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EIF2A (eukaryotic translation initiation factor 2A)

Identity

Alias_nameseukaryotic translation initiation factor 2A
Alias_symbol (synonym)EIF-2A
Other aliasCDA02
MST089
MSTP004
MSTP089
HGNC (Hugo) EIF2A
LocusID (NCBI) 83939
Atlas_Id 52079
Location 3q25.1  [Link to chromosome band 3q25]
Location_base_pair Starts at 150546678 and ends at 150586016 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALCAM (3q13.11) / EIF2A (3q25.1)EIF2A (3q25.1) / ANKUB1 (3q25.1)EIF2A (3q25.1) / MED12L (3q25.1)
RNF139 (8q24.13) / EIF2A (3q25.1)ALCAM 3q13.11 / EIF2A 3q25.1EIF2A 3q25.1 / ANKUB1 3q25.1
RNF139 8q24.13 / EIF2A 3q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EIF2A   3254
Cards
Entrez_Gene (NCBI)EIF2A  83939  eukaryotic translation initiation factor 2A
AliasesCDA02; EIF-2A; MST089; MSTP004; 
MSTP089
GeneCards (Weizmann)EIF2A
Ensembl hg19 (Hinxton)ENSG00000144895 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144895 [Gene_View]  chr3:150546678-150586016 [Contig_View]  EIF2A [Vega]
ICGC DataPortalENSG00000144895
TCGA cBioPortalEIF2A
AceView (NCBI)EIF2A
Genatlas (Paris)EIF2A
WikiGenes83939
SOURCE (Princeton)EIF2A
Genetics Home Reference (NIH)EIF2A
Genomic and cartography
GoldenPath hg38 (UCSC)EIF2A  -     chr3:150546678-150586016 +  3q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EIF2A  -     3q25.1   [Description]    (hg19-Feb_2009)
EnsemblEIF2A - 3q25.1 [CytoView hg19]  EIF2A - 3q25.1 [CytoView hg38]
Mapping of homologs : NCBIEIF2A [Mapview hg19]  EIF2A [Mapview hg38]
OMIM609234   
Gene and transcription
Genbank (Entrez)AF109358 AF172818 AF212241 AF497978 AI560242
RefSeq transcript (Entrez)NM_001319043 NM_001319044 NM_001319045 NM_001319046 NM_032025
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EIF2A
Cluster EST : UnigeneHs.655782 [ NCBI ]
CGAP (NCI)Hs.655782
Alternative Splicing GalleryENSG00000144895
Gene ExpressionEIF2A [ NCBI-GEO ]   EIF2A [ EBI - ARRAY_EXPRESS ]   EIF2A [ SEEK ]   EIF2A [ MEM ]
Gene Expression Viewer (FireBrowse)EIF2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83939
GTEX Portal (Tissue expression)EIF2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BY44   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BY44  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BY44
Splice isoforms : SwissVarQ9BY44
PhosPhoSitePlusQ9BY44
Domains : Interpro (EBI)TIF2A    TIF_beta_prop-like    WD40/YVTN_repeat-like_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)eIF2A (PF08662)   
Domain families : Pfam (NCBI)pfam08662   
Conserved Domain (NCBI)EIF2A
DMDM Disease mutations83939
Blocks (Seattle)EIF2A
SuperfamilyQ9BY44
Human Protein AtlasENSG00000144895
Peptide AtlasQ9BY44
HPRD11739
IPIIPI00939283   IPI00012462   IPI00945725   IPI00845305   IPI00982376   IPI00946890   IPI00946070   IPI00945881   IPI00945739   IPI00797021   IPI00945560   
Protein Interaction databases
DIP (DOE-UCLA)Q9BY44
IntAct (EBI)Q9BY44
FunCoupENSG00000144895
BioGRIDEIF2A
STRING (EMBL)EIF2A
ZODIACEIF2A
Ontologies - Pathways
QuickGOQ9BY44
Ontology : AmiGOtRNA binding  mRNA binding  translation initiation factor activity  protein binding  extracellular space  cytoplasm  eukaryotic translation initiation factor 2 complex  translational initiation  regulation of translation  protein phosphorylation  positive regulation of signal transduction  cytosolic small ribosomal subunit  SREBP signaling pathway  ribosome assembly  ribosome binding  cadherin binding  blood microparticle  response to amino acid starvation  
Ontology : EGO-EBItRNA binding  mRNA binding  translation initiation factor activity  protein binding  extracellular space  cytoplasm  eukaryotic translation initiation factor 2 complex  translational initiation  regulation of translation  protein phosphorylation  positive regulation of signal transduction  cytosolic small ribosomal subunit  SREBP signaling pathway  ribosome assembly  ribosome binding  cadherin binding  blood microparticle  response to amino acid starvation  
NDEx NetworkEIF2A
Atlas of Cancer Signalling NetworkEIF2A
Wikipedia pathwaysEIF2A
Orthology - Evolution
OrthoDB83939
GeneTree (enSembl)ENSG00000144895
Phylogenetic Trees/Animal Genes : TreeFamEIF2A
HOVERGENQ9BY44
HOGENOMQ9BY44
Homologs : HomoloGeneEIF2A
Homology/Alignments : Family Browser (UCSC)EIF2A
Gene fusions - Rearrangements
Fusion : MitelmanALCAM/EIF2A [3q13.11/3q25.1]  [t(3;3)(q13;q25)]  
Fusion : MitelmanEIF2A/ANKUB1 [3q25.1/3q25.1]  [t(3;3)(q25;q25)]  
Fusion : MitelmanRNF139/EIF2A [8q24.13/3q25.1]  [t(3;8)(q25;q24)]  
Fusion: TCGAALCAM 3q13.11 EIF2A 3q25.1 BRCA
Fusion: TCGAEIF2A 3q25.1 ANKUB1 3q25.1 OV
Fusion: TCGARNF139 8q24.13 EIF2A 3q25.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEIF2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EIF2A
dbVarEIF2A
ClinVarEIF2A
1000_GenomesEIF2A 
Exome Variant ServerEIF2A
ExAC (Exome Aggregation Consortium)EIF2A (select the gene name)
Genetic variants : HAPMAP83939
Genomic Variants (DGV)EIF2A [DGVbeta]
DECIPHEREIF2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEIF2A 
Mutations
ICGC Data PortalEIF2A 
TCGA Data PortalEIF2A 
Broad Tumor PortalEIF2A
OASIS PortalEIF2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEIF2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEIF2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EIF2A
DgiDB (Drug Gene Interaction Database)EIF2A
DoCM (Curated mutations)EIF2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EIF2A (select a term)
intoGenEIF2A
Cancer3DEIF2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609234   
Orphanet
MedgenEIF2A
Genetic Testing Registry EIF2A
NextProtQ9BY44 [Medical]
TSGene83939
GENETestsEIF2A
Huge Navigator EIF2A [HugePedia]
snp3D : Map Gene to Disease83939
BioCentury BCIQEIF2A
ClinGenEIF2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83939
Chemical/Pharm GKB GenePA143485453
Clinical trialEIF2A
Miscellaneous
canSAR (ICR)EIF2A (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEIF2A
EVEXEIF2A
GoPubMedEIF2A
iHOPEIF2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:14:25 CEST 2017

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