EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1)

2016-10-01  

Identity

HGNC
LOCATION
7p22.1
LOCUSID
ALIAS
HCR,HRI,LEMSPAD,hHRI
FUSION GENES

Other Information

Locus ID:

NCBI: 27102
MIM: 613635
HGNC: 24921
Ensembl: ENSG00000086232

Variants:

dbSNP: 27102
ClinVar: 27102
TCGA: ENSG00000086232
COSMIC: EIF2AK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086232ENST00000199389Q9BQI3
ENSG00000086232ENST00000199389A0A024QZU1
ENSG00000086232ENST00000422786H7C033
ENSG00000086232ENST00000431744F8WCM0
ENSG00000086232ENST00000446699C9J7U7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
233926802013Blocking the eIF2α kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory.29
300262272018Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.14
127672372003Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI.13
200714492010Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.11
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
321327072020Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.7
275574992016Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons.5
238747492013The host-encoded Heme Regulated Inhibitor (HRI) facilitates virulence-associated activities of bacterial pathogens.4
315546362019Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies.4
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3

Citation

Dessen P

EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56582/eif2ak1