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EFNA2 (ephrin A2)

Identity

Alias_namesEPLG6
ephrin-A2
Alias_symbol (synonym)ELF-1
LERK6
Other aliasHEK7-L
LERK-6
HGNC (Hugo) EFNA2
LocusID (NCBI) 1943
Atlas_Id 40413
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1286153 and ends at 1301429 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EFNA2 (19p13.3) / EFNA2 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EFNA2   3222
Cards
Entrez_Gene (NCBI)EFNA2  1943  ephrin A2
AliasesELF-1; EPLG6; HEK7-L; LERK-6; 
LERK6
GeneCards (Weizmann)EFNA2
Ensembl hg19 (Hinxton)ENSG00000099617 [Gene_View]  chr19:1286153-1301429 [Contig_View]  EFNA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000099617 [Gene_View]  chr19:1286153-1301429 [Contig_View]  EFNA2 [Vega]
ICGC DataPortalENSG00000099617
TCGA cBioPortalEFNA2
AceView (NCBI)EFNA2
Genatlas (Paris)EFNA2
WikiGenes1943
SOURCE (Princeton)EFNA2
Genetics Home Reference (NIH)EFNA2
Genomic and cartography
GoldenPath hg19 (UCSC)EFNA2  -     chr19:1286153-1301429 +  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EFNA2  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblEFNA2 - 19p13.3 [CytoView hg19]  EFNA2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIEFNA2 [Mapview hg19]  EFNA2 [Mapview hg38]
OMIM602756   
Gene and transcription
Genbank (Entrez)AJ007292 BC146278 BC148727
RefSeq transcript (Entrez)NM_001405
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)EFNA2
Cluster EST : UnigeneHs.741510 [ NCBI ]
CGAP (NCI)Hs.741510
Alternative Splicing GalleryENSG00000099617
Gene ExpressionEFNA2 [ NCBI-GEO ]   EFNA2 [ EBI - ARRAY_EXPRESS ]   EFNA2 [ SEEK ]   EFNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)EFNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1943
GTEX Portal (Tissue expression)EFNA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43921   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43921  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43921
Splice isoforms : SwissVarO43921
PhosPhoSitePlusO43921
Domaine pattern : Prosite (Expaxy)EPHRIN_RBD_1 (PS01299)    EPHRIN_RBD_2 (PS51551)   
Domains : Interpro (EBI)Cupredoxin    Ephrin    Ephrin_CS    Ephrin_RBD   
Domain families : Pfam (Sanger)Ephrin (PF00812)   
Domain families : Pfam (NCBI)pfam00812   
Domain structure : Prodom (Prabi Lyon)Ephrin (PD002533)   
Conserved Domain (NCBI)EFNA2
DMDM Disease mutations1943
Blocks (Seattle)EFNA2
PDB (SRS)2WO3   
PDB (PDBSum)2WO3   
PDB (IMB)2WO3   
PDB (RSDB)2WO3   
Structural Biology KnowledgeBase2WO3   
SCOP (Structural Classification of Proteins)2WO3   
CATH (Classification of proteins structures)2WO3   
SuperfamilyO43921
Human Protein AtlasENSG00000099617
Peptide AtlasO43921
HPRD04132
IPIIPI00015159   
Protein Interaction databases
DIP (DOE-UCLA)O43921
IntAct (EBI)O43921
FunCoupENSG00000099617
BioGRIDEFNA2
STRING (EMBL)EFNA2
ZODIACEFNA2
Ontologies - Pathways
QuickGOO43921
Ontology : AmiGOextracellular region  plasma membrane  plasma membrane  cell-cell signaling  axon guidance  olfactory bulb development  osteoclast differentiation  osteoclast differentiation  anchored component of membrane  neuromuscular junction  perikaryon  bone remodeling  bone remodeling  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  ephrin receptor signaling pathway  
Ontology : EGO-EBIextracellular region  plasma membrane  plasma membrane  cell-cell signaling  axon guidance  olfactory bulb development  osteoclast differentiation  osteoclast differentiation  anchored component of membrane  neuromuscular junction  perikaryon  bone remodeling  bone remodeling  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  ephrin receptor signaling pathway  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Axon guidance   
NDEx NetworkEFNA2
Atlas of Cancer Signalling NetworkEFNA2
Wikipedia pathwaysEFNA2
Orthology - Evolution
OrthoDB1943
GeneTree (enSembl)ENSG00000099617
Phylogenetic Trees/Animal Genes : TreeFamEFNA2
HOVERGENO43921
HOGENOMO43921
Homologs : HomoloGeneEFNA2
Homology/Alignments : Family Browser (UCSC)EFNA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEFNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EFNA2
dbVarEFNA2
ClinVarEFNA2
1000_GenomesEFNA2 
Exome Variant ServerEFNA2
ExAC (Exome Aggregation Consortium)EFNA2 (select the gene name)
Genetic variants : HAPMAP1943
Genomic Variants (DGV)EFNA2 [DGVbeta]
DECIPHER (Syndromes)19:1286153-1301429  ENSG00000099617
CONAN: Copy Number AnalysisEFNA2 
Mutations
ICGC Data PortalEFNA2 
TCGA Data PortalEFNA2 
Broad Tumor PortalEFNA2
OASIS PortalEFNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEFNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEFNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EFNA2
DgiDB (Drug Gene Interaction Database)EFNA2
DoCM (Curated mutations)EFNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EFNA2 (select a term)
intoGenEFNA2
Cancer3DEFNA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602756   
Orphanet
MedgenEFNA2
Genetic Testing Registry EFNA2
NextProtO43921 [Medical]
TSGene1943
GENETestsEFNA2
Huge Navigator EFNA2 [HugePedia]
snp3D : Map Gene to Disease1943
BioCentury BCIQEFNA2
ClinGenEFNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1943
Chemical/Pharm GKB GenePA27657
Clinical trialEFNA2
Miscellaneous
canSAR (ICR)EFNA2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEFNA2
EVEXEFNA2
GoPubMedEFNA2
iHOPEFNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:59:46 CEST 2017

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