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EFNA3 (ephrin A3)

Identity

Alias (NCBI)EFL2
EPLG3
Ehk1-L
LERK3
HGNC (Hugo) EFNA3
HGNC Alias symbLERK3
Ehk1-L
HGNC Alias nameEPH-related receptor tyrosine kinase ligand 3
HGNC Previous nameEPLG3
HGNC Previous nameephrin-A3
LocusID (NCBI) 1944
Atlas_Id 53933
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 155078837 and ends at 155087538 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EFNA3 (1q22) / FLAD1 (1q21.3)EFNA3 (1q22) / HFE2 (1q21.1)EFNA3 (1q22) / PIK3C2G (12p12.3)
EFNA3 (1q22) / USP21 (1q23.3)EFNA3 1q22 / FLAD1 1q21.3EFNA3 1q22 / HFE2 1q21.1
EFNA3 1q22 / USP21 1q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EFNA3   3223
Cards
Entrez_Gene (NCBI)EFNA3    ephrin A3
AliasesEFL2; EPLG3; Ehk1-L; LERK3
GeneCards (Weizmann)EFNA3
Ensembl hg19 (Hinxton)ENSG00000143590 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143590 [Gene_View]  ENSG00000143590 [Sequence]  chr1:155078837-155087538 [Contig_View]  EFNA3 [Vega]
ICGC DataPortalENSG00000143590
TCGA cBioPortalEFNA3
AceView (NCBI)EFNA3
Genatlas (Paris)EFNA3
SOURCE (Princeton)EFNA3
Genetics Home Reference (NIH)EFNA3
Genomic and cartography
GoldenPath hg38 (UCSC)EFNA3  -     chr1:155078837-155087538 +  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EFNA3  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathEFNA3 - 1q21.3 [CytoView hg19]  EFNA3 - 1q21.3 [CytoView hg38]
ImmunoBaseENSG00000143590
Genome Data Viewer NCBIEFNA3 [Mapview hg19]  
OMIM601381   
Gene and transcription
Genbank (Entrez)AK296030 AK316248 BC017722 BC110406 BU633345
RefSeq transcript (Entrez)NM_004952
Consensus coding sequences : CCDS (NCBI)EFNA3
Gene ExpressionEFNA3 [ NCBI-GEO ]   EFNA3 [ EBI - ARRAY_EXPRESS ]   EFNA3 [ SEEK ]   EFNA3 [ MEM ]
Gene Expression Viewer (FireBrowse)EFNA3 [ Firebrowse - Broad ]
GenevisibleExpression of EFNA3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1944
GTEX Portal (Tissue expression)EFNA3
Human Protein AtlasENSG00000143590-EFNA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52797   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52797  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52797
PhosPhoSitePlusP52797
Domaine pattern : Prosite (Expaxy)EPHRIN_RBD_1 (PS01299)    EPHRIN_RBD_2 (PS51551)   
Domains : Interpro (EBI)Cupredoxin    Ephrin    Ephrin-A_Ecto    Ephrin_CS    Ephrin_RBD   
Domain families : Pfam (Sanger)Ephrin (PF00812)   
Domain families : Pfam (NCBI)pfam00812   
Conserved Domain (NCBI)EFNA3
SuperfamilyP52797
AlphaFold pdb e-kbP52797   
Human Protein Atlas [tissue]ENSG00000143590-EFNA3 [tissue]
HPRD03225
Protein Interaction databases
DIP (DOE-UCLA)P52797
IntAct (EBI)P52797
BioGRIDEFNA3
STRING (EMBL)EFNA3
ZODIACEFNA3
Ontologies - Pathways
QuickGOP52797
Ontology : AmiGOtransmembrane-ephrin receptor activity  protein binding  plasma membrane  plasma membrane  plasma membrane  cell-cell signaling  axon guidance  negative regulation of angiogenesis  anchored component of membrane  intrinsic component of plasma membrane  ephrin receptor binding  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  ephrin receptor signaling pathway  ephrin receptor signaling pathway  positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  
Ontology : EGO-EBItransmembrane-ephrin receptor activity  protein binding  plasma membrane  plasma membrane  plasma membrane  cell-cell signaling  axon guidance  negative regulation of angiogenesis  anchored component of membrane  intrinsic component of plasma membrane  ephrin receptor binding  ephrin receptor binding  ephrin receptor signaling pathway  ephrin receptor signaling pathway  ephrin receptor signaling pathway  ephrin receptor signaling pathway  positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Axon guidance    MicroRNAs in cancer   
NDEx NetworkEFNA3
Atlas of Cancer Signalling NetworkEFNA3
Wikipedia pathwaysEFNA3
Orthology - Evolution
OrthoDB1944
GeneTree (enSembl)ENSG00000143590
Phylogenetic Trees/Animal Genes : TreeFamEFNA3
Homologs : HomoloGeneEFNA3
Homology/Alignments : Family Browser (UCSC)EFNA3
Gene fusions - Rearrangements
Fusion : MitelmanEFNA3/FLAD1 [1q22/1q21.3]  
Fusion : MitelmanEFNA3/HFE2 [1q22/1q21.1]  
Fusion : MitelmanEFNA3/USP21 [1q22/1q23.3]  
Fusion : QuiverEFNA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEFNA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EFNA3
dbVarEFNA3
ClinVarEFNA3
MonarchEFNA3
1000_GenomesEFNA3 
Exome Variant ServerEFNA3
GNOMAD BrowserENSG00000143590
Varsome BrowserEFNA3
ACMGEFNA3 variants
VarityP52797
Genomic Variants (DGV)EFNA3 [DGVbeta]
DECIPHEREFNA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEFNA3 
Mutations
ICGC Data PortalEFNA3 
TCGA Data PortalEFNA3 
Broad Tumor PortalEFNA3
OASIS PortalEFNA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEFNA3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEFNA3
Mutations and Diseases : HGMDEFNA3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEFNA3
DgiDB (Drug Gene Interaction Database)EFNA3
DoCM (Curated mutations)EFNA3
CIViC (Clinical Interpretations of Variants in Cancer)EFNA3
Cancer3DEFNA3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601381   
Orphanet
DisGeNETEFNA3
MedgenEFNA3
Genetic Testing Registry EFNA3
NextProtP52797 [Medical]
GENETestsEFNA3
Target ValidationEFNA3
Huge Navigator EFNA3 [HugePedia]
ClinGenEFNA3
Clinical trials, drugs, therapy
MyCancerGenomeEFNA3
Protein Interactions : CTDEFNA3
Pharm GKB GenePA27658
PharosP52797
Clinical trialEFNA3
Miscellaneous
canSAR (ICR)EFNA3
HarmonizomeEFNA3
DataMed IndexEFNA3
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEFNA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:07:45 CEST 2021

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