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EED (embryonic ectoderm development)

Identity

Alias (NCBI)COGIS
HEED
WAIT1
HGNC (Hugo) EED
HGNC Alias symbWAIT-1
HEED
HGNC Alias nameWD protein associating with integrin cytoplasmic tails 1
LocusID (NCBI) 8726
Atlas_Id 47375
Location 11q14.2  [Link to chromosome band 11q14]
Location_base_pair Starts at 86244753 and ends at 86278810 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CFL1 (11q13.1) / EED (11q14.2)EED (11q14.2) / AOAH (7p14.2)EED (11q14.2) / SRSF4 (1p35.3)
GATC (12q24.31) / EED (11q14.2)NSF (17q21.31) / EED (11q14.2)NSF 17q21.31 / EED 11q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Early T-cell precursor acute lymphoblastic leukemia
Pediatric T-Cell Acute Lymphoblastic Leukemia


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Weaver syndrome


External links

 

Nomenclature
HGNC (Hugo)EED   3188
Cards
Entrez_Gene (NCBI)EED    embryonic ectoderm development
AliasesCOGIS; HEED; WAIT1
GeneCards (Weizmann)EED
Ensembl hg19 (Hinxton)ENSG00000074266 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074266 [Gene_View]  ENSG00000074266 [Sequence]  chr11:86244753-86278810 [Contig_View]  EED [Vega]
ICGC DataPortalENSG00000074266
TCGA cBioPortalEED
AceView (NCBI)EED
Genatlas (Paris)EED
SOURCE (Princeton)EED
Genetics Home Reference (NIH)EED
Genomic and cartography
GoldenPath hg38 (UCSC)EED  -     chr11:86244753-86278810 +  11q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EED  -     11q14.2   [Description]    (hg19-Feb_2009)
GoldenPathEED - 11q14.2 [CytoView hg19]  EED - 11q14.2 [CytoView hg38]
ImmunoBaseENSG00000074266
Genome Data Viewer NCBIEED [Mapview hg19]  
OMIM605984   617561   
Gene and transcription
Genbank (Entrez)AA811323 AF070418 AF078933 AF080227 AF099032
RefSeq transcript (Entrez)NM_001308007 NM_001330334 NM_003797 NM_152991
Consensus coding sequences : CCDS (NCBI)EED
Gene ExpressionEED [ NCBI-GEO ]   EED [ EBI - ARRAY_EXPRESS ]   EED [ SEEK ]   EED [ MEM ]
Gene Expression Viewer (FireBrowse)EED [ Firebrowse - Broad ]
GenevisibleExpression of EED in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8726
GTEX Portal (Tissue expression)EED
Human Protein AtlasENSG00000074266-EED [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75530   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75530  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75530
PhosPhoSitePlusO75530
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Polycomb_EED    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)EED
PDB (RSDB)3IIW    3IIY    3IJ0    3IJ1    3IJC    3JPX    3JZG    3JZH    3JZN    3K26    3K27    4W2R    4X3E    5GSA    5H13    5H14    5H15    5H17    5H19    5H24    5H25    5HYN    5IJ7    5IJ8    5K0M    5LS6    5TTW    5U5H    5U5K    5U5T    5U62    5U69    5U6D    5U8A    5U8F    5WG6    5WP3    5WUK    6B3W    6C23    6C24    6SFB    6SFC    6U4Y    6W7F    6W7G   
PDB Europe3IIW    3IIY    3IJ0    3IJ1    3IJC    3JPX    3JZG    3JZH    3JZN    3K26    3K27    4W2R    4X3E    5GSA    5H13    5H14    5H15    5H17    5H19    5H24    5H25    5HYN    5IJ7    5IJ8    5K0M    5LS6    5TTW    5U5H    5U5K    5U5T    5U62    5U69    5U6D    5U8A    5U8F    5WG6    5WP3    5WUK    6B3W    6C23    6C24    6SFB    6SFC    6U4Y    6W7F    6W7G   
PDB (PDBSum)3IIW    3IIY    3IJ0    3IJ1    3IJC    3JPX    3JZG    3JZH    3JZN    3K26    3K27    4W2R    4X3E    5GSA    5H13    5H14    5H15    5H17    5H19    5H24    5H25    5HYN    5IJ7    5IJ8    5K0M    5LS6    5TTW    5U5H    5U5K    5U5T    5U62    5U69    5U6D    5U8A    5U8F    5WG6    5WP3    5WUK    6B3W    6C23    6C24    6SFB    6SFC    6U4Y    6W7F    6W7G   
PDB (IMB)3IIW    3IIY    3IJ0    3IJ1    3IJC    3JPX    3JZG    3JZH    3JZN    3K26    3K27    4W2R    4X3E    5GSA    5H13    5H14    5H15    5H17    5H19    5H24    5H25    5HYN    5IJ7    5IJ8    5K0M    5LS6    5TTW    5U5H    5U5K    5U5T    5U62    5U69    5U6D    5U8A    5U8F    5WG6    5WP3    5WUK    6B3W    6C23    6C24    6SFB    6SFC    6U4Y    6W7F    6W7G   
Structural Biology KnowledgeBase3IIW    3IIY    3IJ0    3IJ1    3IJC    3JPX    3JZG    3JZH    3JZN    3K26    3K27    4W2R    4X3E    5GSA    5H13    5H14    5H15    5H17    5H19    5H24    5H25    5HYN    5IJ7    5IJ8    5K0M    5LS6    5TTW    5U5H    5U5K    5U5T    5U62    5U69    5U6D    5U8A    5U8F    5WG6    5WP3    5WUK    6B3W    6C23    6C24    6SFB    6SFC    6U4Y    6W7F    6W7G   
SCOP (Structural Classification of Proteins)3IIW    3IIY    3IJ0    3IJ1    3IJC    3JPX    3JZG    3JZH    3JZN    3K26    3K27    4W2R    4X3E    5GSA    5H13    5H14    5H15    5H17    5H19    5H24    5H25    5HYN    5IJ7    5IJ8    5K0M    5LS6    5TTW    5U5H    5U5K    5U5T    5U62    5U69    5U6D    5U8A    5U8F    5WG6    5WP3    5WUK    6B3W    6C23    6C24    6SFB    6SFC    6U4Y    6W7F    6W7G   
CATH (Classification of proteins structures)3IIW    3IIY    3IJ0    3IJ1    3IJC    3JPX    3JZG    3JZH    3JZN    3K26    3K27    4W2R    4X3E    5GSA    5H13    5H14    5H15    5H17    5H19    5H24    5H25    5HYN    5IJ7    5IJ8    5K0M    5LS6    5TTW    5U5H    5U5K    5U5T    5U62    5U69    5U6D    5U8A    5U8F    5WG6    5WP3    5WUK    6B3W    6C23    6C24    6SFB    6SFC    6U4Y    6W7F    6W7G   
SuperfamilyO75530
AlphaFold pdb e-kbO75530   
Human Protein Atlas [tissue]ENSG00000074266-EED [tissue]
HPRD09343
Protein Interaction databases
DIP (DOE-UCLA)O75530
IntAct (EBI)O75530
BioGRIDEED
STRING (EMBL)EED
ZODIACEED
Ontologies - Pathways
QuickGOO75530
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  transcription corepressor binding  protein binding  nucleus  nucleoplasm  nucleoplasm  chromosome  cytosol  chromatin silencing  enzyme activator activity  viral life cycle  spinal cord development  nucleosome binding  ESC/E(Z) complex  ESC/E(Z) complex  histone methyltransferase activity  identical protein binding  negative regulation of gene expression, epigenetic  negative regulation of transcription, DNA-templated  histone methyltransferase activity (H3-K27 specific)  negative regulation of G0 to G1 transition  histone H3-K27 methylation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  transcription corepressor binding  protein binding  nucleus  nucleoplasm  nucleoplasm  chromosome  cytosol  chromatin silencing  enzyme activator activity  viral life cycle  spinal cord development  nucleosome binding  ESC/E(Z) complex  ESC/E(Z) complex  histone methyltransferase activity  identical protein binding  negative regulation of gene expression, epigenetic  negative regulation of transcription, DNA-templated  histone methyltransferase activity (H3-K27 specific)  negative regulation of G0 to G1 transition  histone H3-K27 methylation  
Pathways : BIOCARTAThe PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails [Genes]   
NDEx NetworkEED
Atlas of Cancer Signalling NetworkEED
Wikipedia pathwaysEED
Orthology - Evolution
OrthoDB8726
GeneTree (enSembl)ENSG00000074266
Phylogenetic Trees/Animal Genes : TreeFamEED
Homologs : HomoloGeneEED
Homology/Alignments : Family Browser (UCSC)EED
Gene fusions - Rearrangements
Fusion : MitelmanNSF/EED [17q21.31/11q14.2]  
Fusion : QuiverEED
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEED [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EED
dbVarEED
ClinVarEED
MonarchEED
1000_GenomesEED 
Exome Variant ServerEED
GNOMAD BrowserENSG00000074266
Varsome BrowserEED
ACMGEED variants
VarityO75530
Genomic Variants (DGV)EED [DGVbeta]
DECIPHEREED [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEED 
Mutations
ICGC Data PortalEED 
TCGA Data PortalEED 
Broad Tumor PortalEED
OASIS PortalEED [ Somatic mutations - Copy number]
Cancer Gene: CensusEED 
Somatic Mutations in Cancer : COSMICEED  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEED
Mutations and Diseases : HGMDEED
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEED
DgiDB (Drug Gene Interaction Database)EED
DoCM (Curated mutations)EED
CIViC (Clinical Interpretations of Variants in Cancer)EED
Cancer3DEED
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605984    617561   
Orphanet
DisGeNETEED
MedgenEED
Genetic Testing Registry EED
NextProtO75530 [Medical]
GENETestsEED
Target ValidationEED
Huge Navigator EED [HugePedia]
ClinGenEED
Clinical trials, drugs, therapy
MyCancerGenomeEED
Protein Interactions : CTDEED
Pharm GKB GenePA27624
PharosO75530
Clinical trialEED
Miscellaneous
canSAR (ICR)EED
HarmonizomeEED
DataMed IndexEED
Probes
Litterature
PubMed133 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEED
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:43 CEST 2021

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