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EDN2 (endothelin 2)

Identity

Alias_symbol (synonym)ET2
Other aliasET-2
PPET2
HGNC (Hugo) EDN2
LocusID (NCBI) 1907
Atlas_Id 46014
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 41944446 and ends at 41950354 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EDN2   3177
Cards
Entrez_Gene (NCBI)EDN2  1907  endothelin 2
AliasesET-2; ET2; PPET2
GeneCards (Weizmann)EDN2
Ensembl hg19 (Hinxton)ENSG00000127129 [Gene_View]  chr1:41944446-41950354 [Contig_View]  EDN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000127129 [Gene_View]  chr1:41944446-41950354 [Contig_View]  EDN2 [Vega]
ICGC DataPortalENSG00000127129
TCGA cBioPortalEDN2
AceView (NCBI)EDN2
Genatlas (Paris)EDN2
WikiGenes1907
SOURCE (Princeton)EDN2
Genetics Home Reference (NIH)EDN2
Genomic and cartography
GoldenPath hg19 (UCSC)EDN2  -     chr1:41944446-41950354 -  1p34.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EDN2  -     1p34.2   [Description]    (hg38-Dec_2013)
EnsemblEDN2 - 1p34.2 [CytoView hg19]  EDN2 - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIEDN2 [Mapview hg19]  EDN2 [Mapview hg38]
OMIM131241   
Gene and transcription
Genbank (Entrez)AW452560 BC034393 BI761655 HY177176 M65199
RefSeq transcript (Entrez)NM_001302269 NM_001956
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)EDN2
Cluster EST : UnigeneHs.1407 [ NCBI ]
CGAP (NCI)Hs.1407
Alternative Splicing GalleryENSG00000127129
Gene ExpressionEDN2 [ NCBI-GEO ]   EDN2 [ EBI - ARRAY_EXPRESS ]   EDN2 [ SEEK ]   EDN2 [ MEM ]
Gene Expression Viewer (FireBrowse)EDN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1907
GTEX Portal (Tissue expression)EDN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20800   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20800  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20800
Splice isoforms : SwissVarP20800
PhosPhoSitePlusP20800
Domaine pattern : Prosite (Expaxy)ENDOTHELIN (PS00270)   
Domains : Interpro (EBI)Bibrotoxin/Sarafotoxin-D    Endothelin_toxin_CS    Endothln-like_toxin    ET-2   
Domain families : Pfam (Sanger)Endothelin (PF00322)   
Domain families : Pfam (NCBI)pfam00322   
Domain families : Smart (EMBL)END (SM00272)  
Conserved Domain (NCBI)EDN2
DMDM Disease mutations1907
Blocks (Seattle)EDN2
SuperfamilyP20800
Human Protein AtlasENSG00000127129
Peptide AtlasP20800
HPRD07173
IPIIPI00025816   
Protein Interaction databases
DIP (DOE-UCLA)P20800
IntAct (EBI)P20800
FunCoupENSG00000127129
BioGRIDEDN2
STRING (EMBL)EDN2
ZODIACEDN2
Ontologies - Pathways
QuickGOP20800
Ontology : AmiGOprostaglandin biosynthetic process  temperature homeostasis  positive regulation of leukocyte chemotaxis  hormonal regulation of the force of heart contraction  positive regulation of the force of heart contraction by chemical signal  regulation of systemic arterial blood pressure by endothelin  hormone activity  extracellular region  extracellular space  intracellular  cell  cell surface receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  positive regulation of cell proliferation  positive regulation of heart rate  artery smooth muscle contraction  vein smooth muscle contraction  cytokine-mediated signaling pathway  regulation of vasoconstriction  calcium-mediated signaling  neutrophil chemotaxis  endothelin B receptor binding  macrophage activation  vasoconstriction  positive regulation of smooth muscle contraction  inositol phosphate-mediated signaling  macrophage chemotaxis  lung alveolus development  positive regulation of prostaglandin-endoperoxide synthase activity  energy homeostasis  
Ontology : EGO-EBIprostaglandin biosynthetic process  temperature homeostasis  positive regulation of leukocyte chemotaxis  hormonal regulation of the force of heart contraction  positive regulation of the force of heart contraction by chemical signal  regulation of systemic arterial blood pressure by endothelin  hormone activity  extracellular region  extracellular space  intracellular  cell  cell surface receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  positive regulation of cell proliferation  positive regulation of heart rate  artery smooth muscle contraction  vein smooth muscle contraction  cytokine-mediated signaling pathway  regulation of vasoconstriction  calcium-mediated signaling  neutrophil chemotaxis  endothelin B receptor binding  macrophage activation  vasoconstriction  positive regulation of smooth muscle contraction  inositol phosphate-mediated signaling  macrophage chemotaxis  lung alveolus development  positive regulation of prostaglandin-endoperoxide synthase activity  energy homeostasis  
NDEx NetworkEDN2
Atlas of Cancer Signalling NetworkEDN2
Wikipedia pathwaysEDN2
Orthology - Evolution
OrthoDB1907
GeneTree (enSembl)ENSG00000127129
Phylogenetic Trees/Animal Genes : TreeFamEDN2
HOVERGENP20800
HOGENOMP20800
Homologs : HomoloGeneEDN2
Homology/Alignments : Family Browser (UCSC)EDN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEDN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EDN2
dbVarEDN2
ClinVarEDN2
1000_GenomesEDN2 
Exome Variant ServerEDN2
ExAC (Exome Aggregation Consortium)EDN2 (select the gene name)
Genetic variants : HAPMAP1907
Genomic Variants (DGV)EDN2 [DGVbeta]
DECIPHER (Syndromes)1:41944446-41950354  ENSG00000127129
CONAN: Copy Number AnalysisEDN2 
Mutations
ICGC Data PortalEDN2 
TCGA Data PortalEDN2 
Broad Tumor PortalEDN2
OASIS PortalEDN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEDN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEDN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EDN2
DgiDB (Drug Gene Interaction Database)EDN2
DoCM (Curated mutations)EDN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EDN2 (select a term)
intoGenEDN2
Cancer3DEDN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131241   
Orphanet
MedgenEDN2
Genetic Testing Registry EDN2
NextProtP20800 [Medical]
TSGene1907
GENETestsEDN2
Huge Navigator EDN2 [HugePedia]
snp3D : Map Gene to Disease1907
BioCentury BCIQEDN2
ClinGenEDN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1907
Chemical/Pharm GKB GenePA27615
Clinical trialEDN2
Miscellaneous
canSAR (ICR)EDN2 (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEDN2
EVEXEDN2
GoPubMedEDN2
iHOPEDN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:59:41 CEST 2017

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