Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EDNRB (endothelin receptor type B)

Identity

Other namesABCDS
ET-B
ET-BR
ETB
ETBR
ETRB
HSCR
HSCR2
WS4A
HGNC (Hugo) EDNRB
LocusID (NCBI) 1910
Location 13q22.3
Location_base_pair Starts at 78469616 and ends at 78549664 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EDNRB   3180
Cards
Entrez_Gene (NCBI)EDNRB  1910  endothelin receptor type B
GeneCards (Weizmann)EDNRB
Ensembl (Hinxton)ENSG00000136160 [Gene_View]  chr13:78469616-78549664 [Contig_View]  EDNRB [Vega]
ICGC DataPortalENSG00000136160
cBioPortalEDNRB
AceView (NCBI)EDNRB
Genatlas (Paris)EDNRB
WikiGenes1910
SOURCE (Princeton)NM_000115 NM_001122659 NM_001201397 NM_003991
Genomic and cartography
GoldenPath (UCSC)EDNRB  -  13q22.3   chr13:78469616-78549664 -  13q22.3   [Description]    (hg19-Feb_2009)
EnsemblEDNRB - 13q22.3 [CytoView]
Mapping of homologs : NCBIEDNRB [Mapview]
OMIM131244   277580   600155   600501   
Gene and transcription
Genbank (Entrez)AB209198 AF114165 AK290699 AY275463 BC014472
RefSeq transcript (Entrez)NM_000115 NM_001122659 NM_001201397 NM_003991
RefSeq genomic (Entrez)AC_000145 NC_000013 NC_018924 NG_011630 NT_024524 NW_001838082 NW_004929388
Consensus coding sequences : CCDS (NCBI)EDNRB
Cluster EST : UnigeneHs.743195 [ NCBI ]
CGAP (NCI)Hs.743195
Alternative Splicing : Fast-db (Paris)GSHG0008557
Alternative Splicing GalleryENSG00000136160
Gene ExpressionEDNRB [ NCBI-GEO ]     EDNRB [ SEEK ]   EDNRB [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24530 (Uniprot)
NextProtP24530  [Medical]
With graphics : InterProP24530
Splice isoforms : SwissVarP24530 (Swissvar)
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Endthln_rcpt [organisation]   ETB_rcpt [organisation]   GPCR_Rhodpsn [organisation]   GPCR_Rhodpsn_7TM [organisation]  
Related proteins : CluSTrP24530
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
DMDM Disease mutations1910
Blocks (Seattle)P24530
Human Protein AtlasENSG00000136160 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP24530
HPRD08834
IPIIPI00029123   IPI00218197   IPI00412464   
Protein Interaction databases
DIP (DOE-UCLA)P24530
IntAct (EBI)P24530
FunCoupENSG00000136160
BioGRIDEDNRB
InParanoidP24530
Interologous Interaction database P24530
IntegromeDBEDNRB
STRING (EMBL)EDNRB
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  neural crest cell migration  positive regulation of protein phosphorylation  endothelin receptor activity  endothelin receptor activity  protein binding  plasma membrane  integral to plasma membrane  regulation of pH  cell surface receptor signaling pathway  negative regulation of adenylate cyclase activity  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  nervous system development  peripheral nervous system development  posterior midgut development  aging  regulation of blood pressure  positive regulation of cell proliferation  negative regulation of neuron maturation  response to organic cyclic compound  vein smooth muscle contraction  peptide hormone binding  sensory perception of pain  cGMP-mediated signaling  melanocyte differentiation  type 1 angiotensin receptor binding  nuclear membrane  negative regulation of cellular protein metabolic process  enteric smooth muscle cell differentiation  positive regulation of urine volume  positive regulation of renal sodium excretion  epithelial fluid transport  vasoconstriction  vasodilation  negative regulation of apoptotic process  membrane raft  macrophage chemotaxis  response to pain  enteric nervous system development  regulation of epithelial cell proliferation  regulation of sensory perception of pain  positive regulation of penile erection  cellular response to lipopolysaccharide  endothelin receptor signaling pathway  endothelin receptor signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  neural crest cell migration  positive regulation of protein phosphorylation  endothelin receptor activity  endothelin receptor activity  protein binding  plasma membrane  integral to plasma membrane  regulation of pH  cell surface receptor signaling pathway  negative regulation of adenylate cyclase activity  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  nervous system development  peripheral nervous system development  posterior midgut development  aging  regulation of blood pressure  positive regulation of cell proliferation  negative regulation of neuron maturation  response to organic cyclic compound  vein smooth muscle contraction  peptide hormone binding  sensory perception of pain  cGMP-mediated signaling  melanocyte differentiation  type 1 angiotensin receptor binding  nuclear membrane  negative regulation of cellular protein metabolic process  enteric smooth muscle cell differentiation  positive regulation of urine volume  positive regulation of renal sodium excretion  epithelial fluid transport  vasoconstriction  vasodilation  negative regulation of apoptotic process  membrane raft  macrophage chemotaxis  response to pain  enteric nervous system development  regulation of epithelial cell proliferation  regulation of sensory perception of pain  positive regulation of penile erection  cellular response to lipopolysaccharide  endothelin receptor signaling pathway  endothelin receptor signaling pathway  
Pathways : BIOCARTARole of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]   
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Melanogenesis   
Protein Interaction DatabaseEDNRB
Wikipedia pathwaysEDNRB
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EDNRB
snp3D : Map Gene to Disease1910
SNP (GeneSNP Utah)EDNRB
SNP : HGBaseEDNRB
Genetic variants : HAPMAPEDNRB
Exome VariantEDNRB
1000_GenomesEDNRB 
ICGC programENSG00000136160 
Somatic Mutations in Cancer : COSMICEDNRB 
CONAN: Copy Number AnalysisEDNRB 
Mutations and Diseases : HGMDEDNRB
Genomic VariantsEDNRB  EDNRB [DGVbeta]
dbVarEDNRB
ClinVarEDNRB
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM131244    277580    600155    600501   
MedgenEDNRB
GENETestsEDNRB
Disease Genetic AssociationEDNRB
Huge Navigator EDNRB [HugePedia]  EDNRB [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneEDNRB
Homology/Alignments : Family Browser (UCSC)EDNRB
Phylogenetic Trees/Animal Genes : TreeFamEDNRB
Chemical/Protein Interactions : CTD1910
Chemical/Pharm GKB GenePA27618
Clinical trialEDNRB
Cancer Resource (Charite)ENSG00000136160
Other databases
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
CoreMineEDNRB
iHOPEDNRB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 16:53:51 CEST 2014

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