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EEF2 (eukaryotic translation elongation factor 2)

Identity

Alias_namesEF2
Alias_symbol (synonym)EEF-2
Other aliasEF-2
SCA26
HGNC (Hugo) EEF2
LocusID (NCBI) 1938
Atlas_Id 40410
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3976056 and ends at 3985463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AP2S1 (19q13.32) / EEF2 (19p13.3)AUP1 (2p13.1) / EEF2 (19p13.3)C16orf52 (16p12.2) / EEF2 (19p13.3)
CES2 (16q22.1) / EEF2 (19p13.3)EEF2 (19p13.3) / ABHD6 (3p14.3)EEF2 (19p13.3) / CSNK1D (17q25.3)
EEF2 (19p13.3) / DLC1 (8p22)EEF2 (19p13.3) / EEF2 (19p13.3)EEF2 (19p13.3) / F10 (13q34)
EEF2 (19p13.3) / GAPDHP72 ()EEF2 (19p13.3) / LRRC4B (19q13.33)EEF2 (19p13.3) / MAP2K2 (19p13.3)
EEF2 (19p13.3) / NSD1 (5q35.2)EEF2 (19p13.3) / OSR2 (8q22.2)EEF2 (19p13.3) / PEX14 (1p36.22)
EEF2 (19p13.3) / PPIB (15q22.31)EEF2 (19p13.3) / RAB1B (11q13.2)EEF2 (19p13.3) / SLC25A10 (17q25.3)
EEF2 (19p13.3) / SLC25A42 (19p13.11)EEF2 (19p13.3) / SPTBN1 (2p16.2)EEF2 (19p13.3) / TAPBP (6p21.32)
HSD11B2 (16q22.1) / EEF2 (19p13.3)RPL18A (19p13.11) / EEF2 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EEF2   3214
Cards
Entrez_Gene (NCBI)EEF2  1938  eukaryotic translation elongation factor 2
AliasesEEF-2; EF-2; EF2; SCA26
GeneCards (Weizmann)EEF2
Ensembl hg19 (Hinxton)ENSG00000167658 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167658 [Gene_View]  chr19:3976056-3985463 [Contig_View]  EEF2 [Vega]
ICGC DataPortalENSG00000167658
TCGA cBioPortalEEF2
AceView (NCBI)EEF2
Genatlas (Paris)EEF2
WikiGenes1938
SOURCE (Princeton)EEF2
Genetics Home Reference (NIH)EEF2
Genomic and cartography
GoldenPath hg38 (UCSC)EEF2  -     chr19:3976056-3985463 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EEF2  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblEEF2 - 19p13.3 [CytoView hg19]  EEF2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIEEF2 [Mapview hg19]  EEF2 [Mapview hg38]
OMIM130610   609306   
Gene and transcription
Genbank (Entrez)AK297398 AK298498 AK299225 AU118535 AY942181
RefSeq transcript (Entrez)NM_001961
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EEF2
Cluster EST : UnigeneHs.515070 [ NCBI ]
CGAP (NCI)Hs.515070
Alternative Splicing GalleryENSG00000167658
Gene ExpressionEEF2 [ NCBI-GEO ]   EEF2 [ EBI - ARRAY_EXPRESS ]   EEF2 [ SEEK ]   EEF2 [ MEM ]
Gene Expression Viewer (FireBrowse)EEF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1938
GTEX Portal (Tissue expression)EEF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13639
Splice isoforms : SwissVarP13639
PhosPhoSitePlusP13639
Domaine pattern : Prosite (Expaxy)G_TR_1 (PS00301)    G_TR_2 (PS51722)   
Domains : Interpro (EBI)EFG_III-V    EFG_V    EFTu-like_2    G_TR_CS    P-loop_NTPase    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr    Small_GTP-bd_dom    TF_GTP-bd_dom    Transl_B-barrel    Transl_elong_EFG/EF2_IV   
Domain families : Pfam (Sanger)EFG_C (PF00679)    EFG_II (PF14492)    EFG_IV (PF03764)    GTP_EFTU_D2 (PF03144)   
Domain families : Pfam (NCBI)pfam00679    pfam14492    pfam03764    pfam03144   
Domain families : Smart (EMBL)EFG_C (SM00838)  EFG_IV (SM00889)  
Conserved Domain (NCBI)EEF2
DMDM Disease mutations1938
Blocks (Seattle)EEF2
PDB (SRS)4V6X   
PDB (PDBSum)4V6X   
PDB (IMB)4V6X   
PDB (RSDB)4V6X   
Structural Biology KnowledgeBase4V6X   
SCOP (Structural Classification of Proteins)4V6X   
CATH (Classification of proteins structures)4V6X   
SuperfamilyP13639
Human Protein AtlasENSG00000167658
Peptide AtlasP13639
HPRD00561
IPIIPI00186290   IPI00909570   IPI01010856   
Protein Interaction databases
DIP (DOE-UCLA)P13639
IntAct (EBI)P13639
FunCoupENSG00000167658
BioGRIDEEF2
STRING (EMBL)EEF2
ZODIACEEF2
Ontologies - Pathways
QuickGOP13639
Ontology : AmiGOp53 binding  hematopoietic progenitor cell differentiation  response to ischemia  skeletal muscle contraction  RNA binding  translation elongation factor activity  GTPase activity  protein binding  GTP binding  extracellular region  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  translational elongation  protein methylation  aging  5S rRNA binding  glial cell proliferation  membrane  aggresome  peptidyl-diphthamide biosynthetic process from peptidyl-histidine  protein kinase binding  intracellular ribonucleoprotein complex  extracellular matrix  response to estradiol  secretory granule lumen  response to endoplasmic reticulum stress  skeletal muscle cell differentiation  response to drug  response to hydrogen peroxide  polysomal ribosome  ribosome binding  neutrophil degranulation  membrane raft  cadherin binding  response to ethanol  positive regulation of translation  actin filament binding  response to folic acid  extracellular exosome  ficolin-1-rich granule lumen  cellular response to brain-derived neurotrophic factor stimulus  positive regulation of cytoplasmic translation  
Ontology : EGO-EBIp53 binding  hematopoietic progenitor cell differentiation  response to ischemia  skeletal muscle contraction  RNA binding  translation elongation factor activity  GTPase activity  protein binding  GTP binding  extracellular region  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  translational elongation  protein methylation  aging  5S rRNA binding  glial cell proliferation  membrane  aggresome  peptidyl-diphthamide biosynthetic process from peptidyl-histidine  protein kinase binding  intracellular ribonucleoprotein complex  extracellular matrix  response to estradiol  secretory granule lumen  response to endoplasmic reticulum stress  skeletal muscle cell differentiation  response to drug  response to hydrogen peroxide  polysomal ribosome  ribosome binding  neutrophil degranulation  membrane raft  cadherin binding  response to ethanol  positive regulation of translation  actin filament binding  response to folic acid  extracellular exosome  ficolin-1-rich granule lumen  cellular response to brain-derived neurotrophic factor stimulus  positive regulation of cytoplasmic translation  
Pathways : BIOCARTAEukaryotic protein translation [Genes]   
NDEx NetworkEEF2
Atlas of Cancer Signalling NetworkEEF2
Wikipedia pathwaysEEF2
Orthology - Evolution
OrthoDB1938
GeneTree (enSembl)ENSG00000167658
Phylogenetic Trees/Animal Genes : TreeFamEEF2
HOVERGENP13639
HOGENOMP13639
Homologs : HomoloGeneEEF2
Homology/Alignments : Family Browser (UCSC)EEF2
Gene fusions - Rearrangements
Fusion Cancer (Beijing)C16orf52 [16p12.2]  -  EEF2 [19p13.3]  [FUSC000301]
Fusion Cancer (Beijing)CES2 [16q22.1]  -  EEF2 [19p13.3]  [FUSC000267]
Fusion Cancer (Beijing)EEF2 [19p13.3]  -  DLC1 [8p22]  [FUSC000941]
Fusion Cancer (Beijing)EEF2 [19p13.3]  -  GAPDHP72 [-]  [FUSC000307]
Fusion Cancer (Beijing)EEF2 [19p13.3]  -  NSD1 [5q35.2]  [FUSC002228]
Fusion Cancer (Beijing)EEF2 [19p13.3]  -  SLC25A42 [19p13.11]  [FUSC004286]
Fusion Cancer (Beijing)HSD11B2 [16q22.1]  -  EEF2 [19p13.3]  [FUSC002160]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEEF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEF2
dbVarEEF2
ClinVarEEF2
1000_GenomesEEF2 
Exome Variant ServerEEF2
ExAC (Exome Aggregation Consortium)EEF2 (select the gene name)
Genetic variants : HAPMAP1938
Genomic Variants (DGV)EEF2 [DGVbeta]
DECIPHEREEF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEEF2 
Mutations
ICGC Data PortalEEF2 
TCGA Data PortalEEF2 
Broad Tumor PortalEEF2
OASIS PortalEEF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEEF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEEF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EEF2
DgiDB (Drug Gene Interaction Database)EEF2
DoCM (Curated mutations)EEF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEF2 (select a term)
intoGenEEF2
Cancer3DEEF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM130610    609306   
Orphanet14823   
MedgenEEF2
Genetic Testing Registry EEF2
NextProtP13639 [Medical]
TSGene1938
GENETestsEEF2
Target ValidationEEF2
Huge Navigator EEF2 [HugePedia]
snp3D : Map Gene to Disease1938
BioCentury BCIQEEF2
ClinGenEEF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1938
Chemical/Pharm GKB GenePA27650
Clinical trialEEF2
Miscellaneous
canSAR (ICR)EEF2 (select the gene name)
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEEF2
EVEXEEF2
GoPubMedEEF2
iHOPEEF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:52:18 CEST 2017

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