Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

EGR2 (early growth response 2)

Identity

Alias_namesDrosophila
KROX20
Other aliasAT591
CMT1D
CMT4E
HGNC (Hugo) EGR2
LocusID (NCBI) 1959
Atlas_Id 40419
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 62811996 and ends at 62816380 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EGR2   3239
LRG (Locus Reference Genomic)LRG_239
Cards
Entrez_Gene (NCBI)EGR2  1959  early growth response 2
AliasesAT591; CMT1D; CMT4E; KROX20
GeneCards (Weizmann)EGR2
Ensembl hg19 (Hinxton)ENSG00000122877 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122877 [Gene_View]  chr10:62811996-62816380 [Contig_View]  EGR2 [Vega]
ICGC DataPortalENSG00000122877
TCGA cBioPortalEGR2
AceView (NCBI)EGR2
Genatlas (Paris)EGR2
WikiGenes1959
SOURCE (Princeton)EGR2
Genetics Home Reference (NIH)EGR2
Genomic and cartography
GoldenPath hg38 (UCSC)EGR2  -     chr10:62811996-62816380 -  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EGR2  -     10q21.3   [Description]    (hg19-Feb_2009)
EnsemblEGR2 - 10q21.3 [CytoView hg19]  EGR2 - 10q21.3 [CytoView hg38]
Mapping of homologs : NCBIEGR2 [Mapview hg19]  EGR2 [Mapview hg38]
OMIM129010   145900   605253   607678   
Gene and transcription
Genbank (Entrez)AF139463 AK091399 AK296830 AK312813 BC035625
RefSeq transcript (Entrez)NM_000399 NM_001136177 NM_001136178 NM_001136179 NM_001321037
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EGR2
Cluster EST : UnigeneHs.1395 [ NCBI ]
CGAP (NCI)Hs.1395
Alternative Splicing GalleryENSG00000122877
Gene ExpressionEGR2 [ NCBI-GEO ]   EGR2 [ EBI - ARRAY_EXPRESS ]   EGR2 [ SEEK ]   EGR2 [ MEM ]
Gene Expression Viewer (FireBrowse)EGR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1959
GTEX Portal (Tissue expression)EGR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11161   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11161  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11161
Splice isoforms : SwissVarP11161
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusP11161
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)DUF3446    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)DUF3446 (PF11928)    zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam11928    pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)EGR2
DMDM Disease mutations1959
Blocks (Seattle)EGR2
SuperfamilyP11161
Human Protein AtlasENSG00000122877
Peptide AtlasP11161
HPRD00551
IPIIPI00305368   IPI00797785   IPI00909293   
Protein Interaction databases
DIP (DOE-UCLA)P11161
IntAct (EBI)P11161
FunCoupENSG00000122877
BioGRIDEGR2
STRING (EMBL)EGR2
ZODIACEGR2
Ontologies - Pathways
QuickGOP11161
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II activating transcription factor binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  transcription from RNA polymerase II promoter  protein export from nucleus  brain development  peripheral nervous system development  learning or memory  rhythmic behavior  motor neuron axon guidance  Schwann cell differentiation  ligase activity  protein sumoylation  facial nerve structural organization  rhombomere 3 formation  rhombomere 5 formation  regulation of ossification  ubiquitin protein ligase binding  response to insulin  brain segmentation  skeletal muscle cell differentiation  myelination  intracellular membrane-bounded organelle  transcription regulatory region DNA binding  fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  regulation of neuronal synaptic plasticity  cellular response to organic substance  HMG box domain binding  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II activating transcription factor binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  transcription from RNA polymerase II promoter  protein export from nucleus  brain development  peripheral nervous system development  learning or memory  rhythmic behavior  motor neuron axon guidance  Schwann cell differentiation  ligase activity  protein sumoylation  facial nerve structural organization  rhombomere 3 formation  rhombomere 5 formation  regulation of ossification  ubiquitin protein ligase binding  response to insulin  brain segmentation  skeletal muscle cell differentiation  myelination  intracellular membrane-bounded organelle  transcription regulatory region DNA binding  fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  regulation of neuronal synaptic plasticity  cellular response to organic substance  HMG box domain binding  
Pathways : BIOCARTANeuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]   
Pathways : KEGGHepatitis B    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkEGR2
Atlas of Cancer Signalling NetworkEGR2
Wikipedia pathwaysEGR2
Orthology - Evolution
OrthoDB1959
GeneTree (enSembl)ENSG00000122877
Phylogenetic Trees/Animal Genes : TreeFamEGR2
HOVERGENP11161
HOGENOMP11161
Homologs : HomoloGeneEGR2
Homology/Alignments : Family Browser (UCSC)EGR2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEGR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EGR2
dbVarEGR2
ClinVarEGR2
1000_GenomesEGR2 
Exome Variant ServerEGR2
ExAC (Exome Aggregation Consortium)EGR2 (select the gene name)
Genetic variants : HAPMAP1959
Genomic Variants (DGV)EGR2 [DGVbeta]
DECIPHEREGR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEGR2 
Mutations
ICGC Data PortalEGR2 
TCGA Data PortalEGR2 
Broad Tumor PortalEGR2
OASIS PortalEGR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEGR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEGR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EGR2
DgiDB (Drug Gene Interaction Database)EGR2
DoCM (Curated mutations)EGR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EGR2 (select a term)
intoGenEGR2
Cancer3DEGR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM129010    145900    605253    607678   
Orphanet10852    14795    14524   
MedgenEGR2
Genetic Testing Registry EGR2
NextProtP11161 [Medical]
TSGene1959
GENETestsEGR2
Target ValidationEGR2
Huge Navigator EGR2 [HugePedia]
snp3D : Map Gene to Disease1959
BioCentury BCIQEGR2
ClinGenEGR2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1959
Chemical/Pharm GKB GenePA27674
Clinical trialEGR2
Miscellaneous
canSAR (ICR)EGR2 (select the gene name)
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEGR2
EVEXEGR2
GoPubMedEGR2
iHOPEGR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:06:35 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.