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EEA1 (early endosome antigen 1)

Identity

Alias_namesearly endosome antigen 1
Alias_symbol (synonym)ZFYVE2
Other aliasMST105
MSTP105
HGNC (Hugo) EEA1
LocusID (NCBI) 8411
Atlas_Id 46636
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 92772509 and ends at 92929331 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APLP2 (11q24.3) / EEA1 (12q22)APP (21q21.3) / EEA1 (12q22)BSG (19p13.3) / EEA1 (12q22)
COL4A2 (13q34) / EEA1 (12q22)DBNL (7p13) / EEA1 (12q22)EEA1 (12q22) / CRADD (12q22)
EEA1 (12q22) / MPG (16p13.3)EEA1 (12q22) / MUM1 (19p13.3)EEA1 (12q22) / PAH (12q23.2)
EEA1 (12q22) / TMCC3 (12q22)EEA1 (12q22) / UBE2N (12q22)EEA1 (12q22) / WDR61 (15q25.1)
LHFPL3 (7q22.2) / EEA1 (12q22)PTGDS (9q34.3) / EEA1 (12q22)SLC34A2 (4p15.2) / EEA1 (12q22)
VIM (10p13) / EEA1 (12q22)APLP2 11q24.3 / EEA1 12q22APP 21q21.3 / EEA1 12q22
BSG 19p13.3 / EEA1 12q22COL4A2 13q34 / EEA1 12q22DBNL 7p13 / EEA1 12q22
EEA1 12q22 / CRADD 12q22EEA1 12q22 / MPG 16p13.3EEA1 12q22 / PAH 12q23.2
EEA1 12q22 / TMCC3 12q22EEA1 12q22 / UBE2N 12q22LHFPL3 7q22.2 / EEA1 12q22
PTGDS 9q34.3 / EEA1 12q22SLC34A2 4p15.2 / EEA1 12q22VIM 10p13 / EEA1 12q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EEA1   3185
Cards
Entrez_Gene (NCBI)EEA1  8411  early endosome antigen 1
AliasesMST105; MSTP105; ZFYVE2
GeneCards (Weizmann)EEA1
Ensembl hg19 (Hinxton)ENSG00000102189 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102189 [Gene_View]  chr12:92772509-92929331 [Contig_View]  EEA1 [Vega]
ICGC DataPortalENSG00000102189
TCGA cBioPortalEEA1
AceView (NCBI)EEA1
Genatlas (Paris)EEA1
WikiGenes8411
SOURCE (Princeton)EEA1
Genetics Home Reference (NIH)EEA1
Genomic and cartography
GoldenPath hg38 (UCSC)EEA1  -     chr12:92772509-92929331 -  12q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EEA1  -     12q22   [Description]    (hg19-Feb_2009)
EnsemblEEA1 - 12q22 [CytoView hg19]  EEA1 - 12q22 [CytoView hg38]
Mapping of homologs : NCBIEEA1 [Mapview hg19]  EEA1 [Mapview hg38]
OMIM605070   
Gene and transcription
Genbank (Entrez)AF173389 AK292008 AK307918 BC017837 BC041930
RefSeq transcript (Entrez)NM_003566
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EEA1
Cluster EST : UnigeneHs.567367 [ NCBI ]
CGAP (NCI)Hs.567367
Alternative Splicing GalleryENSG00000102189
Gene ExpressionEEA1 [ NCBI-GEO ]   EEA1 [ EBI - ARRAY_EXPRESS ]   EEA1 [ SEEK ]   EEA1 [ MEM ]
Gene Expression Viewer (FireBrowse)EEA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8411
GTEX Portal (Tissue expression)EEA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15075   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15075  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15075
Splice isoforms : SwissVarQ15075
PhosPhoSitePlusQ15075
Domaine pattern : Prosite (Expaxy)ZF_FYVE (PS50178)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)   
Domain families : Pfam (NCBI)pfam01363   
Domain families : Smart (EMBL)FYVE (SM00064)  
Conserved Domain (NCBI)EEA1
DMDM Disease mutations8411
Blocks (Seattle)EEA1
PDB (SRS)1HYI    1HYJ    1JOC    3MJH   
PDB (PDBSum)1HYI    1HYJ    1JOC    3MJH   
PDB (IMB)1HYI    1HYJ    1JOC    3MJH   
PDB (RSDB)1HYI    1HYJ    1JOC    3MJH   
Structural Biology KnowledgeBase1HYI    1HYJ    1JOC    3MJH   
SCOP (Structural Classification of Proteins)1HYI    1HYJ    1JOC    3MJH   
CATH (Classification of proteins structures)1HYI    1HYJ    1JOC    3MJH   
SuperfamilyQ15075
Human Protein AtlasENSG00000102189
Peptide AtlasQ15075
HPRD05460
IPIIPI00329536   IPI00385088   IPI01010478   IPI01022215   IPI01022383   IPI00941708   
Protein Interaction databases
DIP (DOE-UCLA)Q15075
IntAct (EBI)Q15075
FunCoupENSG00000102189
BioGRIDEEA1
STRING (EMBL)EEA1
ZODIACEEA1
Ontologies - Pathways
QuickGOQ15075
Ontology : AmiGOnucleic acid binding  protein binding  calmodulin binding  1-phosphatidylinositol binding  cytoplasm  early endosome  cytosol  serine-pyruvate aminotransferase complex  endocytosis  vesicle fusion  zinc ion binding  membrane  synaptic vesicle to endosome fusion  extrinsic component of plasma membrane  GTP-dependent protein binding  early endosome membrane  viral RNA genome replication  protein homodimerization activity  axonal spine  early endosome to late endosome transport  recycling endosome  extracellular exosome  presynapse  
Ontology : EGO-EBInucleic acid binding  protein binding  calmodulin binding  1-phosphatidylinositol binding  cytoplasm  early endosome  cytosol  serine-pyruvate aminotransferase complex  endocytosis  vesicle fusion  zinc ion binding  membrane  synaptic vesicle to endosome fusion  extrinsic component of plasma membrane  GTP-dependent protein binding  early endosome membrane  viral RNA genome replication  protein homodimerization activity  axonal spine  early endosome to late endosome transport  recycling endosome  extracellular exosome  presynapse  
Pathways : BIOCARTAPhosphoinositides and their downstream targets. [Genes]    The role of FYVE-finger proteins in vesicle transport [Genes]   
Pathways : KEGGEndocytosis    Phagosome    Tuberculosis   
NDEx NetworkEEA1
Atlas of Cancer Signalling NetworkEEA1
Wikipedia pathwaysEEA1
Orthology - Evolution
OrthoDB8411
GeneTree (enSembl)ENSG00000102189
Phylogenetic Trees/Animal Genes : TreeFamEEA1
HOVERGENQ15075
HOGENOMQ15075
Homologs : HomoloGeneEEA1
Homology/Alignments : Family Browser (UCSC)EEA1
Gene fusions - Rearrangements
Fusion : MitelmanAPLP2/EEA1 [11q24.3/12q22]  [t(11;12)(q24;q22)]  
Fusion : MitelmanAPP/EEA1 [21q21.3/12q22]  [t(12;21)(q22;q21)]  
Fusion : MitelmanBSG/EEA1 [19p13.3/12q22]  [t(12;19)(q22;p13)]  
Fusion : MitelmanEEA1/MPG [12q22/16p13.3]  [t(12;16)(q22;p13)]  
Fusion : MitelmanEEA1/PAH [12q22/12q23.2]  [t(12;12)(q22;q23)]  
Fusion : MitelmanLHFPL3/EEA1 [7q22.2/12q22]  [t(7;12)(q22;q22)]  
Fusion : MitelmanPTGDS/EEA1 [9q34.3/12q22]  [t(9;12)(q34;q22)]  
Fusion : MitelmanSLC34A2/EEA1 [4p15.2/12q22]  [t(4;12)(p15;q22)]  
Fusion: TCGAAPLP2 11q24.3 EEA1 12q22 THCA
Fusion: TCGAAPP 21q21.3 EEA1 12q22 LGG
Fusion: TCGABSG 19p13.3 EEA1 12q22 THCA
Fusion: TCGACOL4A2 13q34 EEA1 12q22 KIRC
Fusion: TCGADBNL 7p13 EEA1 12q22 HNSC
Fusion: TCGAEEA1 12q22 CRADD 12q22 BLCA
Fusion: TCGAEEA1 12q22 MPG 16p13.3 OV
Fusion: TCGAEEA1 12q22 PAH 12q23.2 BRCA
Fusion: TCGAEEA1 12q22 TMCC3 12q22 BRCA
Fusion: TCGAEEA1 12q22 UBE2N 12q22 LUAD
Fusion: TCGALHFPL3 7q22.2 EEA1 12q22 LGG
Fusion: TCGAPTGDS 9q34.3 EEA1 12q22 LGG
Fusion: TCGASLC34A2 4p15.2 EEA1 12q22 LUAD
Fusion: TCGAVIM 10p13 EEA1 12q22 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEEA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEA1
dbVarEEA1
ClinVarEEA1
1000_GenomesEEA1 
Exome Variant ServerEEA1
ExAC (Exome Aggregation Consortium)EEA1 (select the gene name)
Genetic variants : HAPMAP8411
Genomic Variants (DGV)EEA1 [DGVbeta]
DECIPHEREEA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEEA1 
Mutations
ICGC Data PortalEEA1 
TCGA Data PortalEEA1 
Broad Tumor PortalEEA1
OASIS PortalEEA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEEA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEEA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EEA1
DgiDB (Drug Gene Interaction Database)EEA1
DoCM (Curated mutations)EEA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEA1 (select a term)
intoGenEEA1
Cancer3DEEA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605070   
Orphanet
MedgenEEA1
Genetic Testing Registry EEA1
NextProtQ15075 [Medical]
TSGene8411
GENETestsEEA1
Huge Navigator EEA1 [HugePedia]
snp3D : Map Gene to Disease8411
BioCentury BCIQEEA1
ClinGenEEA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8411
Chemical/Pharm GKB GenePA27621
Clinical trialEEA1
Miscellaneous
canSAR (ICR)EEA1 (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEEA1
EVEXEEA1
GoPubMedEEA1
iHOPEEA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:14:14 CEST 2017

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