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EGFR (epidermal growth factor receptor)

Identity

Other namesERBB
ERBB1
HER1
PIG61
mENA
HGNC (Hugo) EGFR
LocusID (NCBI) 1956
Location 7p11.2
Location_base_pair Starts at 55086725 and ends at 55275031 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494 t1119q23p13ID1540

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors ProstateOverviewID5041 ProstateOverviewID5041 ProstateOverviewID5041 ProstateOverviewID5041 ProstateOverviewID5041
softissuTumID5042 ProstateOverviewID5041 breastID5018 softissuTumID5042 AmeloblastomID5945
MedulloblastomaID5065 rhab5004 EmbryoRhabdomyoID5193 IrisHamartomaID5100

External links

Nomenclature
HGNC (Hugo)EGFR   3236
Cards
Entrez_Gene (NCBI)EGFR  1956  epidermal growth factor receptor
GeneCards (Weizmann)EGFR
Ensembl (Hinxton)ENSG00000146648 [Gene_View]  chr7:55086725-55275031 [Contig_View]  EGFR [Vega]
ICGC DataPortalENSG00000146648
cBioPortalEGFR
AceView (NCBI)EGFR
Genatlas (Paris)EGFR
WikiGenes1956
SOURCE (Princeton)NM_005228 NM_201282 NM_201283 NM_201284
Genomic and cartography
GoldenPath (UCSC)EGFR  -  7p11.2   chr7:55086725-55275031 +  7p11.2   [Description]    (hg19-Feb_2009)
EnsemblEGFR - 7p11.2 [CytoView]
Mapping of homologs : NCBIEGFR [Mapview]
OMIM131550   211980   
Gene and transcription
Genbank (Entrez)AB209442 AF125253 AF277897 AI217671 AK225422
RefSeq transcript (Entrez)NM_005228 NM_201282 NM_201283 NM_201284
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_007726 NT_007819 NW_001839007 NW_004929330
Consensus coding sequences : CCDS (NCBI)EGFR
Cluster EST : UnigeneHs.605083 [ NCBI ]
CGAP (NCI)Hs.605083
Alternative Splicing : Fast-db (Paris)GSHG0027358
Alternative Splicing GalleryENSG00000146648
Gene ExpressionEGFR [ NCBI-GEO ]     EGFR [ SEEK ]   EGFR [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00533 (Uniprot)
NextProtP00533  [Medical]
With graphics : InterProP00533
Splice isoforms : SwissVarP00533 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)EGF_rcpt_L [organisation]   Furin-like_Cys-rich_dom [organisation]   Furin_repeat [organisation]   Growth_fac_rcpt_N_dom [organisation]   Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser-Thr/Tyr_kinase_cat_dom [organisation]   Tyr_kinase_AS [organisation]   Tyr_kinase_cat_dom [organisation]   Tyr_kinase_EGF/ERB/XmrK_rcpt [organisation]  
Related proteins : CluSTrP00533
Domain families : Pfam (Sanger)Furin-like (PF00757)    Pkinase_Tyr (PF07714)    Recep_L_domain (PF01030)   
Domain families : Pfam (NCBI)pfam00757    pfam07714    pfam01030   
Domain families : Smart (EMBL)FU (SM00261)  TyrKc (SM00219)  
DMDM Disease mutations1956
Blocks (Seattle)P00533
PDB (SRS)1DNQ    1DNR    1IVO    1M14    1M17    1MOX    1NQL    1XKK    1YY9    1Z9I    2EB2    2EB3    2EXP    2EXQ    2GS2    2GS6    2GS7    2ITN    2ITO    2ITP    2ITQ    2ITT    2ITU    2ITV    2ITW    2ITX    2ITY    2ITZ    2J5E    2J5F    2J6M    2JIT    2JIU    2JIV    2KS1    2M0B    2M20    2RF9    2RFD    2RFE    2RGP    3B2U    3B2V    3BEL    3BUO    3C09    3G5V    3G5Y    3GOP    3GT8    3IKA    3LZB    3NJP    3OB2    3OP0    3P0Y    3PFV    3POZ    3QWQ    3UG1    3UG2    3VJN    3VJO    3VRP    3VRR    3W2O    3W2P    3W2Q    3W2R    3W2S    3W32    3W33    4G5J    4G5P    4HJO    4I1Z    4I20    4I21    4I22    4I23    4I24    4JQ7    4JQ8    4JR3    4JRV    4KRL    4KRM    4KRO    4KRP    4LI5    4LL0    4LQM    4LRM   
PDB (PDBSum)1DNQ    1DNR    1IVO    1M14    1M17    1MOX    1NQL    1XKK    1YY9    1Z9I    2EB2    2EB3    2EXP    2EXQ    2GS2    2GS6    2GS7    2ITN    2ITO    2ITP    2ITQ    2ITT    2ITU    2ITV    2ITW    2ITX    2ITY    2ITZ    2J5E    2J5F    2J6M    2JIT    2JIU    2JIV    2KS1    2M0B    2M20    2RF9    2RFD    2RFE    2RGP    3B2U    3B2V    3BEL    3BUO    3C09    3G5V    3G5Y    3GOP    3GT8    3IKA    3LZB    3NJP    3OB2    3OP0    3P0Y    3PFV    3POZ    3QWQ    3UG1    3UG2    3VJN    3VJO    3VRP    3VRR    3W2O    3W2P    3W2Q    3W2R    3W2S    3W32    3W33    4G5J    4G5P    4HJO    4I1Z    4I20    4I21    4I22    4I23    4I24    4JQ7    4JQ8    4JR3    4JRV    4KRL    4KRM    4KRO    4KRP    4LI5    4LL0    4LQM    4LRM   
PDB (IMB)1DNQ    1DNR    1IVO    1M14    1M17    1MOX    1NQL    1XKK    1YY9    1Z9I    2EB2    2EB3    2EXP    2EXQ    2GS2    2GS6    2GS7    2ITN    2ITO    2ITP    2ITQ    2ITT    2ITU    2ITV    2ITW    2ITX    2ITY    2ITZ    2J5E    2J5F    2J6M    2JIT    2JIU    2JIV    2KS1    2M0B    2M20    2RF9    2RFD    2RFE    2RGP    3B2U    3B2V    3BEL    3BUO    3C09    3G5V    3G5Y    3GOP    3GT8    3IKA    3LZB    3NJP    3OB2    3OP0    3P0Y    3PFV    3POZ    3QWQ    3UG1    3UG2    3VJN    3VJO    3VRP    3VRR    3W2O    3W2P    3W2Q    3W2R    3W2S    3W32    3W33    4G5J    4G5P    4HJO    4I1Z    4I20    4I21    4I22    4I23    4I24    4JQ7    4JQ8    4JR3    4JRV    4KRL    4KRM    4KRO    4KRP    4LI5    4LL0    4LQM    4LRM   
PDB (RSDB)1DNQ    1DNR    1IVO    1M14    1M17    1MOX    1NQL    1XKK    1YY9    1Z9I    2EB2    2EB3    2EXP    2EXQ    2GS2    2GS6    2GS7    2ITN    2ITO    2ITP    2ITQ    2ITT    2ITU    2ITV    2ITW    2ITX    2ITY    2ITZ    2J5E    2J5F    2J6M    2JIT    2JIU    2JIV    2KS1    2M0B    2M20    2RF9    2RFD    2RFE    2RGP    3B2U    3B2V    3BEL    3BUO    3C09    3G5V    3G5Y    3GOP    3GT8    3IKA    3LZB    3NJP    3OB2    3OP0    3P0Y    3PFV    3POZ    3QWQ    3UG1    3UG2    3VJN    3VJO    3VRP    3VRR    3W2O    3W2P    3W2Q    3W2R    3W2S    3W32    3W33    4G5J    4G5P    4HJO    4I1Z    4I20    4I21    4I22    4I23    4I24    4JQ7    4JQ8    4JR3    4JRV    4KRL    4KRM    4KRO    4KRP    4LI5    4LL0    4LQM    4LRM   
Human Protein AtlasENSG00000146648 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP00533
HPRD00579
IPIIPI00018274   IPI00221346   IPI00221347   IPI00221348   IPI00930194   IPI00930693   IPI01026443   IPI00915452   IPI01013089   IPI01011440   IPI00930192   IPI00930294   IPI00956452   IPI00943104   IPI00924546   IPI00926683   
Protein Interaction databases
DIP (DOE-UCLA)P00533
IntAct (EBI)P00533
FunCoupENSG00000146648
BioGRIDEGFR
InParanoidP00533
Interologous Interaction database P00533
IntegromeDBEGFR
STRING (EMBL)EGFR
Ontologies - Pathways
Ontology : AmiGOGolgi membrane  MAPK cascade  activation of MAPKK activity  ossification  liver development  embryonic placenta development  positive regulation of protein phosphorylation  hair follicle development  glycoprotein binding  chromatin binding  double-stranded DNA binding  MAP kinase kinase kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  transmembrane signaling receptor activity  epidermal growth factor-activated receptor activity  epidermal growth factor-activated receptor activity  integrin binding  protein binding  ATP binding  extracellular space  nucleus  cytoplasm  endosome  endoplasmic reticulum membrane  plasma membrane  plasma membrane  polysaccharide metabolic process  translation  response to stress  response to osmotic stress  response to oxidative stress  signal transduction  signal transduction  cell surface receptor signaling pathway  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  activation of phospholipase C activity  axon guidance  salivary gland morphogenesis  learning or memory  circadian rhythm  cell proliferation  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  cell surface  endosome membrane  magnesium ion homeostasis  membrane  integral component of membrane  diterpenoid metabolic process  basolateral plasma membrane  apical plasma membrane  single organismal cell-cell adhesion  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  alkanesulfonate metabolic process  enzyme binding  protein kinase binding  protein phosphatase binding  cerebral cortex cell migration  AP-2 adaptor complex  nitric-oxide synthase regulator activity  lung development  positive regulation of cell migration  positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle  nuclear membrane  positive regulation of superoxide anion generation  response to cobalamin  response to hydroxyisoflavone  positive regulation of catenin import into nucleus  cellular response to drug  Fc-epsilon receptor signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  negative regulation of protein catabolic process  positive regulation of phosphorylation  ovulation cycle  hydrogen peroxide metabolic process  identical protein binding  activation of phospholipase A2 activity by calcium-mediated signaling  negative regulation of apoptotic process  receptor complex  positive regulation of MAP kinase activity  tongue development  innate immune response  membrane raft  positive regulation of nitric oxide biosynthetic process  positive regulation of DNA repair  positive regulation of DNA replication  positive regulation of vasoconstriction  positive regulation of vasodilation  negative regulation of mitotic cell cycle  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  astrocyte activation  positive regulation of fibroblast proliferation  epidermal growth factor binding  perinuclear region of cytoplasm  digestive tract morphogenesis  positive regulation of smooth muscle cell proliferation  positive regulation of epithelial cell proliferation  positive regulation of inflammatory response  regulation of peptidyl-tyrosine phosphorylation  regulation of nitric-oxide synthase activity  actin filament binding  protein insertion into membrane  response to calcium ion  positive regulation of protein kinase B signaling  positive regulation of synaptic transmission, glutamatergic  morphogenesis of an epithelial fold  response to UV-A  positive regulation of ERK1 and ERK2 cascade  Shc-EGFR complex  cellular response to mechanical stimulus  cellular response to epidermal growth factor stimulus  cellular response to estradiol stimulus  cellular response to dexamethasone stimulus  
Ontology : EGO-EBIGolgi membrane  MAPK cascade  activation of MAPKK activity  ossification  liver development  embryonic placenta development  positive regulation of protein phosphorylation  hair follicle development  glycoprotein binding  chromatin binding  double-stranded DNA binding  MAP kinase kinase kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  receptor signaling protein tyrosine kinase activity  transmembrane signaling receptor activity  epidermal growth factor-activated receptor activity  epidermal growth factor-activated receptor activity  integrin binding  protein binding  ATP binding  extracellular space  nucleus  cytoplasm  endosome  endoplasmic reticulum membrane  plasma membrane  plasma membrane  polysaccharide metabolic process  translation  response to stress  response to osmotic stress  response to oxidative stress  signal transduction  signal transduction  cell surface receptor signaling pathway  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  activation of phospholipase C activity  axon guidance  salivary gland morphogenesis  learning or memory  circadian rhythm  cell proliferation  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  cell surface  endosome membrane  magnesium ion homeostasis  membrane  integral component of membrane  diterpenoid metabolic process  basolateral plasma membrane  apical plasma membrane  single organismal cell-cell adhesion  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  alkanesulfonate metabolic process  enzyme binding  protein kinase binding  protein phosphatase binding  cerebral cortex cell migration  AP-2 adaptor complex  nitric-oxide synthase regulator activity  lung development  positive regulation of cell migration  positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle  nuclear membrane  positive regulation of superoxide anion generation  response to cobalamin  response to hydroxyisoflavone  positive regulation of catenin import into nucleus  cellular response to drug  Fc-epsilon receptor signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  negative regulation of protein catabolic process  positive regulation of phosphorylation  ovulation cycle  hydrogen peroxide metabolic process  identical protein binding  activation of phospholipase A2 activity by calcium-mediated signaling  negative regulation of apoptotic process  receptor complex  positive regulation of MAP kinase activity  tongue development  innate immune response  membrane raft  positive regulation of nitric oxide biosynthetic process  positive regulation of DNA repair  positive regulation of DNA replication  positive regulation of vasoconstriction  positive regulation of vasodilation  negative regulation of mitotic cell cycle  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  astrocyte activation  positive regulation of fibroblast proliferation  epidermal growth factor binding  perinuclear region of cytoplasm  digestive tract morphogenesis  positive regulation of smooth muscle cell proliferation  positive regulation of epithelial cell proliferation  positive regulation of inflammatory response  regulation of peptidyl-tyrosine phosphorylation  regulation of nitric-oxide synthase activity  actin filament binding  protein insertion into membrane  response to calcium ion  positive regulation of protein kinase B signaling  positive regulation of synaptic transmission, glutamatergic  morphogenesis of an epithelial fold  response to UV-A  positive regulation of ERK1 and ERK2 cascade  Shc-EGFR complex  cellular response to mechanical stimulus  cellular response to epidermal growth factor stimulus  cellular response to estradiol stimulus  cellular response to dexamethasone stimulus  
Pathways : BIOCARTATrefoil Factors Initiate Mucosal Healing [Genes]    Agrin in Postsynaptic Differentiation [Genes]    The role of FYVE-finger proteins in vesicle transport [Genes]    mCalpain and friends in Cell motility [Genes]    Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling [Genes]    CBL mediated ligand-induced downregulation of EGF receptors [Genes]    Keratinocyte Differentiation [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    Sprouty regulation of tyrosine kinase signals [Genes]    Telomeres, Telomerase, Cellular Aging, and Immortality [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]    EGF Signaling Pathway [Genes]    Map Kinase Inactivation of SMRT Corepressor [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Calcium signaling pathway    Cytokine-cytokine receptor interaction    HIF-1 signaling pathway    FoxO signaling pathway    Endocytosis    PI3K-Akt signaling pathway    Dorso-ventral axis formation    Focal adhesion    Adherens junction    Gap junction    Regulation of actin cytoskeleton    GnRH signaling pathway    Estrogen signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Hepatitis C    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Pancreatic cancer    Endometrial cancer    Glioma    Prostate cancer    Melanoma    Bladder cancer    Non-small cell lung cancer   
Protein Interaction DatabaseEGFR
Wikipedia pathwaysEGFR
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EGFR
snp3D : Map Gene to Disease1956
SNP (GeneSNP Utah)EGFR
SNP : HGBaseEGFR
Genetic variants : HAPMAPEGFR
Exome VariantEGFR
1000_GenomesEGFR 
ICGC programENSG00000146648 
Cancer Gene: CensusEGFR 
Somatic Mutations in Cancer : COSMICEGFR 
CONAN: Copy Number AnalysisEGFR 
Mutations and Diseases : HGMDEGFR
Genomic VariantsEGFR  EGFR [DGVbeta]
dbVarEGFR
ClinVarEGFR
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM131550    211980   
MedgenEGFR
GENETestsEGFR
Disease Genetic AssociationEGFR
Huge Navigator EGFR [HugePedia]  EGFR [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneEGFR
Homology/Alignments : Family Browser (UCSC)EGFR
Phylogenetic Trees/Animal Genes : TreeFamEGFR
Chemical/Protein Interactions : CTD1956
Chemical/Pharm GKB GenePA7360
Drug Sensitivity EGFR
Clinical trialEGFR
Cancer Resource (Charite)ENSG00000146648
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineEGFR
iHOPEGFR
OncoSearchEGFR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:30:38 CEST 2014

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