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EEF2K (eukaryotic elongation factor 2 kinase)

Identity

Other namesHSU93850
eEF-2K
HGNC (Hugo) EEF2K
LocusID (NCBI) 29904
Atlas_Id 40411
Location 16p12.2
Location_base_pair Starts at 22217592 and ends at 22300066 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
EEF2K 16p12.2 / C10orf35 10q22.1EEF2K 16p12.2 / UQCRC2 16p12.2EEF2K 16p12.2 / VWA3A 16p12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EEF2K   24615
Cards
Entrez_Gene (NCBI)EEF2K  29904  eukaryotic elongation factor 2 kinase
GeneCards (Weizmann)EEF2K
Ensembl hg19 (Hinxton)ENSG00000103319 [Gene_View]  chr16:22217592-22300066 [Contig_View]  EEF2K [Vega]
Ensembl hg38 (Hinxton)ENSG00000103319 [Gene_View]  chr16:22217592-22300066 [Contig_View]  EEF2K [Vega]
ICGC DataPortalENSG00000103319
TCGA cBioPortalEEF2K
AceView (NCBI)EEF2K
Genatlas (Paris)EEF2K
WikiGenes29904
SOURCE (Princeton)EEF2K
Genomic and cartography
GoldenPath hg19 (UCSC)EEF2K  -     chr16:22217592-22300066 +  16p12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EEF2K  -     16p12.2   [Description]    (hg38-Dec_2013)
EnsemblEEF2K - 16p12.2 [CytoView hg19]  EEF2K - 16p12.2 [CytoView hg38]
Mapping of homologs : NCBIEEF2K [Mapview hg19]  EEF2K [Mapview hg38]
OMIM606968   
Gene and transcription
Genbank (Entrez)AK022569 AK308757 AW675420 BC032665 CA397138
RefSeq transcript (Entrez)NM_013302
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_187260 NW_004929400
Consensus coding sequences : CCDS (NCBI)EEF2K
Cluster EST : UnigeneHs.498892 [ NCBI ]
CGAP (NCI)Hs.498892
Alternative Splicing : Fast-db (Paris)GSHG0011024
Alternative Splicing GalleryENSG00000103319
Gene ExpressionEEF2K [ NCBI-GEO ]     EEF2K [ SEEK ]   EEF2K [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)29904
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00418 (Uniprot)
NextProtO00418  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00418
Splice isoforms : SwissVarO00418 (Swissvar)
Catalytic activity : Enzyme2.7.11.20 [ Enzyme-Expasy ]   2.7.11.20 [ Enzyme-SRS ]   2.7.11.20 [ IntEnz-EBI ]   2.7.11.20 [ PRIAM ]   2.7.11.20 [ BRENDA ]   2.7.11.20 [ KEGG ]   2.7.11.20 [ IUBMB ]
PhosPhoSitePlusO00418
Domaine pattern : Prosite (Expaxy)ALPHA_KINASE (PS51158)   
Domains : Interpro (EBI)eEF-2K    Kinase-like_dom    MHCK_EF2_kinase    Sel1-like    TPR-like_helical_dom   
Domain families : Pfam (Sanger)Alpha_kinase (PF02816)    Sel1 (PF08238)   
Domain families : Pfam (NCBI)pfam02816    pfam08238   
Domain families : Smart (EMBL)Alpha_kinase (SM00811)  
DMDM Disease mutations29904
Blocks (Seattle)EEF2K
Human Protein AtlasENSG00000103319
Peptide AtlasO00418
HPRD07369
IPIIPI00011689   
Protein Interaction databases
DIP (DOE-UCLA)O00418
IntAct (EBI)O00418
FunCoupENSG00000103319
BioGRIDEEF2K
IntegromeDBEEF2K
STRING (EMBL)EEF2K
ZODIACEEF2K
Ontologies - Pathways
QuickGOO00418
Ontology : AmiGOprotein kinase activity  elongation factor-2 kinase activity  calcium ion binding  calmodulin binding  ATP binding  cytoplasm  cytosol  translational elongation  translation factor activity, RNA binding  insulin receptor signaling pathway  regulation of protein autophosphorylation  protein autophosphorylation  
Ontology : EGO-EBIprotein kinase activity  elongation factor-2 kinase activity  calcium ion binding  calmodulin binding  ATP binding  cytoplasm  cytosol  translational elongation  translation factor activity, RNA binding  insulin receptor signaling pathway  regulation of protein autophosphorylation  protein autophosphorylation  
Pathways : BIOCARTAEukaryotic protein translation [Genes]   
Protein Interaction DatabaseEEF2K
Atlas of Cancer Signalling NetworkEEF2K
Wikipedia pathwaysEEF2K
Orthology - Evolution
OrthoDB29904
GeneTree (enSembl)ENSG00000103319
Phylogenetic Trees/Animal Genes : TreeFamEEF2K
Homologs : HomoloGeneEEF2K
Homology/Alignments : Family Browser (UCSC)EEF2K
Gene fusions - Rearrangements
Fusion: TCGAEEF2K 16p12.2 C10orf35 10q22.1 LUSC
Fusion: TCGAEEF2K 16p12.2 UQCRC2 16p12.2 BRCA
Fusion: TCGAEEF2K 16p12.2 VWA3A 16p12.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerEEF2K [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEF2K
dbVarEEF2K
ClinVarEEF2K
1000_GenomesEEF2K 
Exome Variant ServerEEF2K
Exome Aggregation Consortium (ExAC)ENSG00000103319
SNP (GeneSNP Utah)EEF2K
SNP : HGBaseEEF2K
Genetic variants : HAPMAPEEF2K
Genomic Variants (DGV)EEF2K [DGVbeta]
Mutations
ICGC Data PortalEEF2K 
TCGA Data PortalEEF2K 
Tumor PortalEEF2K
TCGA Copy Number PortalEEF2K
Somatic Mutations in Cancer : COSMICEEF2K 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EEF2K
DgiDB (Drug Gene Interaction Database)EEF2K
DoCM (Curated mutations)EEF2K (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEF2K (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:22217592-22300066
CONAN: Copy Number AnalysisEEF2K 
Mutations and Diseases : HGMDEEF2K
OMIM606968   
MedgenEEF2K
NextProtO00418 [Medical]
TSGene29904
GENETestsEEF2K
Huge Navigator EEF2K [HugePedia]  EEF2K [HugeCancerGEM]
snp3D : Map Gene to Disease29904
BioCentury BCIQEEF2K
General knowledge
Chemical/Protein Interactions : CTD29904
Chemical/Pharm GKB GenePA134992891
Clinical trialEEF2K
Other databases
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEEF2K
GoPubMedEEF2K
iHOPEEF2K
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 18:32:06 CET 2016

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