Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EEF2K (eukaryotic elongation factor 2 kinase)

Identity

Alias_symbol (synonym)eEF-2K
Other aliasHSU93850
HGNC (Hugo) EEF2K
LocusID (NCBI) 29904
Atlas_Id 40411
Location 16p12.2  [Link to chromosome band 16p12]
Location_base_pair Starts at 22206271 and ends at 22288745 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EEF2K (16p12.2) / C10orf35 (10q22.1)EEF2K (16p12.2) / UQCRC2 (16p12.2)EEF2K (16p12.2) / VWA3A (16p12.2)
EEF2K 16p12.2 / C10orf35 10q22.1EEF2K 16p12.2 / UQCRC2 16p12.2EEF2K 16p12.2 / VWA3A 16p12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EEF2K   24615
Cards
Entrez_Gene (NCBI)EEF2K  29904  eukaryotic elongation factor 2 kinase
AliasesHSU93850; eEF-2K
GeneCards (Weizmann)EEF2K
Ensembl hg19 (Hinxton)ENSG00000103319 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103319 [Gene_View]  chr16:22206271-22288745 [Contig_View]  EEF2K [Vega]
ICGC DataPortalENSG00000103319
TCGA cBioPortalEEF2K
AceView (NCBI)EEF2K
Genatlas (Paris)EEF2K
WikiGenes29904
SOURCE (Princeton)EEF2K
Genetics Home Reference (NIH)EEF2K
Genomic and cartography
GoldenPath hg38 (UCSC)EEF2K  -     chr16:22206271-22288745 +  16p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EEF2K  -     16p12.2   [Description]    (hg19-Feb_2009)
EnsemblEEF2K - 16p12.2 [CytoView hg19]  EEF2K - 16p12.2 [CytoView hg38]
Mapping of homologs : NCBIEEF2K [Mapview hg19]  EEF2K [Mapview hg38]
OMIM606968   
Gene and transcription
Genbank (Entrez)AK022569 AK308757 AW675420 BC032665 CA397138
RefSeq transcript (Entrez)NM_013302
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EEF2K
Cluster EST : UnigeneHs.498892 [ NCBI ]
CGAP (NCI)Hs.498892
Alternative Splicing GalleryENSG00000103319
Gene ExpressionEEF2K [ NCBI-GEO ]   EEF2K [ EBI - ARRAY_EXPRESS ]   EEF2K [ SEEK ]   EEF2K [ MEM ]
Gene Expression Viewer (FireBrowse)EEF2K [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29904
GTEX Portal (Tissue expression)EEF2K
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00418   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00418  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00418
Splice isoforms : SwissVarO00418
Catalytic activity : Enzyme2.7.11.20 [ Enzyme-Expasy ]   2.7.11.202.7.11.20 [ IntEnz-EBI ]   2.7.11.20 [ BRENDA ]   2.7.11.20 [ KEGG ]   
PhosPhoSitePlusO00418
Domaine pattern : Prosite (Expaxy)ALPHA_KINASE (PS51158)   
Domains : Interpro (EBI)eEF-2K    Kinase-like_dom    MHCK_EF2_kinase    Sel1-like    TPR-like_helical_dom   
Domain families : Pfam (Sanger)Alpha_kinase (PF02816)    Sel1 (PF08238)   
Domain families : Pfam (NCBI)pfam02816    pfam08238   
Domain families : Smart (EMBL)Alpha_kinase (SM00811)  
Conserved Domain (NCBI)EEF2K
DMDM Disease mutations29904
Blocks (Seattle)EEF2K
PDB (SRS)5J8H    5KS5   
PDB (PDBSum)5J8H    5KS5   
PDB (IMB)5J8H    5KS5   
PDB (RSDB)5J8H    5KS5   
Structural Biology KnowledgeBase5J8H    5KS5   
SCOP (Structural Classification of Proteins)5J8H    5KS5   
CATH (Classification of proteins structures)5J8H    5KS5   
SuperfamilyO00418
Human Protein AtlasENSG00000103319
Peptide AtlasO00418
HPRD07369
IPIIPI00011689   
Protein Interaction databases
DIP (DOE-UCLA)O00418
IntAct (EBI)O00418
FunCoupENSG00000103319
BioGRIDEEF2K
STRING (EMBL)EEF2K
ZODIACEEF2K
Ontologies - Pathways
QuickGOO00418
Ontology : AmiGOresponse to ischemia  protein kinase activity  elongation factor-2 kinase activity  calcium ion binding  calmodulin binding  ATP binding  cytoplasm  cytosol  translational elongation  translation factor activity, RNA binding  postsynaptic density  regulation of protein autophosphorylation  cellular response to insulin stimulus  negative regulation of apoptotic process  positive regulation of endocytosis  protein autophosphorylation  positive regulation of synapse assembly  positive regulation of dendritic spine morphogenesis  cellular response to calcium ion  cellular response to cAMP  cellular response to anoxia  cellular response to brain-derived neurotrophic factor stimulus  response to prolactin  
Ontology : EGO-EBIresponse to ischemia  protein kinase activity  elongation factor-2 kinase activity  calcium ion binding  calmodulin binding  ATP binding  cytoplasm  cytosol  translational elongation  translation factor activity, RNA binding  postsynaptic density  regulation of protein autophosphorylation  cellular response to insulin stimulus  negative regulation of apoptotic process  positive regulation of endocytosis  protein autophosphorylation  positive regulation of synapse assembly  positive regulation of dendritic spine morphogenesis  cellular response to calcium ion  cellular response to cAMP  cellular response to anoxia  cellular response to brain-derived neurotrophic factor stimulus  response to prolactin  
Pathways : BIOCARTAEukaryotic protein translation [Genes]   
NDEx NetworkEEF2K
Atlas of Cancer Signalling NetworkEEF2K
Wikipedia pathwaysEEF2K
Orthology - Evolution
OrthoDB29904
GeneTree (enSembl)ENSG00000103319
Phylogenetic Trees/Animal Genes : TreeFamEEF2K
HOVERGENO00418
HOGENOMO00418
Homologs : HomoloGeneEEF2K
Homology/Alignments : Family Browser (UCSC)EEF2K
Gene fusions - Rearrangements
Fusion : MitelmanEEF2K/C10orf35 [16p12.2/10q22.1]  
Fusion : MitelmanEEF2K/UQCRC2 [16p12.2/16p12.2]  [t(16;16)(p12;p12)]  
Fusion : MitelmanEEF2K/VWA3A [16p12.2/16p12.2]  [t(16;16)(p12;p12)]  
Fusion: TCGAEEF2K 16p12.2 C10orf35 10q22.1 LUSC
Fusion: TCGAEEF2K 16p12.2 UQCRC2 16p12.2 BRCA
Fusion: TCGAEEF2K 16p12.2 VWA3A 16p12.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEEF2K [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEF2K
dbVarEEF2K
ClinVarEEF2K
1000_GenomesEEF2K 
Exome Variant ServerEEF2K
ExAC (Exome Aggregation Consortium)EEF2K (select the gene name)
Genetic variants : HAPMAP29904
Genomic Variants (DGV)EEF2K [DGVbeta]
DECIPHEREEF2K [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEEF2K 
Mutations
ICGC Data PortalEEF2K 
TCGA Data PortalEEF2K 
Broad Tumor PortalEEF2K
OASIS PortalEEF2K [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEEF2K  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEEF2K
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EEF2K
DgiDB (Drug Gene Interaction Database)EEF2K
DoCM (Curated mutations)EEF2K (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEF2K (select a term)
intoGenEEF2K
Cancer3DEEF2K(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606968   
Orphanet
MedgenEEF2K
Genetic Testing Registry EEF2K
NextProtO00418 [Medical]
TSGene29904
GENETestsEEF2K
Target ValidationEEF2K
Huge Navigator EEF2K [HugePedia]
snp3D : Map Gene to Disease29904
BioCentury BCIQEEF2K
ClinGenEEF2K
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29904
Chemical/Pharm GKB GenePA134992891
Clinical trialEEF2K
Miscellaneous
canSAR (ICR)EEF2K (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEEF2K
EVEXEEF2K
GoPubMedEEF2K
iHOPEEF2K
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:32:09 CEST 2017

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