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EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA-specific)

Identity

Alias_symbol (synonym)SELB
EFSEC
eEFSec
Other alias
HGNC (Hugo) EEFSEC
LocusID (NCBI) 60678
Atlas_Id 47554
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 127872300 and ends at 128127489 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EEFSEC (3q21.3) / RPS27A (2p16.1)KMT2A (11q23.3) / EEFSEC (3q21.3)UBAP2L (1q21.3) / EEFSEC (3q21.3)
KMT2A 11q23.3 / EEFSEC 3q21.3UBAP2L 1q21.3 / EEFSEC 3q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;11)(q21;q23) KMT2A/EEFSEC


External links

Nomenclature
HGNC (Hugo)EEFSEC   24614
Cards
Entrez_Gene (NCBI)EEFSEC  60678  eukaryotic elongation factor, selenocysteine-tRNA-specific
AliasesEFSEC; SELB
GeneCards (Weizmann)EEFSEC
Ensembl hg19 (Hinxton)ENSG00000132394 [Gene_View]  chr3:127872300-128127489 [Contig_View]  EEFSEC [Vega]
Ensembl hg38 (Hinxton)ENSG00000132394 [Gene_View]  chr3:127872300-128127489 [Contig_View]  EEFSEC [Vega]
ICGC DataPortalENSG00000132394
TCGA cBioPortalEEFSEC
AceView (NCBI)EEFSEC
Genatlas (Paris)EEFSEC
WikiGenes60678
SOURCE (Princeton)EEFSEC
Genetics Home Reference (NIH)EEFSEC
Genomic and cartography
GoldenPath hg19 (UCSC)EEFSEC  -     chr3:127872300-128127489 +  3q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EEFSEC  -     3q21.3   [Description]    (hg38-Dec_2013)
EnsemblEEFSEC - 3q21.3 [CytoView hg19]  EEFSEC - 3q21.3 [CytoView hg38]
Mapping of homologs : NCBIEEFSEC [Mapview hg19]  EEFSEC [Mapview hg38]
OMIM607695   
Gene and transcription
Genbank (Entrez)AF268872 BC007933 BG420135 DB454660 DQ893258
RefSeq transcript (Entrez)NM_021937
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)EEFSEC
Cluster EST : UnigeneHs.477498 [ NCBI ]
CGAP (NCI)Hs.477498
Alternative Splicing GalleryENSG00000132394
Gene ExpressionEEFSEC [ NCBI-GEO ]   EEFSEC [ EBI - ARRAY_EXPRESS ]   EEFSEC [ SEEK ]   EEFSEC [ MEM ]
Gene Expression Viewer (FireBrowse)EEFSEC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60678
GTEX Portal (Tissue expression)EEFSEC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57772   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57772  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57772
Splice isoforms : SwissVarP57772
PhosPhoSitePlusP57772
Domaine pattern : Prosite (Expaxy)G_TR_2 (PS51722)   
Domains : Interpro (EBI)P-loop_NTPase    TF_GTP-bd_dom    Transl_B-barrel   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)EEFSEC
DMDM Disease mutations60678
Blocks (Seattle)EEFSEC
SuperfamilyP57772
Human Protein AtlasENSG00000132394
Peptide AtlasP57772
HPRD07409
IPIIPI00028050   IPI00789634   
Protein Interaction databases
DIP (DOE-UCLA)P57772
IntAct (EBI)P57772
FunCoupENSG00000132394
BioGRIDEEFSEC
STRING (EMBL)EEFSEC
ZODIACEEFSEC
Ontologies - Pathways
QuickGOP57772
Ontology : AmiGOtRNA binding  selenocysteine incorporation  translation elongation factor activity  GTPase activity  GTP binding  intracellular  nucleus  mitochondrion  translation  intracellular ribonucleoprotein complex  selenocysteine insertion sequence binding  ribonucleoprotein complex binding  
Ontology : EGO-EBItRNA binding  selenocysteine incorporation  translation elongation factor activity  GTPase activity  GTP binding  intracellular  nucleus  mitochondrion  translation  intracellular ribonucleoprotein complex  selenocysteine insertion sequence binding  ribonucleoprotein complex binding  
NDEx NetworkEEFSEC
Atlas of Cancer Signalling NetworkEEFSEC
Wikipedia pathwaysEEFSEC
Orthology - Evolution
OrthoDB60678
GeneTree (enSembl)ENSG00000132394
Phylogenetic Trees/Animal Genes : TreeFamEEFSEC
HOVERGENP57772
HOGENOMP57772
Homologs : HomoloGeneEEFSEC
Homology/Alignments : Family Browser (UCSC)EEFSEC
Gene fusions - Rearrangements
Fusion : MitelmanUBAP2L/EEFSEC [1q21.3/3q21.3]  [t(1;3)(q21;q21)]  
Fusion: TCGAUBAP2L 1q21.3 EEFSEC 3q21.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEEFSEC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EEFSEC
dbVarEEFSEC
ClinVarEEFSEC
1000_GenomesEEFSEC 
Exome Variant ServerEEFSEC
ExAC (Exome Aggregation Consortium)EEFSEC (select the gene name)
Genetic variants : HAPMAP60678
Genomic Variants (DGV)EEFSEC [DGVbeta]
DECIPHER (Syndromes)3:127872300-128127489  ENSG00000132394
CONAN: Copy Number AnalysisEEFSEC 
Mutations
ICGC Data PortalEEFSEC 
TCGA Data PortalEEFSEC 
Broad Tumor PortalEEFSEC
OASIS PortalEEFSEC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEEFSEC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEEFSEC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch EEFSEC
DgiDB (Drug Gene Interaction Database)EEFSEC
DoCM (Curated mutations)EEFSEC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EEFSEC (select a term)
intoGenEEFSEC
Cancer3DEEFSEC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607695   
Orphanet
MedgenEEFSEC
Genetic Testing Registry EEFSEC
NextProtP57772 [Medical]
TSGene60678
GENETestsEEFSEC
Huge Navigator EEFSEC [HugePedia]
snp3D : Map Gene to Disease60678
BioCentury BCIQEEFSEC
ClinGenEEFSEC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD60678
Chemical/Pharm GKB GenePA142671916
Clinical trialEEFSEC
Miscellaneous
canSAR (ICR)EEFSEC (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEEFSEC
EVEXEEFSEC
GoPubMedEEFSEC
iHOPEEFSEC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:59:44 CEST 2017

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