Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EEF1B2 (eukaryotic translation elongation factor 1 beta 2)

Identity

Other aliasEEF1B
EEF1B1
EF1B
HGNC (Hugo) EEF1B2
LocusID (NCBI) 1933
Atlas_Id 43239
Location 2q33.3  [Link to chromosome band 2q33]
Location_base_pair Starts at 206159594 and ends at 206162929 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BLCAP (20q11.23) / EEF1B2 (2q33.3)CRIM1 (2p22.3) / EEF1B2 (2q33.3)EEF1B2 (2q33.3) / CDR1 (Xq27.1)
NDUFS1 (2q33.3) / EEF1B2 (2q33.3)CRIM1 2p22.3 / EEF1B2 2q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(p22;q33) CRIM1/EEF1B2

External links

Nomenclature
HGNC (Hugo)EEF1B2   3208
Cards
Entrez_Gene (NCBI)EEF1B2  1933  eukaryotic translation elongation factor 1 beta 2
AliasesEEF1B; EEF1B1; EF1B
GeneCards (Weizmann)EEF1B2
Ensembl hg19 (Hinxton)ENSG00000114942 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114942 [Gene_View]  chr2:206159594-206162929 [Contig_View]  EEF1B2 [Vega]
ICGC DataPortalENSG00000114942
TCGA cBioPortalEEF1B2
AceView (NCBI)EEF1B2
Genatlas (Paris)EEF1B2
WikiGenes1933
SOURCE (Princeton)EEF1B2
Genetics Home Reference (NIH)EEF1B2
Genomic and cartography
GoldenPath hg38 (UCSC)EEF1B2  -     chr2:206159594-206162929 +  2q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EEF1B2  -     2q33.3   [Description]    (hg19-Feb_2009)
EnsemblEEF1B2 - 2q33.3 [CytoView hg19]  EEF1B2 - 2q33.3 [CytoView hg38]
Mapping of homologs : NCBIEEF1B2 [Mapview hg19]  EEF1B2 [Mapview hg38]
OMIM600655   
Gene and transcription
Genbank (Entrez)AK291910 AK310096 BC000211 BC004931 BC029316
RefSeq transcript (Entrez)NM_001037663 NM_001959 NM_021121
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EEF1B2
Cluster EST : UnigeneHs.421608 [ NCBI ]
CGAP (NCI)Hs.421608
Alternative Splicing GalleryENSG00000114942
Gene ExpressionEEF1B2 [ NCBI-GEO ]   EEF1B2 [ EBI - ARRAY_EXPRESS ]   EEF1B2 [ SEEK ]   EEF1B2 [ MEM ]
Gene Expression Viewer (FireBrowse)EEF1B2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1933
GTEX Portal (Tissue expression)EEF1B2
Human Protein AtlasENSG00000114942-EEF1B2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24534   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24534  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24534
Splice isoforms : SwissVarP24534
PhosPhoSitePlusP24534
Domaine pattern : Prosite (Expaxy)EF1BD_1 (PS00824)    EF1BD_2 (PS00825)   
Domains : Interpro (EBI)EF-1_beta_acid_region_euk    EF1B_bsu/dsu_GNE    Glutathione-S-Trfase_C-like    Transl_elong_EF1B/ribosomal_S6    Transl_elong_EF1B_B/D_CS   
Domain families : Pfam (Sanger)EF-1_beta_acid (PF10587)    EF1_GNE (PF00736)   
Domain families : Pfam (NCBI)pfam10587    pfam00736   
Domain families : Smart (EMBL)EF-1_beta_acid (SM01182)  EF1_GNE (SM00888)  
Conserved Domain (NCBI)EEF1B2
DMDM Disease mutations1933
Blocks (Seattle)EEF1B2
PDB (SRS)1B64    5DQS   
PDB (PDBSum)1B64    5DQS   
PDB (IMB)1B64    5DQS   
PDB (RSDB)1B64    5DQS   
Structural Biology KnowledgeBase1B64    5DQS   
SCOP (Structural Classification of Proteins)1B64    5DQS   
CATH (Classification of proteins structures)1B64    5DQS   
SuperfamilyP24534
Human Protein Atlas [tissue]ENSG00000114942-EEF1B2 [tissue]
Peptide AtlasP24534
HPRD02804
IPIIPI00178440   IPI00927696   IPI00927920   IPI00926585   IPI00924908   
Protein Interaction databases
DIP (DOE-UCLA)P24534
IntAct (EBI)P24534
FunCoupENSG00000114942
BioGRIDEEF1B2
STRING (EMBL)EEF1B2
ZODIACEEF1B2
Ontologies - Pathways
QuickGOP24534
Ontology : AmiGOtranslation elongation factor activity  protein binding  nucleus  cytoplasm  endoplasmic reticulum  cytosol  eukaryotic translation elongation factor 1 complex  translational elongation  translational elongation  
Ontology : EGO-EBItranslation elongation factor activity  protein binding  nucleus  cytoplasm  endoplasmic reticulum  cytosol  eukaryotic translation elongation factor 1 complex  translational elongation  translational elongation  
NDEx NetworkEEF1B2
Atlas of Cancer Signalling NetworkEEF1B2
Wikipedia pathwaysEEF1B2
Orthology - Evolution
OrthoDB1933
GeneTree (enSembl)ENSG00000114942
Phylogenetic Trees/Animal Genes : TreeFamEEF1B2
HOVERGENP24534
HOGENOMP24534
Homologs : HomoloGeneEEF1B2
Homology/Alignments : Family Browser (UCSC)EEF1B2
Gene fusions - Rearrangements
Fusion : MitelmanCRIM1/EEF1B2 [2p22.3/2q33.3]  [t(2;2)(p22;q33)]  
Fusion: TCGA_MDACCCRIM1 2p22.3 EEF1B2 2q33.3 KIRC
Fusion PortalCRIM1 2p22.3 EEF1B2 2q33.3 KIRC
Fusion : QuiverEEF1B2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEEF1B2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEF1B2
dbVarEEF1B2
ClinVarEEF1B2
1000_GenomesEEF1B2 
Exome Variant ServerEEF1B2
ExAC (Exome Aggregation Consortium)ENSG00000114942
GNOMAD BrowserENSG00000114942
Genetic variants : HAPMAP1933
Genomic Variants (DGV)EEF1B2 [DGVbeta]
DECIPHEREEF1B2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEEF1B2 
Mutations
ICGC Data PortalEEF1B2 
TCGA Data PortalEEF1B2 
Broad Tumor PortalEEF1B2
OASIS PortalEEF1B2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEEF1B2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEEF1B2
intOGen PortalEEF1B2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EEF1B2
DgiDB (Drug Gene Interaction Database)EEF1B2
DoCM (Curated mutations)EEF1B2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEF1B2 (select a term)
intoGenEEF1B2
Cancer3DEEF1B2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600655   
Orphanet
DisGeNETEEF1B2
MedgenEEF1B2
Genetic Testing Registry EEF1B2
NextProtP24534 [Medical]
TSGene1933
GENETestsEEF1B2
Target ValidationEEF1B2
Huge Navigator EEF1B2 [HugePedia]
snp3D : Map Gene to Disease1933
BioCentury BCIQEEF1B2
ClinGenEEF1B2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1933
Chemical/Pharm GKB GenePA27644
Clinical trialEEF1B2
Miscellaneous
canSAR (ICR)EEF1B2 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEEF1B2
EVEXEEF1B2
GoPubMedEEF1B2
iHOPEEF1B2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:10:44 CET 2018
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