Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EGF (epidermal growth factor)

Identity

Alias_namesepidermal growth factor (beta-urogastrone)
Other aliasHOMG4
URG
HGNC (Hugo) EGF
LocusID (NCBI) 1950
Atlas_Id 198
Location 4q25  [Link to chromosome band 4q25]
Location_base_pair Starts at 110834040 and ends at 110934235 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AL359075.1 () / EGF (4q25)EGF (4q25) / IL18 (11q23.1)EGF (4q25) / NEAT1 (11q13.1)
IL18 (11q23.1) / EGF (4q25)AL359075.1 EGF 4q25

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Gallbladder: Intrahepatic cholangiocarcinoma


External links

Nomenclature
HGNC (Hugo)EGF   3229
Cards
Entrez_Gene (NCBI)EGF  1950  epidermal growth factor
AliasesHOMG4; URG
GeneCards (Weizmann)EGF
Ensembl hg19 (Hinxton)ENSG00000138798 [Gene_View]  chr4:110834040-110934235 [Contig_View]  EGF [Vega]
Ensembl hg38 (Hinxton)ENSG00000138798 [Gene_View]  chr4:110834040-110934235 [Contig_View]  EGF [Vega]
ICGC DataPortalENSG00000138798
TCGA cBioPortalEGF
AceView (NCBI)EGF
Genatlas (Paris)EGF
WikiGenes1950
SOURCE (Princeton)EGF
Genetics Home Reference (NIH)EGF
Genomic and cartography
GoldenPath hg19 (UCSC)EGF  -     chr4:110834040-110934235 +  4q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EGF  -     4q25   [Description]    (hg38-Dec_2013)
EnsemblEGF - 4q25 [CytoView hg19]  EGF - 4q25 [CytoView hg38]
Mapping of homologs : NCBIEGF [Mapview hg19]  EGF [Mapview hg38]
OMIM131530   611718   
Gene and transcription
Genbank (Entrez)AI628974 AK299306 AK307734 AY548762 BC093731
RefSeq transcript (Entrez)NM_001178130 NM_001178131 NM_001963
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_011441 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)EGF
Cluster EST : UnigeneHs.419815 [ NCBI ]
CGAP (NCI)Hs.419815
Alternative Splicing GalleryENSG00000138798
Gene ExpressionEGF [ NCBI-GEO ]   EGF [ EBI - ARRAY_EXPRESS ]   EGF [ SEEK ]   EGF [ MEM ]
Gene Expression Viewer (FireBrowse)EGF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1950
GTEX Portal (Tissue expression)EGF
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01133   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01133  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01133
Splice isoforms : SwissVarP01133
PhosPhoSitePlusP01133
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LDLRB (PS51120)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GFP-like    Growth_fac_rcpt_    LDLR_classB_rpt    Pro-epidermal_GF   
Domain families : Pfam (Sanger)EGF (PF00008)    EGF_CA (PF07645)    Ldl_recept_b (PF00058)   
Domain families : Pfam (NCBI)pfam00008    pfam07645    pfam00058   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  LY (SM00135)  
Conserved Domain (NCBI)EGF
DMDM Disease mutations1950
Blocks (Seattle)EGF
PDB (SRS)1IVO    1JL9    1NQL    1P9J    2KV4    3NJP   
PDB (PDBSum)1IVO    1JL9    1NQL    1P9J    2KV4    3NJP   
PDB (IMB)1IVO    1JL9    1NQL    1P9J    2KV4    3NJP   
PDB (RSDB)1IVO    1JL9    1NQL    1P9J    2KV4    3NJP   
Structural Biology KnowledgeBase1IVO    1JL9    1NQL    1P9J    2KV4    3NJP   
SCOP (Structural Classification of Proteins)1IVO    1JL9    1NQL    1P9J    2KV4    3NJP   
CATH (Classification of proteins structures)1IVO    1JL9    1NQL    1P9J    2KV4    3NJP   
SuperfamilyP01133
Human Protein AtlasENSG00000138798
Peptide AtlasP01133
HPRD00578
IPIIPI00000073   IPI00966866   IPI00967121   
Protein Interaction databases
DIP (DOE-UCLA)P01133
IntAct (EBI)P01133
FunCoupENSG00000138798
BioGRIDEGF
STRING (EMBL)EGF
ZODIACEGF
Ontologies - Pathways
QuickGOP01133
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  activation of MAPK activity  angiogenesis  platelet degranulation  protein tyrosine kinase activity  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  lysosomal membrane  plasma membrane  DNA replication  signal transduction  activation of transmembrane receptor protein tyrosine kinase activity  epidermal growth factor receptor signaling pathway  STAT protein import into nucleus  growth factor activity  positive regulation of cell proliferation  positive regulation of peptidyl-threonine phosphorylation  regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  Wnt-protein binding  peptidyl-tyrosine phosphorylation  positive regulation of cerebellar granule cell precursor proliferation  transmembrane receptor protein tyrosine kinase activator activity  platelet alpha granule lumen  positive regulation of catenin import into nucleus  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  positive regulation of phosphorylation  Wnt-activated receptor activity  receptor complex  positive regulation of DNA binding  positive regulation of MAP kinase activity  positive regulation of GTPase activity  Wnt signaling pathway involved in dorsal/ventral axis specification  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of mitotic nuclear division  positive regulation of transcription, DNA-templated  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  branching morphogenesis of an epithelial tube  negative regulation of secretion  canonical Wnt signaling pathway  mammary gland alveolus development  extracellular exosome  ERK1 and ERK2 cascade  regulation of calcium ion import  negative regulation of cholesterol efflux  positive regulation of hyaluronan biosynthetic process  regulation of protein localization to cell surface  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  regulation of cell motility  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  activation of MAPK activity  angiogenesis  platelet degranulation  protein tyrosine kinase activity  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  lysosomal membrane  plasma membrane  DNA replication  signal transduction  activation of transmembrane receptor protein tyrosine kinase activity  epidermal growth factor receptor signaling pathway  STAT protein import into nucleus  growth factor activity  positive regulation of cell proliferation  positive regulation of peptidyl-threonine phosphorylation  regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  Wnt-protein binding  peptidyl-tyrosine phosphorylation  positive regulation of cerebellar granule cell precursor proliferation  transmembrane receptor protein tyrosine kinase activator activity  platelet alpha granule lumen  positive regulation of catenin import into nucleus  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  positive regulation of phosphorylation  Wnt-activated receptor activity  receptor complex  positive regulation of DNA binding  positive regulation of MAP kinase activity  positive regulation of GTPase activity  Wnt signaling pathway involved in dorsal/ventral axis specification  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of mitotic nuclear division  positive regulation of transcription, DNA-templated  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  branching morphogenesis of an epithelial tube  negative regulation of secretion  canonical Wnt signaling pathway  mammary gland alveolus development  extracellular exosome  ERK1 and ERK2 cascade  regulation of calcium ion import  negative regulation of cholesterol efflux  positive regulation of hyaluronan biosynthetic process  regulation of protein localization to cell surface  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  regulation of cell motility  
Pathways : BIOCARTAKeratinocyte Differentiation [Genes]    CBL mediated ligand-induced downregulation of EGF receptors [Genes]    The role of FYVE-finger proteins in vesicle transport [Genes]    Map Kinase Inactivation of SMRT Corepressor [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    mCalpain and friends in Cell motility [Genes]    Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling [Genes]    EGF Signaling Pathway [Genes]    Sprouty regulation of tyrosine kinase signals [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Cytokine-cytokine receptor interaction    HIF-1 signaling pathway    FoxO signaling pathway    Endocytosis    PI3K-Akt signaling pathway    Focal adhesion    Gap junction    Regulation of actin cytoskeleton    Hepatitis C    Pathways in cancer    Pancreatic cancer    Endometrial cancer    Glioma    Prostate cancer    Melanoma    Bladder cancer    Non-small cell lung cancer   
NDEx NetworkEGF
Atlas of Cancer Signalling NetworkEGF
Wikipedia pathwaysEGF
Orthology - Evolution
OrthoDB1950
GeneTree (enSembl)ENSG00000138798
Phylogenetic Trees/Animal Genes : TreeFamEGF
HOVERGENP01133
HOGENOMP01133
Homologs : HomoloGeneEGF
Homology/Alignments : Family Browser (UCSC)EGF
Gene fusions - Rearrangements
Fusion: TCGAAL359075.1 EGF 4q25 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEGF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EGF
dbVarEGF
ClinVarEGF
1000_GenomesEGF 
Exome Variant ServerEGF
ExAC (Exome Aggregation Consortium)EGF (select the gene name)
Genetic variants : HAPMAP1950
Genomic Variants (DGV)EGF [DGVbeta]
DECIPHER (Syndromes)4:110834040-110934235  ENSG00000138798
CONAN: Copy Number AnalysisEGF 
Mutations
ICGC Data PortalEGF 
TCGA Data PortalEGF 
Broad Tumor PortalEGF
OASIS PortalEGF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEGF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEGF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EGF
DgiDB (Drug Gene Interaction Database)EGF
DoCM (Curated mutations)EGF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EGF (select a term)
intoGenEGF
Cancer3DEGF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131530    611718   
Orphanet18690    10345   
MedgenEGF
Genetic Testing Registry EGF
NextProtP01133 [Medical]
TSGene1950
GENETestsEGF
Huge Navigator EGF [HugePedia]
snp3D : Map Gene to Disease1950
BioCentury BCIQEGF
ClinGenEGF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1950
Chemical/Pharm GKB GenePA27664
Clinical trialEGF
Miscellaneous
canSAR (ICR)EGF (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEGF
EVEXEGF
GoPubMedEGF
iHOPEGF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:04:20 CET 2017

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