EEA1 (early endosome antigen 1)

2007-04-01  

Identity

HGNC
LOCATION
12q22
LOCUSID
ALIAS
MST105,MSTP105,ZFYVE2
FUSION GENES

Other Information

Locus ID:

NCBI: 8411
MIM: 605070
HGNC: 3185
Ensembl: ENSG00000102189

Variants:

dbSNP: 8411
ClinVar: 8411
TCGA: ENSG00000102189
COSMIC: EEA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102189ENST00000322349Q15075
ENSG00000102189ENST00000418984F8WE79
ENSG00000102189ENST00000549790F8W119
ENSG00000102189ENST00000553019F8VUZ7

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129637352003Induction of p38 mitogen-activated protein kinase reduces early endosome autoantigen 1 (EEA1) recruitment to phagosomal membranes.43
205344882010Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1).34
215560362012The p97 ATPase associates with EEA1 to regulate the size of early endosomes.34
275569452016An endosomal tether undergoes an entropic collapse to bring vesicles together.34
150526572004Association of early endosomal autoantigen 1 with macropinocytosis in EGF-stimulated A431 cells.24
171461462006Effect of 3-methyladenine on the fusion process of macropinosomes in EGF-stimulated A431 cells.22
164487882006Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1.21
163319662005Investigation of the binding geometry of a peripheral membrane protein.14
259986832015Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes.12
246442862014Engagement of the small GTPase Rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome.11

Citation

Dessen P

EEA1 (early endosome antigen 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46636/eea1