EGFL7 (EGF like domain multiple 7)

2008-12-01  

Identity

HGNC
EGFL7
LOCATION
9q34.3
LOCUSID
51162
ALIAS
NEU1,VE-STATIN,ZNEU1

Other Information

Locus ID:

NCBI: 51162
MIM: 608582
HGNC: 20594
Ensembl: ENSG00000172889

Variants:

dbSNP: 51162
ClinVar: 51162
TCGA: ENSG00000172889
COSMIC: EGFL7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172889ENST00000308874Q9UHF1
ENSG00000172889ENST00000308874A0A024R8F5
ENSG00000172889ENST00000371698Q9UHF1
ENSG00000172889ENST00000371698A0A024R8F5
ENSG00000172889ENST00000371699Q9UHF1
ENSG00000172889ENST00000371699A0A024R8F5
ENSG00000172889ENST00000406555Q9UHF1
ENSG00000172889ENST00000406555A0A024R8F5
ENSG00000172889ENST00000492862R4GMT3

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185218482008Deregulated expression of miR-106a predicts survival in human colon cancer patients.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
209535572010miR-126 and miR-126*: new players in cancer.79
191161452009Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.77
181931842008Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells.61
200344722010miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7.58
145929692003VE-statin, an endothelial repressor of smooth muscle cell migration.47
221603772012EGFL7: a unique angiogenic signaling factor in vascular development and disease.46
198240752009Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma.42
220378712011Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation.31

Citation

Dessen P

EGFL7 (EGF like domain multiple 7)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50572/egfl7