EGFR (epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian))

Identity

Other names	ERBB
	ERBB1
	HER1
	PIG61
	mENA
HGNC	EGFR
Location	7p12
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	EGFR   3236
Entrez_Gene	EGFR  1956  epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
	Cards
GeneCards	EGFR
Ensembl	EGFR [Search_View]   ENSG00000146648 [Gene_View]
Genatlas	EGFR
GeneLynx	EGFR
eGenome	EGFR
euGene	1956
	Genomic and cartography
GoldenPath	EGFR  -  7p12   chr7:55054219-55242525 +  7p11.2   [Description]    (hg18-March_2006)
Ensembl	EGFR - 7p11.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	EGFR
	Gene and transcription
Genbank	AB209442 [ ENTREZ ]
Genbank	AF125253 [ ENTREZ ]
Genbank	AF277897 [ ENTREZ ]
Genbank	AI217671 [ ENTREZ ]
Genbank	AK225422 [ ENTREZ ]
RefSeq	NM_005228 [ SRS ]    NM_005228 [ ENTREZ ]
RefSeq	NM_201282 [ SRS ]    NM_201282 [ ENTREZ ]
RefSeq	NM_201283 [ SRS ]    NM_201283 [ ENTREZ ]
RefSeq	NM_201284 [ SRS ]    NM_201284 [ ENTREZ ]
RefSeq	AC_000050 [ SRS ]    AC_000050 [ ENTREZ ]
RefSeq	AC_000068 [ SRS ]    AC_000068 [ ENTREZ ]
RefSeq	AC_000139 [ SRS ]    AC_000139 [ ENTREZ ]
RefSeq	NC_000007 [ SRS ]    NC_000007 [ ENTREZ ]
RefSeq	NG_007726 [ SRS ]    NG_007726 [ ENTREZ ]
RefSeq	NT_033968 [ SRS ]    NT_033968 [ ENTREZ ]
RefSeq	NT_079592 [ SRS ]    NT_079592 [ ENTREZ ]
RefSeq	NW_001839007 [ SRS ]    NW_001839007 [ ENTREZ ]
RefSeq	NW_923284 [ SRS ]    NW_923284 [ ENTREZ ]
AceView	EGFR AceView - NCBI
Unigene	Hs.488293 [ SRS ]    Hs.488293 [ NCBI ]     HS488293 [ spliceNest ]
Fast-db	5430 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P00533 [ SRS]    P00533 [ EXPASY ]     P00533 [ INTERPRO ]     P00533 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Interpro	IPR000494 EGF_rcpt_L [ SRS ]    IPR000494 EGF_rcpt_L [ EBI ]
Interpro	IPR006211 Furin-like [ SRS ]    IPR006211 Furin-like [ EBI ]
Interpro	IPR006212 Furin_repeat [ SRS ]    IPR006212 Furin_repeat [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR016245 Tyr_kinase_rcpt_EGF/ERB/XmrK [ SRS ]    IPR016245 Tyr_kinase_rcpt_EGF/ERB/XmrK [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
CluSTr	P00533
Pfam	PF00757 Furin-like [ SRS ]    PF00757 Furin-like [ Sanger ]    pfam00757 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Pfam	PF01030 Recep_L_domain [ SRS ]    PF01030 Recep_L_domain [ Sanger ]    pfam01030 [ NCBI-CDD ]
Smart	SM00261 FU [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P00533 EGFR_HUMAN [ Domain structure ]   P00533 EGFR_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P00533
PDB	1DNQ [ SRS ]    1DNQ [ PdbSum ],   1DNQ [ IMB ]   1DNQ [ RSDB ]
PDB	1DNR [ SRS ]    1DNR [ PdbSum ],   1DNR [ IMB ]   1DNR [ RSDB ]
PDB	1IVO [ SRS ]    1IVO [ PdbSum ],   1IVO [ IMB ]   1IVO [ RSDB ]
PDB	1M14 [ SRS ]    1M14 [ PdbSum ],   1M14 [ IMB ]   1M14 [ RSDB ]
PDB	1M17 [ SRS ]    1M17 [ PdbSum ],   1M17 [ IMB ]   1M17 [ RSDB ]
PDB	1MOX [ SRS ]    1MOX [ PdbSum ],   1MOX [ IMB ]   1MOX [ RSDB ]
PDB	1NQL [ SRS ]    1NQL [ PdbSum ],   1NQL [ IMB ]   1NQL [ RSDB ]
PDB	1XKK [ SRS ]    1XKK [ PdbSum ],   1XKK [ IMB ]   1XKK [ RSDB ]
PDB	1YY9 [ SRS ]    1YY9 [ PdbSum ],   1YY9 [ IMB ]   1YY9 [ RSDB ]
PDB	1Z9I [ SRS ]    1Z9I [ PdbSum ],   1Z9I [ IMB ]   1Z9I [ RSDB ]
PDB	2EB2 [ SRS ]    2EB2 [ PdbSum ],   2EB2 [ IMB ]   2EB2 [ RSDB ]
PDB	2EB3 [ SRS ]    2EB3 [ PdbSum ],   2EB3 [ IMB ]   2EB3 [ RSDB ]
PDB	2EXP [ SRS ]    2EXP [ PdbSum ],   2EXP [ IMB ]   2EXP [ RSDB ]
PDB	2EXQ [ SRS ]    2EXQ [ PdbSum ],   2EXQ [ IMB ]   2EXQ [ RSDB ]
PDB	2GS2 [ SRS ]    2GS2 [ PdbSum ],   2GS2 [ IMB ]   2GS2 [ RSDB ]
PDB	2GS6 [ SRS ]    2GS6 [ PdbSum ],   2GS6 [ IMB ]   2GS6 [ RSDB ]
PDB	2GS7 [ SRS ]    2GS7 [ PdbSum ],   2GS7 [ IMB ]   2GS7 [ RSDB ]
PDB	2ITN [ SRS ]    2ITN [ PdbSum ],   2ITN [ IMB ]   2ITN [ RSDB ]
PDB	2ITO [ SRS ]    2ITO [ PdbSum ],   2ITO [ IMB ]   2ITO [ RSDB ]
PDB	2ITP [ SRS ]    2ITP [ PdbSum ],   2ITP [ IMB ]   2ITP [ RSDB ]
PDB	2ITQ [ SRS ]    2ITQ [ PdbSum ],   2ITQ [ IMB ]   2ITQ [ RSDB ]
PDB	2ITT [ SRS ]    2ITT [ PdbSum ],   2ITT [ IMB ]   2ITT [ RSDB ]
PDB	2ITU [ SRS ]    2ITU [ PdbSum ],   2ITU [ IMB ]   2ITU [ RSDB ]
PDB	2ITV [ SRS ]    2ITV [ PdbSum ],   2ITV [ IMB ]   2ITV [ RSDB ]
PDB	2ITW [ SRS ]    2ITW [ PdbSum ],   2ITW [ IMB ]   2ITW [ RSDB ]
PDB	2ITX [ SRS ]    2ITX [ PdbSum ],   2ITX [ IMB ]   2ITX [ RSDB ]
PDB	2ITY [ SRS ]    2ITY [ PdbSum ],   2ITY [ IMB ]   2ITY [ RSDB ]
PDB	2ITZ [ SRS ]    2ITZ [ PdbSum ],   2ITZ [ IMB ]   2ITZ [ RSDB ]
PDB	2J5E [ SRS ]    2J5E [ PdbSum ],   2J5E [ IMB ]   2J5E [ RSDB ]
PDB	2J5F [ SRS ]    2J5F [ PdbSum ],   2J5F [ IMB ]   2J5F [ RSDB ]
PDB	2J6M [ SRS ]    2J6M [ PdbSum ],   2J6M [ IMB ]   2J6M [ RSDB ]
PDB	2JIT [ SRS ]    2JIT [ PdbSum ],   2JIT [ IMB ]   2JIT [ RSDB ]
PDB	2JIU [ SRS ]    2JIU [ PdbSum ],   2JIU [ IMB ]   2JIU [ RSDB ]
PDB	2JIV [ SRS ]    2JIV [ PdbSum ],   2JIV [ IMB ]   2JIV [ RSDB ]
PDB	2RF9 [ SRS ]    2RF9 [ PdbSum ],   2RF9 [ IMB ]   2RF9 [ RSDB ]
PDB	2RFD [ SRS ]    2RFD [ PdbSum ],   2RFD [ IMB ]   2RFD [ RSDB ]
PDB	2RFE [ SRS ]    2RFE [ PdbSum ],   2RFE [ IMB ]   2RFE [ RSDB ]
PDB	3B2U [ SRS ]    3B2U [ PdbSum ],   3B2U [ IMB ]   3B2U [ RSDB ]
PDB	3B2V [ SRS ]    3B2V [ PdbSum ],   3B2V [ IMB ]   3B2V [ RSDB ]
PDB	3C09 [ SRS ]    3C09 [ PdbSum ],   3C09 [ IMB ]   3C09 [ RSDB ]
HPRD	00579
	Protein Interaction databases
DIP	P00533
IntAct	P00533
	Polymorphism : SNP, mutations, diseases
OMIM	131550;211980    [ map ]
GENECLINICS	131550;211980
SNP	EGFR [dbSNP-NCBI]
SNP	NM_005228 [SNP-NCI]
SNP	NM_201282 [SNP-NCI]
SNP	NM_201283 [SNP-NCI]
SNP	NM_201284 [SNP-NCI]
SNP	EGFR [GeneSNPs - Utah]  EGFR] [HGBASE - SRS]
HAPMAP	EGFR [HAPMAP]
COSMIC	EGFR [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	EGFR
	General knowledge
Family Browser	EGFR [UCSC Family Browser]
SOURCE	NM_005228
SOURCE	NM_201282
SOURCE	NM_201283
SOURCE	NM_201284
SMD	Hs.488293
SAGE	Hs.488293
Enzyme	2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   2.7.10.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	ossification [Amigo]  ossification
GO	double-stranded DNA binding [Amigo]  double-stranded DNA binding
GO	MAP/ERK kinase kinase activity [Amigo]  MAP/ERK kinase kinase activity
GO	transmembrane receptor activity [Amigo]  transmembrane receptor activity
GO	epidermal growth factor receptor activity [Amigo]  epidermal growth factor receptor activity
GO	epidermal growth factor receptor activity [Amigo]  epidermal growth factor receptor activity
GO	ATP binding [Amigo]  ATP binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	endosome [Amigo]  endosome
GO	plasma membrane [Amigo]  plasma membrane
GO	plasma membrane [Amigo]  plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	response to stress [Amigo]  response to stress
GO	cell surface receptor linked signal transduction [Amigo]  cell surface receptor linked signal transduction
GO	epidermal growth factor receptor signaling pathway [Amigo]  epidermal growth factor receptor signaling pathway
GO	activation of phospholipase C activity [Amigo]  activation of phospholipase C activity
GO	integral to membrane [Amigo]  integral to membrane
GO	basolateral plasma membrane [Amigo]  basolateral plasma membrane
GO	cell-cell adhesion [Amigo]  cell-cell adhesion
GO	transferase activity [Amigo]  transferase activity
GO	AP-2 adaptor complex [Amigo]  AP-2 adaptor complex
GO	nitric-oxide synthase regulator activity [Amigo]  nitric-oxide synthase regulator activity
GO	positive regulation of cell migration [Amigo]  positive regulation of cell migration
GO	positive regulation of phosphorylation [Amigo]  positive regulation of phosphorylation
GO	identical protein binding [Amigo]  identical protein binding
GO	calcium-dependent phospholipase A2 activation [Amigo]  calcium-dependent phospholipase A2 activation
GO	positive regulation of MAP kinase activity [Amigo]  positive regulation of MAP kinase activity
GO	positive regulation of nitric oxide biosynthetic process [Amigo]  positive regulation of nitric oxide biosynthetic process
GO	negative regulation of cell cycle [Amigo]  negative regulation of cell cycle
GO	protein heterodimerization activity [Amigo]  protein heterodimerization activity
GO	positive regulation of epithelial cell proliferation [Amigo]  positive regulation of epithelial cell proliferation
GO	regulation of peptidyl-tyrosine phosphorylation [Amigo]  regulation of peptidyl-tyrosine phosphorylation
GO	regulation of nitric-oxide synthase activity [Amigo]  regulation of nitric-oxide synthase activity
GO	actin filament binding [Amigo]  actin filament binding
GO	protein insertion into membrane [Amigo]  protein insertion into membrane
BIOCARTA	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling    [Genes]
BIOCARTA	Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling    [Genes]
BIOCARTA	Agrin in Postsynaptic Differentiation    [Genes]
BIOCARTA	Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy    [Genes]
BIOCARTA	CBL mediated ligand-induced downregulation of EGF receptors    [Genes]
BIOCARTA	The role of FYVE-finger proteins in vesicle transport    [Genes]
BIOCARTA	EGF Signaling Pathway    [Genes]
BIOCARTA	Map Kinase Inactivation of SMRT Corepressor    [Genes]
BIOCARTA	Erk1/Erk2 Mapk Signaling pathway    [Genes]
BIOCARTA	Role of ERBB2 in Signal Transduction and Oncology    [Genes]
BIOCARTA	Keratinocyte Differentiation    [Genes]
BIOCARTA	mCalpain and friends in Cell motility    [Genes]
BIOCARTA	Sprouty regulation of tyrosine kinase signals    [Genes]
BIOCARTA	Telomeres, Telomerase, Cellular Aging, and Immortality    [Genes]
BIOCARTA	Trefoil Factors Initiate Mucosal Healing    [Genes]
KEGG	MAPK signaling pathway
KEGG	Calcium signaling pathway
KEGG	Cytokine-cytokine receptor interaction
KEGG	Dorso-ventral axis formation
KEGG	Focal adhesion
KEGG	Adherens junction
KEGG	Gap junction
KEGG	Regulation of actin cytoskeleton
KEGG	GnRH signaling pathway
KEGG	Epithelial cell signaling in Helicobacter pylori infection
KEGG	Colorectal cancer
PubGene	EGFR
TreeFam	EGFR
CTD	1956 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	EGFR Related clones (RZPD - Berlin)
	PubMed
PubMed	499 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:09:12 2008