Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EEF1G (eukaryotic translation elongation factor 1 gamma)

Identity

Alias_symbol (synonym)EF1G
Other aliasGIG35
HGNC (Hugo) EEF1G
LocusID (NCBI) 1937
Atlas_Id 54272
Location 11q12.3  [Link to chromosome band 11q12]
Location_base_pair Starts at 62559601 and ends at 62573988 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EEF1G (11q12.3) / EEF1G (11q12.3)EEF1G (11q12.3) / MTA2 (11q12.3)EEF1G (11q12.3) / MYH9 (22q12.3)
EEF1G (11q12.3) / OOEP (6q13)EEF1G (11q12.3) / PPP6R3 (11q13.2)EEF1G (11q12.3) / TOX2 (20q13.12)
EEF1G (11q12.3) / UBXN1 (11q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;11)(q13;q12) EEF1G/OOEP

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(11;11)(q12;q13) EEF1G/PPP6R3

External links

Nomenclature
HGNC (Hugo)EEF1G   3213
Cards
Entrez_Gene (NCBI)EEF1G  1937  eukaryotic translation elongation factor 1 gamma
AliasesEF1G; GIG35
GeneCards (Weizmann)EEF1G
Ensembl hg19 (Hinxton)ENSG00000254772 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000254772 [Gene_View]  ENSG00000254772 [Sequence]  chr11:62559601-62573988 [Contig_View]  EEF1G [Vega]
ICGC DataPortalENSG00000254772
TCGA cBioPortalEEF1G
AceView (NCBI)EEF1G
Genatlas (Paris)EEF1G
WikiGenes1937
SOURCE (Princeton)EEF1G
Genetics Home Reference (NIH)EEF1G
Genomic and cartography
GoldenPath hg38 (UCSC)EEF1G  -     chr11:62559601-62573988 -  11q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EEF1G  -     11q12.3   [Description]    (hg19-Feb_2009)
EnsemblEEF1G - 11q12.3 [CytoView hg19]  EEF1G - 11q12.3 [CytoView hg38]
Mapping of homologs : NCBIEEF1G [Mapview hg19]  EEF1G [Mapview hg38]
OMIM130593   
Gene and transcription
Genbank (Entrez)AK092787 AK129569 AK129618 AK130026 AK299876
RefSeq transcript (Entrez)NM_001404
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EEF1G
Cluster EST : UnigeneHs.444467 [ NCBI ]
CGAP (NCI)Hs.444467
Alternative Splicing GalleryENSG00000254772
Gene ExpressionEEF1G [ NCBI-GEO ]   EEF1G [ EBI - ARRAY_EXPRESS ]   EEF1G [ SEEK ]   EEF1G [ MEM ]
Gene Expression Viewer (FireBrowse)EEF1G [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1937
GTEX Portal (Tissue expression)EEF1G
Human Protein AtlasENSG00000254772-EEF1G [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26641   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26641  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26641
Splice isoforms : SwissVarP26641
PhosPhoSitePlusP26641
Domaine pattern : Prosite (Expaxy)EF1G_C (PS50040)    GST_CTER (PS50405)    GST_NTER (PS50404)   
Domains : Interpro (EBI)EF1B_G_C    EF1B_G_C_sf    Glutathione-S-Trfase_C-like    Glutathione-S-Trfase_C_sf    Glutathione_S-Trfase_N    GST_C    Thioredoxin-like_sf   
Domain families : Pfam (Sanger)EF1G (PF00647)    GST_C (PF00043)    GST_N (PF02798)   
Domain families : Pfam (NCBI)pfam00647    pfam00043    pfam02798   
Domain families : Smart (EMBL)EF1G (SM01183)  
Conserved Domain (NCBI)EEF1G
DMDM Disease mutations1937
Blocks (Seattle)EEF1G
PDB (RSDB)1PBU    5DQS    5JPO   
PDB Europe1PBU    5DQS    5JPO   
PDB (PDBSum)1PBU    5DQS    5JPO   
PDB (IMB)1PBU    5DQS    5JPO   
Structural Biology KnowledgeBase1PBU    5DQS    5JPO   
SCOP (Structural Classification of Proteins)1PBU    5DQS    5JPO   
CATH (Classification of proteins structures)1PBU    5DQS    5JPO   
SuperfamilyP26641
Human Protein Atlas [tissue]ENSG00000254772-EEF1G [tissue]
Peptide AtlasP26641
HPRD11745
IPIIPI00937615   IPI00000875   IPI00908389   IPI00909534   IPI01022639   
Protein Interaction databases
DIP (DOE-UCLA)P26641
IntAct (EBI)P26641
FunCoupENSG00000254772
BioGRIDEEF1G
STRING (EMBL)EEF1G
ZODIACEEF1G
Ontologies - Pathways
QuickGOP26641
Ontology : AmiGOtranslation elongation factor activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  translational elongation  translational elongation  response to virus  membrane  cadherin binding  extracellular exosome  
Ontology : EGO-EBItranslation elongation factor activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  translational elongation  translational elongation  response to virus  membrane  cadherin binding  extracellular exosome  
Pathways : KEGGLegionellosis   
NDEx NetworkEEF1G
Atlas of Cancer Signalling NetworkEEF1G
Wikipedia pathwaysEEF1G
Orthology - Evolution
OrthoDB1937
GeneTree (enSembl)ENSG00000254772
Phylogenetic Trees/Animal Genes : TreeFamEEF1G
HOGENOMP26641
Homologs : HomoloGeneEEF1G
Homology/Alignments : Family Browser (UCSC)EEF1G
Gene fusions - Rearrangements
Fusion : MitelmanEEF1G/OOEP [11q12.3/6q13]  
Fusion : MitelmanEEF1G/PPP6R3 [11q12.3/11q13.2]  [t(11;11)(q12;q13)]  
Fusion : QuiverEEF1G
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEEF1G [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEF1G
dbVarEEF1G
ClinVarEEF1G
1000_GenomesEEF1G 
Exome Variant ServerEEF1G
ExAC (Exome Aggregation Consortium)ENSG00000254772
GNOMAD BrowserENSG00000254772
Varsome BrowserEEF1G
Genetic variants : HAPMAP1937
Genomic Variants (DGV)EEF1G [DGVbeta]
DECIPHEREEF1G [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEEF1G 
Mutations
ICGC Data PortalEEF1G 
TCGA Data PortalEEF1G 
Broad Tumor PortalEEF1G
OASIS PortalEEF1G [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEEF1G  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEEF1G
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EEF1G
DgiDB (Drug Gene Interaction Database)EEF1G
DoCM (Curated mutations)EEF1G (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEF1G (select a term)
intoGenEEF1G
Cancer3DEEF1G(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM130593   
Orphanet
DisGeNETEEF1G
MedgenEEF1G
Genetic Testing Registry EEF1G
NextProtP26641 [Medical]
TSGene1937
GENETestsEEF1G
Target ValidationEEF1G
Huge Navigator EEF1G [HugePedia]
snp3D : Map Gene to Disease1937
BioCentury BCIQEEF1G
ClinGenEEF1G
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1937
Chemical/Pharm GKB GenePA27649
Clinical trialEEF1G
Miscellaneous
canSAR (ICR)EEF1G (select the gene name)
DataMed IndexEEF1G
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEEF1G
EVEXEEF1G
GoPubMedEEF1G
iHOPEEF1G
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Feb 14 16:28:27 CET 2019
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