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EFNA1 (ephrin-A1)

Identity

Other namesB61
ECKLG
EFL1
EPLG1
LERK-1
LERK1
TNFAIP4
HGNC (Hugo) EFNA1
LocusID (NCBI) 1942
Location 1q22
Location_base_pair Starts at 155100349 and ends at 155107386 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EFNA1   3221
Entrez_Gene (NCBI)EFNA1  1942  ephrin-A1
Cards
GeneCards (Weizmann)EFNA1
Ensembl (Hinxton)ENSG00000169242 [Gene_View]  chr1:155100349-155107386 [Contig_View]  EFNA1 [Vega]
AceView (NCBI)EFNA1
Genatlas (Paris)EFNA1
SOURCE (Stanford)NM_004428 NM_182685
Genomic and cartography
GoldenPath (UCSC)EFNA1  -  1q22   chr1:155100349-155107386 +  1q22   [Description]    (hg19-Feb_2009)
EnsemblEFNA1 - 1q22 [CytoView]
Mapping of homologs : NCBIEFNA1 [Mapview]
OMIM191164   
Gene and transcription
Genbank (Entrez)AK057845 AK289589 AK313117 AL833641 AW274944
RefSeq transcript (SRS)NM_004428 NM_182685
RefSeq transcript (Entrez)NM_004428 NM_182685
RefSeq genomic (SRS)AC_000133 NC_000001 NC_018912 NT_004487 NW_001838531 NW_004077999
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_004487 NW_001838531 NW_004077999
Consensus coding sequences : CCDS (NCBI)EFNA1
Cluster EST : UnigeneHs.516664 [ SRS ] Hs.516664 [ NCBI ]
CGAP (NCI)Hs.516664
Alternative Splicing : Fast-db (Paris)GSHG0001017
Alternative Splicing GalleryENSG00000169242
Gene ExpressionEFNA1 [ NCBI-GEO ]   EFNA1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20827 (SRS) P20827 (Uniprot)
NextProtP20827
With graphics : InterProP20827
Splice isoforms : SwissVarP20827(Swissvar)
Domaine pattern : Prosite (SRS)EPHRIN_RBD_1 (PS01299)    EPHRIN_RBD_2 (PS51551)   
Domaine pattern : Prosite (Expaxy)EPHRIN_RBD_1 (PS01299)    EPHRIN_RBD_2 (PS51551)   
Domains : Interpro (SRS)Cupredoxin    Ephrin    Ephrin_CS   
Domains : Interpro (EBI)Cupredoxin    Ephrin    Ephrin_CS   
Related proteins : CluSTrP20827
Domain families : Pfam (SRS)Ephrin (PF00812)   
Domain families : Pfam (Sanger)Ephrin (PF00812)   
Domain families : Pfam (NCBI)pfam00812   
Domain structure : Prodom (Prabi Lyon)Ephrin (PD002533)   
DMDM1942
Blocks (Seattle)P20827
PDB (SRS)3CZU    3HEI    3MBW   
PDB (PDBSum)3CZU    3HEI    3MBW   
PDB (IMB)3CZU    3HEI    3MBW   
PDB (RSDB)3CZU    3HEI    3MBW   
Human Protein AtlasENSG00000169242
HPRD01858
IPIIPI00025840   IPI00377015   IPI00921580   
Protein Interaction databases
DIP (DOE-UCLA)P20827
IntAct (EBI)P20827
FunCoupENSG00000169242
REACTOMEEFNA1
Protein Interaction Database1942
BioGRIDEFNA1
InParanoidP20827
Interologous Interaction database P20827
IntegromeDBEFNA1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EFNA1
SNP (GeneSNP Utah)EFNA1
SNP : HGBaseEFNA1
Genetic variants : HAPMAPEFNA1
Somatic Mutations in Cancer : COSMICEFNA1 
CONAN: Copy Number AnalysisEFNA1 
Mutations and Diseases : HGMDEFNA1
OMIM191164   
GENETests191164   
Disease Genetic AssociationEFNA1
Huge Navigator EFNA1 [HugePedia]  EFNA1 [HugeCancerGEM]
Genomic VariantsEFNA1  EFNA1 [DGVbeta]
snp3D : Map Gene to Disease1942
General knowledge
Homologs : HomoloGeneEFNA1
Homology/Alignments : Family Browser (UCSC)EFNA1
Phylogenetic Trees/Animal Genes : TreeFamEFNA1
Chemical/Protein Interactions : CTD1942
Chemical/Pharm GKB GenePA27656
Clinical trialEFNA1
Cancer Resource (Charite)ENSG00000169242
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  angiogenesis  aortic valve morphogenesis  mitral valve morphogenesis  endocardial cushion to mesenchymal transition involved in heart valve formation  receptor binding  protein binding  extracellular region  integral to plasma membrane  cell-cell signaling  negative regulation of epithelial to mesenchymal transition  notochord formation  cell migration  neuron differentiation  regulation of cell adhesion mediated by integrin  substrate adhesion-dependent cell spreading  regulation of blood vessel endothelial cell migration  regulation of angiogenesis  anchored to plasma membrane  ephrin receptor binding  ephrin receptor signaling pathway  regulation of peptidyl-tyrosine phosphorylation  positive regulation of peptidyl-tyrosine phosphorylation  regulation of axonogenesis  negative regulation of dendritic spine morphogenesis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  angiogenesis  aortic valve morphogenesis  mitral valve morphogenesis  endocardial cushion to mesenchymal transition involved in heart valve formation  receptor binding  protein binding  extracellular region  integral to plasma membrane  cell-cell signaling  negative regulation of epithelial to mesenchymal transition  notochord formation  cell migration  neuron differentiation  regulation of cell adhesion mediated by integrin  substrate adhesion-dependent cell spreading  regulation of blood vessel endothelial cell migration  regulation of angiogenesis  anchored to plasma membrane  ephrin receptor binding  ephrin receptor signaling pathway  regulation of peptidyl-tyrosine phosphorylation  positive regulation of peptidyl-tyrosine phosphorylation  regulation of axonogenesis  negative regulation of dendritic spine morphogenesis  
Pathways : KEGGAxon guidance
Other databases
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
PubGeneEFNA1
iHOPEFNA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:44:43 CEST 2013
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