Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EGR2 (early growth response 2)

Identity

Alias (NCBI)AT591
CHN1
CMT1D
CMT4E
KROX20
HGNC (Hugo) EGR2
HGNC Alias nameKrox-20 homolog, Drosophila
HGNC Previous nameKROX20
HGNC Previous nameearly growth response 2 (Krox-20 homolog, Drosophila)
LocusID (NCBI) 1959
Atlas_Id 40419
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 62811996 and ends at 62816366 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EGR2   3239
LRG (Locus Reference Genomic)LRG_239
Cards
Entrez_Gene (NCBI)EGR2    early growth response 2
AliasesAT591; CHN1; CMT1D; CMT4E; 
KROX20
GeneCards (Weizmann)EGR2
Ensembl hg19 (Hinxton)ENSG00000122877 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122877 [Gene_View]  ENSG00000122877 [Sequence]  chr10:62811996-62816366 [Contig_View]  EGR2 [Vega]
ICGC DataPortalENSG00000122877
TCGA cBioPortalEGR2
AceView (NCBI)EGR2
Genatlas (Paris)EGR2
SOURCE (Princeton)EGR2
Genetics Home Reference (NIH)EGR2
Genomic and cartography
GoldenPath hg38 (UCSC)EGR2  -     chr10:62811996-62816366 -  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EGR2  -     10q21.3   [Description]    (hg19-Feb_2009)
GoldenPathEGR2 - 10q21.3 [CytoView hg19]  EGR2 - 10q21.3 [CytoView hg38]
ImmunoBaseENSG00000122877
Genome Data Viewer NCBIEGR2 [Mapview hg19]  
OMIM129010   145900   605253   607678   
Gene and transcription
Genbank (Entrez)AF139463 AK091399 AK296830 AK312813 BC035625
RefSeq transcript (Entrez)NM_000399 NM_001136177 NM_001136178 NM_001136179 NM_001321037
Consensus coding sequences : CCDS (NCBI)EGR2
Gene ExpressionEGR2 [ NCBI-GEO ]   EGR2 [ EBI - ARRAY_EXPRESS ]   EGR2 [ SEEK ]   EGR2 [ MEM ]
Gene Expression Viewer (FireBrowse)EGR2 [ Firebrowse - Broad ]
GenevisibleExpression of EGR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1959
GTEX Portal (Tissue expression)EGR2
Human Protein AtlasENSG00000122877-EGR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11161   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11161  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11161
PhosPhoSitePlusP11161
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)EGR_N    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)DUF3446 (PF11928)    zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam11928    pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)EGR2
SuperfamilyP11161
AlphaFold pdb e-kbP11161   
Human Protein Atlas [tissue]ENSG00000122877-EGR2 [tissue]
HPRD00551
Protein Interaction databases
DIP (DOE-UCLA)P11161
IntAct (EBI)P11161
BioGRIDEGR2
STRING (EMBL)EGR2
ZODIACEGR2
Ontologies - Pathways
QuickGOP11161
Ontology : AmiGOchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription by RNA polymerase II  protein export from nucleus  nervous system development  brain development  peripheral nervous system development  learning or memory  rhythmic behavior  motor neuron axon guidance  gene expression  Schwann cell differentiation  positive regulation of Schwann cell differentiation  protein sumoylation  protein sumoylation  facial nerve structural organization  rhombomere 3 structural organization  rhombomere 3 formation  rhombomere 5 structural organization  rhombomere 5 formation  regulation of ossification  ubiquitin protein ligase binding  positive regulation of myelination  response to insulin  brain segmentation  skeletal muscle cell differentiation  myelination  intracellular membrane-bounded organelle  sequence-specific DNA binding  fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  metal ion binding  regulation of neuronal synaptic plasticity  RNA polymerase II-specific DNA-binding transcription factor binding  SUMO ligase activity  cellular response to organic substance  HMG box domain binding  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription by RNA polymerase II  protein export from nucleus  nervous system development  brain development  peripheral nervous system development  learning or memory  rhythmic behavior  motor neuron axon guidance  gene expression  Schwann cell differentiation  positive regulation of Schwann cell differentiation  protein sumoylation  protein sumoylation  facial nerve structural organization  rhombomere 3 structural organization  rhombomere 3 formation  rhombomere 5 structural organization  rhombomere 5 formation  regulation of ossification  ubiquitin protein ligase binding  positive regulation of myelination  response to insulin  brain segmentation  skeletal muscle cell differentiation  myelination  intracellular membrane-bounded organelle  sequence-specific DNA binding  fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  metal ion binding  regulation of neuronal synaptic plasticity  RNA polymerase II-specific DNA-binding transcription factor binding  SUMO ligase activity  cellular response to organic substance  HMG box domain binding  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTANeuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]   
Pathways : KEGGHepatitis B    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkEGR2
Atlas of Cancer Signalling NetworkEGR2
Wikipedia pathwaysEGR2
Orthology - Evolution
OrthoDB1959
GeneTree (enSembl)ENSG00000122877
Phylogenetic Trees/Animal Genes : TreeFamEGR2
Homologs : HomoloGeneEGR2
Homology/Alignments : Family Browser (UCSC)EGR2
Gene fusions - Rearrangements
Fusion : QuiverEGR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEGR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EGR2
dbVarEGR2
ClinVarEGR2
MonarchEGR2
1000_GenomesEGR2 
Exome Variant ServerEGR2
GNOMAD BrowserENSG00000122877
Varsome BrowserEGR2
ACMGEGR2 variants
VarityP11161
Genomic Variants (DGV)EGR2 [DGVbeta]
DECIPHEREGR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEGR2 
Mutations
ICGC Data PortalEGR2 
TCGA Data PortalEGR2 
Broad Tumor PortalEGR2
OASIS PortalEGR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEGR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEGR2
Mutations and Diseases : HGMDEGR2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEGR2
DgiDB (Drug Gene Interaction Database)EGR2
DoCM (Curated mutations)EGR2
CIViC (Clinical Interpretations of Variants in Cancer)EGR2
Cancer3DEGR2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM129010    145900    605253    607678   
Orphanet10852    14795    14524   
DisGeNETEGR2
MedgenEGR2
Genetic Testing Registry EGR2
NextProtP11161 [Medical]
GENETestsEGR2
Target ValidationEGR2
Huge Navigator EGR2 [HugePedia]
ClinGenEGR2 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeEGR2
Protein Interactions : CTDEGR2
Pharm GKB GenePA27674
PharosP11161
Clinical trialEGR2
Miscellaneous
canSAR (ICR)EGR2
HarmonizomeEGR2
DataMed IndexEGR2
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEGR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:07:48 CEST 2021

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