ExpressionEDEM1 [ NCBI-GEO ]   EDEM1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92611 (SRS) Q92611 (Uniprot)
NextProtQ92611
With graphics : InterProQ92611
Splice isoforms : SwissVarQ92611(Swissvar)
Domains : Interpro (SRS)Glyco_hydro_47   
Domains : Interpro (EBI)Glyco_hydro_47   
Related proteins : CluSTrQ92611
Domain families : Pfam (SRS)Glyco_hydro_47 (PF01532)   
Domain families : Pfam (Sanger)Glyco_hydro_47 (PF01532)   
Domain families : Pfam (NCBI)pfam01532   
DMDM9695
Blocks (Seattle)Q92611
Human Protein AtlasENSG00000134109
HPRD09644
IPIIPI00005683   IPI00910568   IPI00305046   IPI00926446   IPI00925811   IPI00926924   
Protein Interaction databases
DIP (DOE-UCLA)Q92611
IntAct (EBI)Q92611
FunCoupENSG00000134109
REACTOMEEDEM1
Protein Interaction Database9695
BioGRIDEDEM1
InParanoidQ92611
Interologous Interaction database Q92611
IntegromeDBEDEM1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EDEM1
SNP (GeneSNP Utah)EDEM1
SNP : HGBaseEDEM1
Genetic variants : HAPMAPEDEM1
Somatic Mutations in Cancer : COSMICEDEM1 
CONAN: Copy Number AnalysisEDEM1 
Mutations and Diseases : HGMDEDEM1
OMIM607673   
GENETests607673   
Disease Genetic AssociationEDEM1
Huge Navigator EDEM1 [HugePedia]  EDEM1 [HugeCancerGEM]
Genomic VariantsEDEM1  EDEM1 [DGVbeta]
snp3D : Map Gene to Disease9695
General knowledge
Homologs : HomoloGeneEDEM1
Homology/Alignments : Family Browser (UCSC)EDEM1
Phylogenetic Trees/Animal Genes : TreeFamEDEM1
Chemical/Protein Interactions : CTD9695
Chemical/Pharm GKB GenePA128394554
Clinical trialEDEM1
Cancer Resource (Charite)ENSG00000134109
Ontology : AmiGOmannosyl-oligosaccharide 1,2-alpha-mannosidase activity  calcium ion binding  protein binding  endoplasmic reticulum membrane  protein folding  activation of signaling protein activity involved in unfolded protein response  protein N-linked glycosylation via asparagine  integral to endoplasmic reticulum membrane  ER-associated protein catabolic process  endoplasmic reticulum unfolded protein response  post-translational protein modification  cellular protein metabolic process  misfolded protein binding  
Ontology : EGO-EBImannosyl-oligosaccharide 1,2-alpha-mannosidase activity  calcium ion binding  protein binding  endoplasmic reticulum membrane  protein folding  activation of signaling protein activity involved in unfolded protein response  protein N-linked glycosylation via asparagine  integral to endoplasmic reticulum membrane  ER-associated protein catabolic process  endoplasmic reticulum unfolded protein response  post-translational protein modification  cellular protein metabolic process  misfolded protein binding  
Pathways : BIOCARTAER¿associated degradation (ERAD) Pathway [Genes]   
Pathways : KEGGNucleotide sugars metabolismAminosugars metabolism
Other databases
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
PubGeneEDEM1
iHOPEDEM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:33:50 CEST 2013
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