Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2)

Identity

Alias_namesC20orf49
C20orf31
chromosome 20 open reading frame 31
ER degradation enhancer, mannosidase alpha-like 2
Alias_symbol (synonym)FLJ10783
bA4204.1
Other alias
HGNC (Hugo) EDEM2
LocusID (NCBI) 55741
Atlas_Id 62727
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 35115357 and ends at 35147358 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BIRC6 (2p22.3) / EDEM2 (20q11.22)EDEM2 (20q11.22) / CTSS (1q21.3)EDEM2 (20q11.22) / DNAH14 (1q42.12)
EDEM2 (20q11.22) / UQCC1 (20q11.22)MBTPS2 (Xp22.12) / EDEM2 (20q11.22)NAPB (20p11.21) / EDEM2 (20q11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EDEM2   15877
Cards
Entrez_Gene (NCBI)EDEM2  55741  ER degradation enhancing alpha-mannosidase like protein 2
AliasesC20orf31; C20orf49; bA4204.1
GeneCards (Weizmann)EDEM2
Ensembl hg19 (Hinxton)ENSG00000088298 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088298 [Gene_View]  chr20:35115357-35147358 [Contig_View]  EDEM2 [Vega]
ICGC DataPortalENSG00000088298
TCGA cBioPortalEDEM2
AceView (NCBI)EDEM2
Genatlas (Paris)EDEM2
WikiGenes55741
SOURCE (Princeton)EDEM2
Genetics Home Reference (NIH)EDEM2
Genomic and cartography
GoldenPath hg38 (UCSC)EDEM2  -     chr20:35115357-35147358 -  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EDEM2  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblEDEM2 - 20q11.22 [CytoView hg19]  EDEM2 - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBIEDEM2 [Mapview hg19]  EDEM2 [Mapview hg38]
OMIM610302   
Gene and transcription
Genbank (Entrez)AF086313 AI919497 AK001645 AK023931 AK096016
RefSeq transcript (Entrez)NM_001145025 NM_018217
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EDEM2
Cluster EST : UnigeneHs.720177 [ NCBI ]
CGAP (NCI)Hs.720177
Alternative Splicing GalleryENSG00000088298
Gene ExpressionEDEM2 [ NCBI-GEO ]   EDEM2 [ EBI - ARRAY_EXPRESS ]   EDEM2 [ SEEK ]   EDEM2 [ MEM ]
Gene Expression Viewer (FireBrowse)EDEM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55741
GTEX Portal (Tissue expression)EDEM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BV94   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BV94  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BV94
Splice isoforms : SwissVarQ9BV94
PhosPhoSitePlusQ9BV94
Domains : Interpro (EBI)Glyco_hydro_47   
Domain families : Pfam (Sanger)Glyco_hydro_47 (PF01532)   
Domain families : Pfam (NCBI)pfam01532   
Conserved Domain (NCBI)EDEM2
DMDM Disease mutations55741
Blocks (Seattle)EDEM2
SuperfamilyQ9BV94
Human Protein AtlasENSG00000088298
Peptide AtlasQ9BV94
HPRD09841
IPIIPI00306178   IPI00432424   IPI01009926   IPI00908818   IPI01009224   
Protein Interaction databases
DIP (DOE-UCLA)Q9BV94
IntAct (EBI)Q9BV94
FunCoupENSG00000088298
BioGRIDEDEM2
STRING (EMBL)EDEM2
ZODIACEDEM2
Ontologies - Pathways
QuickGOQ9BV94
Ontology : AmiGOglycoprotein binding  alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  calcium ion binding  endoplasmic reticulum  endoplasmic reticulum lumen  N-glycan processing  membrane  ubiquitin-dependent ERAD pathway  endoplasmic reticulum unfolded protein response  trimming of terminal mannose on B branch  trimming of terminal mannose on B branch  trimming of terminal mannose on C branch  trimming of first mannose on A branch  trimming of second mannose on A branch  endoplasmic reticulum quality control compartment  ubiquitin-dependent glycoprotein ERAD pathway  positive regulation of retrograde protein transport, ER to cytosol  positive regulation of retrograde protein transport, ER to cytosol  mannose trimming involved in glycoprotein ERAD pathway  
Ontology : EGO-EBIglycoprotein binding  alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  calcium ion binding  endoplasmic reticulum  endoplasmic reticulum lumen  N-glycan processing  membrane  ubiquitin-dependent ERAD pathway  endoplasmic reticulum unfolded protein response  trimming of terminal mannose on B branch  trimming of terminal mannose on B branch  trimming of terminal mannose on C branch  trimming of first mannose on A branch  trimming of second mannose on A branch  endoplasmic reticulum quality control compartment  ubiquitin-dependent glycoprotein ERAD pathway  positive regulation of retrograde protein transport, ER to cytosol  positive regulation of retrograde protein transport, ER to cytosol  mannose trimming involved in glycoprotein ERAD pathway  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkEDEM2
Atlas of Cancer Signalling NetworkEDEM2
Wikipedia pathwaysEDEM2
Orthology - Evolution
OrthoDB55741
GeneTree (enSembl)ENSG00000088298
Phylogenetic Trees/Animal Genes : TreeFamEDEM2
HOVERGENQ9BV94
HOGENOMQ9BV94
Homologs : HomoloGeneEDEM2
Homology/Alignments : Family Browser (UCSC)EDEM2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEDEM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EDEM2
dbVarEDEM2
ClinVarEDEM2
1000_GenomesEDEM2 
Exome Variant ServerEDEM2
ExAC (Exome Aggregation Consortium)EDEM2 (select the gene name)
Genetic variants : HAPMAP55741
Genomic Variants (DGV)EDEM2 [DGVbeta]
DECIPHEREDEM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEDEM2 
Mutations
ICGC Data PortalEDEM2 
TCGA Data PortalEDEM2 
Broad Tumor PortalEDEM2
OASIS PortalEDEM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEDEM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEDEM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EDEM2
DgiDB (Drug Gene Interaction Database)EDEM2
DoCM (Curated mutations)EDEM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EDEM2 (select a term)
intoGenEDEM2
Cancer3DEDEM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610302   
Orphanet
MedgenEDEM2
Genetic Testing Registry EDEM2
NextProtQ9BV94 [Medical]
TSGene55741
GENETestsEDEM2
Target ValidationEDEM2
Huge Navigator EDEM2 [HugePedia]
snp3D : Map Gene to Disease55741
BioCentury BCIQEDEM2
ClinGenEDEM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55741
Chemical/Pharm GKB GenePA25747
Clinical trialEDEM2
Miscellaneous
canSAR (ICR)EDEM2 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEDEM2
EVEXEDEM2
GoPubMedEDEM2
iHOPEDEM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:06:50 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.