EDN2 (endothelin 2)

2007-02-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
ET-2,ET2,PPET2

Other Information

Locus ID:

NCBI: 1907
MIM: 131241
HGNC: 3177
Ensembl: ENSG00000127129

Variants:

dbSNP: 1907
ClinVar: 1907
TCGA: ENSG00000127129
COSMIC: EDN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127129ENST00000372587P20800

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
356796182022The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line.0
356796182022The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line.0
343609812021Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women.4
343609812021Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women.4
246473182015The comparison of traditional and modified harvesting techniques of left ınternal mammary artery regarding endothelin-1/2/3 expression and free flow capacity.0
246473182015The comparison of traditional and modified harvesting techniques of left ınternal mammary artery regarding endothelin-1/2/3 expression and free flow capacity.0
228656322013Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.24
235187062013Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.44
240438152013Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.30
228656322013Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.24
235187062013Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.44
240438152013Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.30
220476472012Expression of endothelin 2 and localized clear cell renal cell carcinoma.7
227277932012Altered endothelin expression in granulosa-lutein cells of women with polycystic ovary syndrome.2
229213042012Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease.5

Citation

Dessen P

EDN2 (endothelin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46014/edn2