Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EFNA3 (ephrin A3)

Identity

Alias_namesEPLG3
ephrin-A3
Alias_symbol (synonym)LERK3
Ehk1-L
Other aliasEFL2
HGNC (Hugo) EFNA3
LocusID (NCBI) 1944
Atlas_Id 53933
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 155078872 and ends at 155087538 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EFNA3 (1q22) / FLAD1 (1q21.3)EFNA3 (1q22) / HFE2 (1q21.1)EFNA3 (1q22) / PIK3C2G (12p12.3)
EFNA3 (1q22) / USP21 (1q23.3)EFNA3 1q22 / FLAD1 1q21.3EFNA3 1q22 / HFE2 1q21.1
EFNA3 1q22 / USP21 1q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EFNA3   3223
Cards
Entrez_Gene (NCBI)EFNA3  1944  ephrin A3
AliasesEFL2; EPLG3; Ehk1-L; LERK3
GeneCards (Weizmann)EFNA3
Ensembl hg19 (Hinxton)ENSG00000143590 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143590 [Gene_View]  chr1:155078872-155087538 [Contig_View]  EFNA3 [Vega]
ICGC DataPortalENSG00000143590
TCGA cBioPortalEFNA3
AceView (NCBI)EFNA3
Genatlas (Paris)EFNA3
WikiGenes1944
SOURCE (Princeton)EFNA3
Genetics Home Reference (NIH)EFNA3
Genomic and cartography
GoldenPath hg38 (UCSC)EFNA3  -     chr1:155078872-155087538 +  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EFNA3  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblEFNA3 - 1q21.3 [CytoView hg19]  EFNA3 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIEFNA3 [Mapview hg19]  EFNA3 [Mapview hg38]
OMIM601381   
Gene and transcription
Genbank (Entrez)AK296030 AK316248 BC017722 BC110406 BU633345
RefSeq transcript (Entrez)NM_004952
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EFNA3
Cluster EST : UnigeneHs.516656 [ NCBI ]
CGAP (NCI)Hs.516656
Alternative Splicing GalleryENSG00000143590
Gene ExpressionEFNA3 [ NCBI-GEO ]   EFNA3 [ EBI - ARRAY_EXPRESS ]   EFNA3 [ SEEK ]   EFNA3 [ MEM ]
Gene Expression Viewer (FireBrowse)EFNA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1944
GTEX Portal (Tissue expression)EFNA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52797   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52797  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52797
Splice isoforms : SwissVarP52797
PhosPhoSitePlusP52797
Domaine pattern : Prosite (Expaxy)EPHRIN_RBD_1 (PS01299)    EPHRIN_RBD_2 (PS51551)   
Domains : Interpro (EBI)Cupredoxin    Ephrin    Ephrin-A_Ecto    Ephrin_CS    Ephrin_RBD   
Domain families : Pfam (Sanger)Ephrin (PF00812)   
Domain families : Pfam (NCBI)pfam00812   
Domain structure : Prodom (Prabi Lyon)Ephrin (PD002533)   
Conserved Domain (NCBI)EFNA3
DMDM Disease mutations1944
Blocks (Seattle)EFNA3
SuperfamilyP52797
Human Protein AtlasENSG00000143590
Peptide AtlasP52797
HPRD03225
IPIIPI00005123   IPI00910631   IPI00910056   
Protein Interaction databases
DIP (DOE-UCLA)P52797
IntAct (EBI)P52797
FunCoupENSG00000143590
BioGRIDEFNA3
STRING (EMBL)EFNA3
ZODIACEFNA3
Ontologies - Pathways
QuickGOP52797
Ontology : AmiGOtransmembrane-ephrin receptor activity  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  cell-cell signaling  anchored component of membrane  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  
Ontology : EGO-EBItransmembrane-ephrin receptor activity  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  cell-cell signaling  anchored component of membrane  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Axon guidance    MicroRNAs in cancer   
NDEx NetworkEFNA3
Atlas of Cancer Signalling NetworkEFNA3
Wikipedia pathwaysEFNA3
Orthology - Evolution
OrthoDB1944
GeneTree (enSembl)ENSG00000143590
Phylogenetic Trees/Animal Genes : TreeFamEFNA3
HOVERGENP52797
HOGENOMP52797
Homologs : HomoloGeneEFNA3
Homology/Alignments : Family Browser (UCSC)EFNA3
Gene fusions - Rearrangements
Fusion : MitelmanEFNA3/FLAD1 [1q22/1q21.3]  
Fusion : MitelmanEFNA3/HFE2 [1q22/1q21.1]  [t(1;1)(q21;q22)]  
Fusion : MitelmanEFNA3/USP21 [1q22/1q23.3]  [t(1;1)(q22;q23)]  
Fusion: TCGAEFNA3 1q22 FLAD1 1q21.3 LUSC
Fusion: TCGAEFNA3 1q22 HFE2 1q21.1 LUAD
Fusion: TCGAEFNA3 1q22 USP21 1q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEFNA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EFNA3
dbVarEFNA3
ClinVarEFNA3
1000_GenomesEFNA3 
Exome Variant ServerEFNA3
ExAC (Exome Aggregation Consortium)EFNA3 (select the gene name)
Genetic variants : HAPMAP1944
Genomic Variants (DGV)EFNA3 [DGVbeta]
DECIPHEREFNA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEFNA3 
Mutations
ICGC Data PortalEFNA3 
TCGA Data PortalEFNA3 
Broad Tumor PortalEFNA3
OASIS PortalEFNA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEFNA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEFNA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EFNA3
DgiDB (Drug Gene Interaction Database)EFNA3
DoCM (Curated mutations)EFNA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EFNA3 (select a term)
intoGenEFNA3
Cancer3DEFNA3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601381   
Orphanet
MedgenEFNA3
Genetic Testing Registry EFNA3
NextProtP52797 [Medical]
TSGene1944
GENETestsEFNA3
Target ValidationEFNA3
Huge Navigator EFNA3 [HugePedia]
snp3D : Map Gene to Disease1944
BioCentury BCIQEFNA3
ClinGenEFNA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1944
Chemical/Pharm GKB GenePA27658
Clinical trialEFNA3
Miscellaneous
canSAR (ICR)EFNA3 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEFNA3
EVEXEFNA3
GoPubMedEFNA3
iHOPEFNA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:32:11 CEST 2017

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