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EEF1D (eukaryotic translation elongation factor 1 delta)

Identity

Alias_nameseukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Alias_symbol (synonym)EF-1D
FLJ20897
Other aliasEF1D
FP1047
HGNC (Hugo) EEF1D
LocusID (NCBI) 1936
Atlas_Id 43240
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 143579722 and ends at 143597675 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
B2M (15q21.1) / EEF1D (8q24.3)EEF1D (8q24.3) / EEF1D (8q24.3)EEF1D (8q24.3) / NAPRT (8q24.3)
EEF1D (8q24.3) / NFKBIB (19q13.2)EEF1D (8q24.3) / TSTA3 (8q24.3)EEF1D (8q24.3) / UBE2L3 (22q11.21)
FAM104A (17q25.1) / EEF1D (8q24.3)HIF1A (14q23.2) / EEF1D (8q24.3)IGLL5 (22q11.22) / EEF1D (8q24.3)
OGG1 (3p25.3) / EEF1D (8q24.3)PMF1 (1q22) / EEF1D (8q24.3)PSMB7 (9q33.3) / EEF1D (8q24.3)
RPL30 (8q22.2) / EEF1D (8q24.3)SORT1 (1p13.3) / EEF1D (8q24.3)XRN2 (20p11.23) / EEF1D (8q24.3)
ZC3H3 (8q24.3) / EEF1D (8q24.3)EEF1D 8q24.3 / TSTA3 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  EEF1D/TSTA3 (8q24)

External links

Nomenclature
HGNC (Hugo)EEF1D   3211
Cards
Entrez_Gene (NCBI)EEF1D  1936  eukaryotic translation elongation factor 1 delta
AliasesEF-1D; EF1D; FP1047
GeneCards (Weizmann)EEF1D
Ensembl hg19 (Hinxton)ENSG00000104529 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104529 [Gene_View]  ENSG00000104529 [Sequence]  chr8:143579722-143597675 [Contig_View]  EEF1D [Vega]
ICGC DataPortalENSG00000104529
TCGA cBioPortalEEF1D
AceView (NCBI)EEF1D
Genatlas (Paris)EEF1D
WikiGenes1936
SOURCE (Princeton)EEF1D
Genetics Home Reference (NIH)EEF1D
Genomic and cartography
GoldenPath hg38 (UCSC)EEF1D  -     chr8:143579722-143597675 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EEF1D  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblEEF1D - 8q24.3 [CytoView hg19]  EEF1D - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIEEF1D [Mapview hg19]  EEF1D [Mapview hg38]
OMIM130592   
Gene and transcription
Genbank (Entrez)AF370363 AI366989 AK024550 AK093756 AK225040
RefSeq transcript (Entrez)NM_001130053 NM_001130054 NM_001130055 NM_001130056 NM_001130057 NM_001195203 NM_001289950 NM_001317743 NM_001330646 NM_001960 NM_032378
RefSeq genomic (Entrez)NC_000008 NT_187571
Consensus coding sequences : CCDS (NCBI)EEF1D
Cluster EST : UnigeneHs.703306 [ NCBI ]
CGAP (NCI)Hs.703306
Alternative Splicing GalleryENSG00000104529
Gene ExpressionEEF1D [ NCBI-GEO ]   EEF1D [ EBI - ARRAY_EXPRESS ]   EEF1D [ SEEK ]   EEF1D [ MEM ]
Gene Expression Viewer (FireBrowse)EEF1D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1936
GTEX Portal (Tissue expression)EEF1D
Human Protein AtlasENSG00000104529-EEF1D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29692   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29692  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29692
Splice isoforms : SwissVarP29692
PhosPhoSitePlusP29692
Domaine pattern : Prosite (Expaxy)EF1BD_1 (PS00824)    EF1BD_2 (PS00825)   
Domains : Interpro (EBI)eEF-1beta-like_sf    EF-1_beta_acid_region_euk    EF1B_bsu/dsu_GNE    Transl_elong_EF1B/ribosomal_S6    Transl_elong_EF1B_B/D_CS   
Domain families : Pfam (Sanger)EF-1_beta_acid (PF10587)    EF1_GNE (PF00736)   
Domain families : Pfam (NCBI)pfam10587    pfam00736   
Domain families : Smart (EMBL)EF-1_beta_acid (SM01182)  EF1_GNE (SM00888)  
Conserved Domain (NCBI)EEF1D
DMDM Disease mutations1936
Blocks (Seattle)EEF1D
PDB (RSDB)2MVM    2MVN    2N51    5JPO   
PDB Europe2MVM    2MVN    2N51    5JPO   
PDB (PDBSum)2MVM    2MVN    2N51    5JPO   
PDB (IMB)2MVM    2MVN    2N51    5JPO   
Structural Biology KnowledgeBase2MVM    2MVN    2N51    5JPO   
SCOP (Structural Classification of Proteins)2MVM    2MVN    2N51    5JPO   
CATH (Classification of proteins structures)2MVM    2MVN    2N51    5JPO   
SuperfamilyP29692
Human Protein Atlas [tissue]ENSG00000104529-EEF1D [tissue]
Peptide AtlasP29692
HPRD00560
IPIIPI00023048   IPI00642971   IPI01009986   IPI00432356   IPI00982982   IPI00868909   IPI00985353   IPI00064086   IPI01013278   IPI00980105   IPI00981244   IPI00979002   IPI01009351   IPI01015965   IPI00792430   IPI00980230   IPI00978462   IPI00795920   IPI00984413   IPI00980590   IPI00981909   IPI00976417   IPI00982699   IPI00979449   IPI00982433   IPI00984173   IPI00977237   IPI00977923   IPI00976644   IPI00985447   IPI00983770   IPI00983108   IPI00979070   IPI00984808   IPI00978855   IPI00980791   IPI00977067   IPI00981822   IPI00982062   IPI00975963   IPI00976589   IPI00977285   IPI00981462   IPI00979705   
Protein Interaction databases
DIP (DOE-UCLA)P29692
IntAct (EBI)P29692
FunCoupENSG00000104529
BioGRIDEEF1D
STRING (EMBL)EEF1D
ZODIACEEF1D
Ontologies - Pathways
QuickGOP29692
Ontology : AmiGOfibrillar center  DNA binding  translation elongation factor activity  protein binding  nucleus  nucleus  cytoplasm  endoplasmic reticulum  cytosol  cytosol  eukaryotic translation elongation factor 1 complex  translational elongation  translation factor activity, RNA binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  cadherin binding  cellular response to ionizing radiation  
Ontology : EGO-EBIfibrillar center  DNA binding  translation elongation factor activity  protein binding  nucleus  nucleus  cytoplasm  endoplasmic reticulum  cytosol  cytosol  eukaryotic translation elongation factor 1 complex  translational elongation  translation factor activity, RNA binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  cadherin binding  cellular response to ionizing radiation  
Pathways : KEGGHerpes simplex infection   
NDEx NetworkEEF1D
Atlas of Cancer Signalling NetworkEEF1D
Wikipedia pathwaysEEF1D
Orthology - Evolution
OrthoDB1936
GeneTree (enSembl)ENSG00000104529
Phylogenetic Trees/Animal Genes : TreeFamEEF1D
HOGENOMP29692
Homologs : HomoloGeneEEF1D
Homology/Alignments : Family Browser (UCSC)EEF1D
Gene fusions - Rearrangements
Fusion : MitelmanEEF1D/TSTA3 [8q24.3/8q24.3]  
Fusion PortalEEF1D 8q24.3 TSTA3 8q24.3 LUAD
Fusion : QuiverEEF1D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEEF1D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEF1D
dbVarEEF1D
ClinVarEEF1D
1000_GenomesEEF1D 
Exome Variant ServerEEF1D
ExAC (Exome Aggregation Consortium)ENSG00000104529
GNOMAD BrowserENSG00000104529
Varsome BrowserEEF1D
Genetic variants : HAPMAP1936
Genomic Variants (DGV)EEF1D [DGVbeta]
DECIPHEREEF1D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEEF1D 
Mutations
ICGC Data PortalEEF1D 
TCGA Data PortalEEF1D 
Broad Tumor PortalEEF1D
OASIS PortalEEF1D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEEF1D  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEEF1D
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EEF1D
DgiDB (Drug Gene Interaction Database)EEF1D
DoCM (Curated mutations)EEF1D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEF1D (select a term)
intoGenEEF1D
Cancer3DEEF1D(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM130592   
Orphanet
DisGeNETEEF1D
MedgenEEF1D
Genetic Testing Registry EEF1D
NextProtP29692 [Medical]
TSGene1936
GENETestsEEF1D
Target ValidationEEF1D
Huge Navigator EEF1D [HugePedia]
snp3D : Map Gene to Disease1936
BioCentury BCIQEEF1D
ClinGenEEF1D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1936
Chemical/Pharm GKB GenePA27647
Clinical trialEEF1D
Miscellaneous
canSAR (ICR)EEF1D (select the gene name)
DataMed IndexEEF1D
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEEF1D
EVEXEEF1D
GoPubMedEEF1D
iHOPEEF1D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:10:46 CET 2019
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